Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases are excluded, with the following exceptions:\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n** No neurosurgical resection or brain biopsy within  days prior to cycle , day \r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and radiographic screening for the current study\r\n** No stereotactic radiation or whole-brain radiation within  days prior to cycle , day \r\n** Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids
Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases, with the following exceptions: \r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of clinical stability upon the completion of CNS directed therapy and no evidence of interim progression between the completion of CNS directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation within  days prior to randomization\r\n** Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids
Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases are excluded, with the following exceptions:\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n** No neurosurgical resection or brain biopsy within  days prior to cycle , day \r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS directed therapy and no evidence of interim progression between the completion of CNS directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation within  days prior to cycle , day \r\n** Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids
Patients with central nervous system (CNS) metastases are excluded, with the following exceptions:\r\n* Patients with asymptomatic untreated CNS metastases may be enrolled, provided all eligibility criteria are met, as well as the following:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted.\r\n** No neurosurgical resection or brain biopsy within  days prior to randomization\r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all eligibility criteria are met, as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation within  days prior to randomization \r\n** Screening CNS radiographic study >=  days from completion of radiotherapy and >=  days from discontinuation of corticosteroids
Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases are excluded, with the following exceptions:\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n** No neurosurgical resection or brain biopsy within  days prior to cycle , day \r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS directed therapy and no evidence of interim progression between the completion of CNS directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation within  days prior to cycle , day \r\n** Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids
Participants with a history of treated central nervous system (CNS) metastases are eligible, provided they meet all of the following criteria:\r\n* Disease outside the CNS is present\r\n* No evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study\r\n* No history of intracranial hemorrhage or spinal cord hemorrhage\r\n* Not requiring anti-convulsants for symptomatic control\r\n* Minimum of  weeks between completion of CNS radiotherapy and cycle  day  and recovery from significant (grade >= ) acute toxicity with no ongoing requirement for corticosteroid
Patients with a history of treated central nervous system (CNS) metastases are eligible, provided they meet all of the following criteria: disease outside the CNS is present; no clinical evidence of progression since completion of CNS-directed therapy; minimum of  weeks between completion of radiotherapy and cycle  day  and recovery from significant (grade ? ) acute toxicity with no ongoing requirement for >  mg of prednisone per day or an equivalent dose of other corticosteroid; NOTE: patient can receive a stable dose of corticosteroids before and during the study as long as these were started at least  weeks prior to treatment
Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases are excluded, with the following exceptions:\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** There are no more than  lesions, =<  cm in size each\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n** No neurosurgical resection or brain biopsy within  days prior to cycle , day \r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS directed therapy and no evidence of interim progression between the completion of CNS directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation within  days prior to cycle , day \r\n** Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids
Known primary central nervous system (CNS) malignancy or symptomatic CNS metastases.\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS.\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm).\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage.\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted.\r\n** No neurosurgical resection or brain biopsy within  days prior to start of study treatment.\r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study.\r\n** No stereotactic radiation or whole-brain radiation within  days prior to start of study treatment.\r\n** Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids.
