Subjects receiving monoamine oxidase (MAO) inhibitors within days of study enrollment (epacadostat increases serotonin levels, theoretically increasing the risk of serotonin syndrome, although this has not been reported in any ongoing clinical studies to date) Patients requiring treatment with other anti-depressive medications including the selective and non-selective monoamine oxidase (MAO) inhibitors (including linezolid), hydroxytryptamine (HT) receptor agonists (triptans), tryptophan or antidopaminergic agents (anti-psychotics, metoclopramide, promethazine, haloperidol) Receipt of monoamine oxidase inhibitors (MAOIs), UGTA inhibitors, or melatonin supplements Has had monoamine oxidase inhibitors within days before screening Have contraindications to the use of pressor agents (e.g., SC epinephrine), notably monoamine oxidase inhibitor (MAOI) use. Concurrent therapy with monoamine oxidase inhibitors (MAOI), selective serotonin reuptake inhibitors (SSRI), or other tricyclic antidepressants (TCA) or use within weeks study start Receipt of monoamine oxidase inhibitors (MAOIs) within days before first dose of study treatment Patients must not be taking any contraindicated medications listed on the duloxetine package insert including the following: phenothiazines, propafenone, flecainide, linezolid, or anticoagulation medication (e.g., heparin, warfarin); treatment with monoamine oxidase (MAO) inhibitor within days prior to registration Patients who are receiving monoamine oxidase (MAO) inhibitors Part : on monoamine oxidase inhibitors, tricyclic antidepressants, or clonidine Has received monoamine oxidase inhibitors within days prior to starting study Current use of selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), monoamine oxidase (MAO) inhibitor, tramadol or trazadone; or use of these agents within days Use of monoamine oxidase inhibitors (MAOI)s and selective serotonin reuptake inhibitor (SSRIs) within the last weeks or history of serotonin syndrome Therapy with monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitor (SSRIs) within the last weeks or history of serotonin syndrome Monoamine oxidase (MAO) inhibitor use within the past weeks or prior evidence of serotonin syndrome Monoamine oxidase inhibitors. Patients taking monoamine oxidase (MAO)-inhibitors or antipsychotic medications Patient has taken monoamine oxidase inhibitors (MAOI) in the past two weeks Concurrent therapy with a Selective Serotonin Reuptake Inhibitor (SSRI), tricyclic antidepressant, or Monoamine Oxidase Inhibitor (MAOi); clinical judgment should be used in a decision to discontinue antidepressants; a minimum of a week washout period is required for any tricyclic or related antidepressant, or any SSRI ( weeks for paroxetine or sertraline, weeks for fluoxetine); minimum week washout for any MAOi Patients who discontinue monoamine oxidase (MAO)-inhibitor (I)s within days prior to starting the investigational drug Concurrent use of monoamine oxidase inhibiting (MAOI) medication. Patient is currently receiving or has received another investigational agent within days or monoamine oxidase inhibitor within days prior to Lazanda administration Recently started on anti-depressant medications (past one month for those on selective serotonin reuptake inhibitors [SSRI] and past two months for those started on monoamine oxidase inhibitors [MAOI]) Patients taking monoamine oxidase (MAO) inhibitors, tricyclic antidepressants, clonidine, psychostimulants, concurrent steroids or other medications specifically for fatigue Use of monoamine oxidase inhibitors (MAOI) inhibitors History of grade depression or anxiety or treatment with antidepressants, antipsychotics or monoamine oxidase inhibitor (MAO) inhibitors within days of registration Need monoamine oxidase inhibitors, tricyclic antidepressants, or clonidine Need monoamine oxidase inhibitors, tricyclic antidepressants, or clonidine Currently receiving phenobarbital, diphenylhydantoin, primidone, phenylbutazone, monoamine oxidase inhibitors (MAOIs), clonidine and tricyclic antidepressant drugs Current use or use within past two weeks of an monoamine oxidase inhibitor (MAOI) Previous therapy with urate oxidase Use of monoamine oxidase inhibitors within days of study entry