Eastern Cooperative Oncology Group (ECOG) performance status =< (Karnofsky >= %) and life expectancy greater than months; furthermore, enrollment of patients with greater than measurable lesions is discouraged Eastern Cooperative Oncology Group (ECOG) performance status ? and minimum life expectancy of weeks Patients must have Eastern Cooperative Oncology Group (ECOG) performance status =< and a life expectancy of at least months Patients must have Eastern Cooperative Oncology Group (ECOG) performance status -\r\n* NOTE: Participants with impaired decision-making capacity (IDMC) should not be allowed to participate in this study due to its complexity Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status =< Eastern Cooperative Oncology Group (ECOG) performance status of zero to two unless decline is due to bony disease ELIGIBILITY CRITERIA - PHASE I (ARMS A, B, C): Eastern Cooperative Oncology Group (ECOG) performance status - Patients must be ambulatory with good performance status (Eastern Cooperative Oncology Group [ECOG] or ) INCLUSION CRITERIA FOR SECOND-LINE THERAPY: Eastern Cooperative Oncology Group (ECOG) performance status or SAFETY RUN-IN: Eastern Cooperative Oncology Group (ECOG) performance status - Eastern Cooperative Oncology Group (ECOG) performance status of to and Life expectancy of at least weeks Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of - Performance status of Eastern Cooperative Oncology Group (ECOG) -; patients with ECOG of may be allowed to enroll after discussion with the regulatory-sponsor/principal investigator and medical monitor, and if the performance status is believed to be secondary to lymphoma related symptoms and performance status is expected to improve once chemotherapy commences Patients must exhibit a/an Eastern Cooperative Oncology Group (ECOG) performance status of - ENROLLMENT TO THE DOSE ESCALATION, EXPANSION AND PART II: Eastern Cooperative Oncology Group (ECOG) performance status =< Must have Eastern Cooperative Oncology Group (ECOG) Performance Status of or , assessed within days prior to randomization. Two observers qualified to perform assessment of the performance status will be required to perform this assessment. If discrepant, the one with the most deteriorated performance status will be considered true. Eastern Cooperate Oncology Group (ECOG) performance status =< Eastern Collaborative Oncology Group (ECOG) performance status of or at screening Eastern Cooperative Oncology Group (ECOG) performance status of ? , measured within hours before the start of treatment. Eastern Collaborative Oncology Group (ECOG) Performance Status of ? Eastern Cooperative Oncology Group (ECOG) performance status of - with no clinical deterioration over the previous weeks and likely able to complete at least weeks of treatment. European Cooperative Oncology Group (ECOG) performance status or . Eastern Cooperative Oncology Group Performance Status (ECOG PS) of or . . Subjects must have adequate hematopoietic, liver, renal and coagulation function as assessed by specific laboratory criteria. Performance status: Eastern Cooperative Oncology Group (ECOG) - and life expectancy >= year Eastern Cooperative Oncology Group (ECOG) performance status of or and minimum life expectancy of ? months Eastern Cooperative Oncology Group (ECOG) performance status =< (Karnofsky >= %) is required for eligibility; those patients with lower performance status based solely on bone pain secondary to multiple myeloma are eligible Eastern Cooperative Oncology Group (ECOG) performance status =< ; performance status of will be accepted if impairment is caused by DLBCL complications and improvement is expected once therapy is initiated Eastern Cooperative Oncology Group (ECOG) performance status =< (Phase I), =< (Phase II) Eastern cooperative oncology group (ECOG) performance status ? and life expectancy > weeks Clinical performance status of Eastern Cooperative Oncology Group (ECOG) or at enrollment and within days of initiating lymphodepleting chemotherapy. Eastern Cooperative Oncology Group performance status - at time of informed consent Eastern Cooperative Oncology Group (ECOG) performance status of or , and estimated life expectancy of ? months COHORT : HORMONE RECEPTOR POSITIVE BREAST CANCER: Eastern Cooperative Oncology Group (ECOG) performance status or Patients must be medically fit to undergo surgery as determined by the treating medical and surgical oncology team and have Eastern Cooperative Oncology Group (ECOG) performance status -. An eastern cooperative oncology group performance status (ECOG PS) of to at screening and adequate hematological, renal and hepatic function as defined by protocol specified criteria. Has Eastern Cooperative Oncology Group (ECOG) performance