Known untreated or active central nervous system (CNS) metastases (progressing or requiring anticonvulsants or corticosteroids for symptomatic control); patients with a history of treated CNS metastases are eligible, provided that they meet all of the following criteria:\r\n* Presence of measurable disease outside the CNS\r\n* No radiographic evidence of worsening upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study\r\n* No history of intracranial hemorrhage or spinal cord hemorrhage\r\n* No ongoing requirement for dexamethasone as therapy for CNS disease (anticonvulsants at a stable dose are allowed)\r\n* Absence of leptomeningeal disease
Active or untreated central nervous system (CNS) metastases as determined by computed tomography (CT) or magnetic resonance imaging (MRI) evaluation during screening and prior radiographic assessments; subjects with treated asymptomatic CNS metastases are eligible, provided they meet all of the following criteria:\r\n* Evaluable or measurable disease outside the CNS\r\n* No metastases to midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n* No history of intracranial or spinal cord hemorrhage\r\n* No evidence of significant vasogenic edema\r\n* o ongoing requirement for dexamethasone as therapy for CNS disease; anticonvulsants at a stable dose allowed\r\n* No stereotactic radiation, whole-brain radiation within  weeks prior to cycle  day \r\n* Subjects with CNS metastases treated by neurosurgical resection or brain biopsy within  months prior to cycle  day  will be excluded\r\n* Radiographic demonstration of interim stability (i.e., no progression) between the completion of CNS-directed therapy and the screening radiographic study\r\n* Screening CNS radiographic study >=  weeks since completion of radiotherapy or surgical resection and >=  weeks since discontinuation of corticosteroids
Known primary central nervous system (CNS) malignancy or symptomatic CNS metastases\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n** No neurosurgical resection or brain biopsy =<  days prior to cycle , day \r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation =<  days prior to cycle , day \r\n** Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids
Known primary central nervous system (CNS) malignancy or symptomatic CNS metastases\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\nNo neurosurgical resection or brain biopsy within  days prior to cycle , day \r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation within  days prior to cycle , day \r\n** Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids
Known primary central nervous system (CNS) malignancy or symptomatic CNS metastases\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n** No neurosurgical resection or brain biopsy within  days prior to cycle , day \r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study\r\n** Screening CNS radiographic study ?  weeks from completion of radiotherapy and ?  weeks from discontinuation of corticosteroids
Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases are excluded, with the following exceptions:\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n** No neurosurgical resection or brain biopsy within  days before initiation of study treatment\r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS directed therapy and no evidence of interim progression between the completion of CNS directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation within  days before initiation of study treatment\r\n** Screening CNS radiographic study ?  weeks from completion of radiotherapy and ?  weeks from discontinuation of corticosteroids
Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases are excluded, with the following exceptions:\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n** No neurosurgical resection or brain biopsy within  days prior to randomization\r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS directed therapy and no evidence of interim progression between the completion of CNS directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation within  weeks prior to randomization.\r\n** Screening CNS radiographic study  weeks from completion of radiotherapy and  weeks from discontinuation of corticosteroids
Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases are excluded, with the following exceptions\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n** No neurosurgical resection or brain biopsy =<  days prior to registration\r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation =<  days prior to registration\r\n** Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids
Known primary central nervous system (CNS) malignancy or symptomatic CNS metastases\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n** No neurosurgical resection or brain biopsy within  days prior to cycle , day \r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation within  days prior to cycle , day \r\n* Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids
Participants who have a primary central nervous system (CNS) malignancy, or untreated/active CNS metastases (progressing or requiring anticonvulsants or corticosteroids for symptomatic control); individuals with a history of treated CNS metastases are eligible, provided they meet all of the following criteria:\r\n* Evaluable or measurable disease outside the CNS\r\n* Radiographic demonstration of stability upon the completion of CNS directed therapy and no evidence of interim progression (for at least  weeks prior to the first dose of study drug) between the completion of CNS-directed therapy and the screening radiographic procedure\r\n* The screening CNS radiographic procedure is >=  weeks since completion of radiotherapy and >=  weeks since the discontinuation of corticosteroids and anticonvulsants\r\n* Note: These exceptions do not include carcinomatous meningitis which is excluded regardless of clinical stability
Patients with asymptomatic untreated CNS disease may be enrolled after consultation, provided all of the following criteria are met:\r\n* Evaluable or measurable disease outside the CNS\r\n* No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n* No history of intracranial hemorrhage or spinal cord hemorrhage\r\n* No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n* No neurosurgical resection or brain biopsy within  days prior to cycle , day 
Patients with asymptomatic treated CNS metastases may be enrolled after consultation, provided all the criteria listed above are met as well as the following:\r\n* Radiographic demonstration of improvement upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study\r\n* No stereotactic radiation or whole-brain radiation within  days prior to cycle , day \r\n* Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids
Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases are excluded, with the following exceptions:\r\n* Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:\r\n** Evaluable or measurable disease outside the CNS\r\n** No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within  mm of the optic apparatus (optic nerves and chiasm)\r\n** No history of intracranial hemorrhage or spinal cord hemorrhage\r\n** No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted\r\n** No neurosurgical resection or brain biopsy within  days prior to cycle , day \r\n* Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:\r\n** Radiographic demonstration of improvement upon the completion of CNS directed therapy and no evidence of interim progression between the completion of CNS directed therapy and the screening radiographic study\r\n** No stereotactic radiation or whole-brain radiation within  days prior to Cycle , Day \r\n** Screening CNS radiographic study >=  weeks from completion of radiotherapy and >=  weeks from discontinuation of corticosteroids
Untreated or active central nervous system (CNS) metastases (progressing or requiring anticonvulsants or corticosteroids for symptomatic control); patients with a history of treated CNS metastases are eligible, provided that all of the following criteria are met:\r\n* Presence of measurable or evaluable disease outside of the CNS;\r\n* Radiographic demonstration of improvement upon completion of CNS-directed therapy and no evidence of interim progression between completion of CNS-directed therapy and the screening radiographic study\r\n* Completion of radiotherapy >=  weeks prior to the screening radiographic study\r\n* Discontinuation of corticosteroids and anticonvulsants >=  weeks prior to the screening radiographic study
Known untreated or active central nervous system (CNS) metastases (progressing or requiring anticonvulsants or corticosteroids for symptomatic control); patients with a history of treated CNS metastases are eligible, provided that they meet all of the following criteria:\r\n* Presence of measurable disease outside the CNS\r\n* No radiographic evidence of worsening upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study\r\n* No history of intracranial hemorrhage or spinal cord hemorrhage\r\n* No ongoing requirement for dexamethasone as therapy for CNS disease (anticonvulsants at a stable dose are allowed)\r\n* Absence of leptomeningeal disease
Untreated or active central nervous system (CNS) metastases (progressing or requiring anticonvulsants or corticosteroids for symptomatic control); patients with a history of treated CNS metastases are eligible, provided that all of the following criteria are met:\r\n* Presence of measurable or evaluable disease outside of the CNS;\r\n* Radiographic demonstration of improvement upon completion of CNS-directed therapy and no evidence of interim progression between completion of CNS-directed therapy and the screening radiographic study;\r\n* Completion of radiotherapy >=  weeks prior to the screening radiographic study;\r\n* Discontinuation of corticosteroids and anticonvulsants >=  weeks prior to the screening radiographic study
Symptomatic or untreated central nervous system (CNS) metastases; patients with a history of treated asymptomatic CNS metastases are eligible, provided they meet all of the following criteria: no evidence of interim progression between the completion of CNS-directed therapy and the start of trial therapy; no ongoing requirement for dexamethasone as therapy for CNS disease; anticonvulsants at a stable dose are allowed; completed stereotactic radiation at least  week prior to cycle , day  or whole-brain radiation at least  weeks prior to cycle , day 
Untreated or active central nervous system (CNS) metastases. Patients with a history of treated CNS metastases are eligible, provided that they meet all of the following criteria: evaluable or measurable disease outside the CNS, radiographic demonstration of improvement upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study, and screening CNS radiographic study is >/=  weeks since completion of radiotherapy and >/=  weeks since the discontinuation of corticosteroids and anticonvulsants
Known central nervous system (CNS) disease, except for treated asymptomatic CNS metastases, provided all of the following criteria are met: measurable disease outside the CNS, only supratentorial metastases allowed (i.e., no metastases to midbrain, pons, medulla, or spinal cord), no evidence of progression or hemorrhage after completion of CNS-directed therapy, no ongoing requirement for dexamethasone as therapy for CNS disease (anticonvulsants at a stable dose are allowed), no stereotactic radiation within  days or whole-brain radiation within  days prior to randomization
Participants with treated asymptomatic central nervous system (CNS) metastases are eligible, provided they meet all of the following criteria: * Evaluable or measurable disease outside the CNS * No metastases to midbrain, pons, medulla, or within  mm of the optic apparatus (optic nerves and chiasm) * No history of intracranial or spinal cord hemorrhage * No ongoing requirement for corticosteroid as therapy for CNS disease; anti-convulsants at a stable dose are allowed * No evidence of significant vasogenic edema * No stereotactic radiation, whole-brain radiation or neurosurgical resection within  weeks prior to Cycle , Day  * Radiographic demonstration of interim stability (i.e., no progression) between the completion of CNS-directed therapy and the screening radiographic study * Screening CNS radiographic study >/= weeks since completion of radiotherapy or surgical resection and >/= weeks since discontinuation of corticosteroids