status of or , with no deterioration over the previous weeks. Eastern Cooperative Oncology Group (ECOG) performance status of -, however grade patients may be enrolled at the discretion of the treating radiation oncologist Eastern Cooperative Oncology Group (ECOG) performance status =< for patients treated in the expansion phase; ECOG performance status (PS) =< is required for participants in the dose-finding portion of the study Eastern Cooperative Oncology Group (ECOG) performance status of -; able to understand and sign the Informed Consent document Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) status of -\r\n* NOTE: ECOG performance status will be allowed only if thought to be directly secondary to adenoid cystic carcinoma disease by treating physician Eastern Cooperative Oncology Group (ECOG) performance status =< (There may be certain patients with performance status [PS] in the context of rapidly proliferative/refractory ALL who would benefit from this regimen. We dont want to exclude such patients who may derive benefit from this salvage regimen) Eastern Co-operative Oncology Group (ECOG) performance status < or = . Eastern Cooperative Oncology Group (ECOG) performance status =< for MSS participants or < for microsatellite instability (MSI) participants Has an Eastern Cooperative Oncology Group (ECOG) performance status of or at initial screening and at baseline. Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of =< Eastern Cooperative Oncology Group (ECOG) performance status to ; (performance status of will be allowed if poor performance status is thought to be directly secondary to ALL) Eastern Cooperative Oncology Group (ECOG) performance status or with no deterioration over the previous weeks and an estimated life expectancy of greater than weeks Eastern Cooperative Oncology Group (ECOG) performance status of or ; patients with an ECOG performance status of will be allowed at the discretion of the treating investigator in agreement with the sponsor-investigator Participant has an Eastern Cooperative Oncology Group (ECOG) Performance Status of to for Monotherapy and to for Combination. Eastern Cooperative Oncology Group (ECOG) performance status of =< or greater, based on treating physicians discretion European Cooperative Oncology Group (ECOG) performance status or Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) status of -; ECOG performance status and will be allowed only if decline in performance status is thought to be directly secondary to breast cancer disease burden by treating physician Eastern Cooperative Oncology Group (ECOG) performance status =< or expected survival duration of > months Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of , , or Eastern Cooperative Oncology Group (ECOG) performance status of =< and fit for induction therapy in the opinion of the treating physician History/physical examination, including breast exam and documentation of weight and Eastern Cooperative Oncology Group (ECOG) performance status Adult patients with an Eastern Cooperative Oncology Group (ECOG) performance status - and a life expectancy of months or more The subject must have a performance status of - as determined by criteria set forward by the Eastern Cooperative Oncology Group Eastern Co-operative Oncology Group (ECOG) performance status of ? . CAPMATINIB INCLUSION CRITERIA: Eastern Cooperative Oncology Group (ECOG) performance status - Eastern Cooperative Oncology Group (ECOG) performance status and/or other performance status , , or ; performance status of permissible if related to disease Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of =< Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of - Eastern Cooperative Oncology Group performance status must be or , and life expectancy should be approximately months or more. Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of - PHASE I STUDY ELIGIBILITY CRITERIA:\r\nEastern Cooperative Oncology Group (ECOG) performance status =< Southwest Oncology Group (SWOG) performance status >= . Patients with Eastern Cooperative Oncology Group (ECOG) performance status worse than (ie unable to perform their own activities of daily living [ADLs] without assistance, unable to spend less than % of day out of bed) Eastern Cooperative Oncology Group (ECOG) performance status of zero, one, or two Eastern Cooperative Oncology Group (ECOG) performance status ( if it is directly disease related and is expected to get better if the acute lymphoblastic leukemia/lymphoma [ALL] is under control) Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of or (performance status of will be allowed if poor performance status is thought to be directly secondary to patients Hodgkin lymphoma [HL]) Adequate performance status (Eastern Cooperative Oncology Group [ECOG] < ) and research participant does not require mechanical ventilation Eastern Clinical Oncology Group performance status or Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of or Eastern Clinical Oncology Group performance status or Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN) performance status between - Relapsed/refractory MCL: Eastern Cooperative Oncology Group (ECOG) performance status of or less Newly diagnosed MCL: Eastern Cooperative Oncology Group (ECOG) performance status of or less Patient eligible for standard induction chemotherapy based on Eastern Cooperative Oncology Group (ECOG) performance status (PS) and vital organ function at the discretion of the treating physician Subjects must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of or Eastern Cooperative Oncology Group (ECOG) performance status =< and life expectancy greater than weeks based on the investigator's clinical judgment Participants will not be excluded based on performance status; for patients with Eastern Cooperative Oncology Group (ECOG) performance status >= to the dosing schedule will be discussed with study chairman Patients > may be considered if performance status > % or Eastern Cooperative Oncology Group (ECOG) =< and comorbidity score < ; these patients must be discussed with the principal investigator (PI), Rachel Salit prior to enrollment Clinical performance status of Eastern Cooperative Oncology Group (ECOG) - (Turnstile I) Eastern cooperative oncology group (ECOG) performance status of - with a life expectancy ? months Easter Cooperative Oncology Group (ECOG) Performance Status ? Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of =< ORAL CAVITY SQUAMOUS CELL CARCINOMA COHORT: Eastern Cooperative Oncology Group (ECOG) performance status < Eastern Cooperative Oncology Group (ECOG) performance status of , , or , and estimated survival of at least months Eastern Cooperative Oncology Group (ECOG) performance status of =< and fit for induction therapy in the opinion of the treating physician Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status - Patients must have Eastern Cooperative Oncology Group (ECOG) performance status - and expected survival > months from study enrollment Eastern Cooperative Oncology Group (ECOG) performance status being - within week of planned start of therapy FOR TISSUE COLLECTION TO ESTABLISH PDX (PART ): Eastern Cooperative Oncology Group (ECOG) performance status of -. Southwest Oncology Group (SWOG) performance status - Eastern Cooperative Oncology Group (ECOG) performance status -, life expectancy > months Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of =< The subject must have a performance status of - as determined by criteria set forward by the Eastern Cooperative Oncology Group DOSE ESCALATION COHORT: Eastern Cooperative Oncology Group (ECOG) performance status - Eastern Cooperative Oncology Group (ECOG) performance status =< (Karnofsky >= %)\r\n* Exception will be made for patients with ECOG performance status =< and Karnofsky performance scale >= %, who require the use of wheelchairs, walkers or canes as well as assistance with daily routines secondary to disabilities caused by ECD cerebellar or brain disease that has been stable for >= months PSTAT SCREENING: Eastern Cooperative Oncology Group (ECOG) performance status - Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of - with greater than six week life expectancy Have an Eastern Cooperative Oncology Group (ECOG) performance status of =< (Karnofsky >= %) and a life expectancy of at least months; evaluation of ECOG is to be performed within days prior to the date of allocation/randomization Easter Cooperative Oncology Group (ECOG) performance status - Eastern Cooperative Oncology Group (ECOG) performance status of or at initial enrollment, as assessed by clinician or investigator Life expectancy of >= months, Eastern Cooperative Oncology Group (ECOG) performance status =< Clinical performance status of Eastern Cooperative Oncology Group (ECOG) - ; ECOG performance status of - will be inferred if the patients level of energy is >= % of baseline Southwest Oncology Group (SWOG) performance status >= . Clinical performance status of Eastern Cooperative Oncology Group (ECOG) - ; ECOG performance status of - will be inferred if the patient's level of energy is >= % of baseline Performance Status: Eastern Cooperative Oncology Group (ECOG) - unless mobility is limited from chronic physical handicap Eastern Cooperation Oncology Group (ECOG) performance status - Patients must have Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN) performance status of - Southwest Oncology Group (SWOG) performance status >= . Eastern Cooperative Oncology Group (ECOG) performance status of -; patients with ECOG performance status of will be eligible if the lower performance status is deemed by the investigator to be due entirely to accelerated or blastic phase MPN and not due to another comorbidity Patients who have received one prior regimen must have an Eastern Cooperative Oncology Group (ECOG) performance status of , , or ; patients who have received two or three prior regimens must have an ECOG performance status of or South Western Oncology Group (SWOG) performance status - AMKL PATIENTS: Patients must have an Eastern Cooperative Oncology Group (ECOG) status - Eastern Cooperative Oncology Group performance status superior to . Performance status with Eastern Cooperative Oncology Group (ECOG) score =< ; patients with performance status of may be considered as long as the decline has been of short duration (< month), and is due to their malignancy and not a comorbid condition (example: pain limiting activity) ECOG (Eastern Cooperative Oncology Group) Performance Status of - within days prior to registration. ECOG Performance Status of will only be allowed if judged by the treating investigator as attributable exclusively to bone pain. Eastern Cooperative Oncology Group (ECOG) performance status =< ; ECOG indicates that the patient is fully active and able to carry on all pre-disease activities without restriction; and, ECOG indicates that the patient is restricted in physically strenuous activity but is ambulatory and able to carry out work of a light or sedentary nature Eastern Cooperative Oncology Group performance status of to. For LM patients, to is acceptable. Southwestern Oncology Group (SWOG) performance status >= . Eastern Co-Operative Group (ECOG) performance status = - Easter Cooperative Oncology Group (ECOG) performance status or Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of =< Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of - Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of - Eastern Cooperative Oncology Group (ECOG) performance of - with anticipated life expectancy of >= weeks Eastern Cooperative Oncology Group (ECOG) performance status of , or as long as patients are eligible to receive chemotherapy along with concurrent radiotherapy Eastern Cooperative Oncology Group (ECOG) performance status of -. Patients with performance status are only eligible if the decline in performance status is due to metastatic prostate cancer. Eastern Cooperative Oncology Group performance status - at time of informed consent Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status: ECOG of or including patients who are not surgical candidates due to comorbid conditions Must have a radiographically or clinically evaluable solid tumor Eastern Cooperative Oncology Group (ECOG) performance status of or . Eastern Cooperative Oncology Group (ECOG) performance status or ( is allowed only if due to bone pain) Men and women ? years of age with an Eastern Cooperative Oncology Group (ECOG) performance status ? Subjects must have Eastern Cooperative Oncology Group (ECOG) performance status of , , or ; if ECOG , they must also have a Charlson comorbidity index of =< Eastern Cooperative Oncology Group (ECOG) performance status to with no deterioration over the previous weeks. A life expectancy of at least months and Eastern Cooperative Oncology Group (ECOG) performance status =< Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of - Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of -, and life expectancy >= years Eastern Cooperative Oncology Group (ECOG) performance status of to at the trial entry and an estimated life expectancy of at least months Participants must have a performance status of - based on Eastern Cooperative Oncology Group (ECOG) criteria; participants with a poor performance status (-) based solely on bone pain will be eligible, provided there is documentation to verify this Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of , , or Eastern Cooperative Oncology Group (ECOG) performance status - and life expectancy > weeks Eastern Cooperative Oncology Group (ECOG) performance status =< ; patients with ECOG performance status of (defined as being capable of only limited self-care, confined to bed or chair more than % of waking hours) will also be eligible only if the lower performance status is judged to be directly related to steroid and/or cGVHD effects Eastern Cooperative Oncology Group (ECOG) performance status =< for ages >= or Lansky play >= % for ages =< Easter Cooperative Oncology Group (ECOG) Performance Status of - Southwest Oncology Group (SWOG) performance status or Eastern Cooperative Oncology Group (ECOG) performance status of =< or greater, based on treating physician's discretion Eastern Cooperative Oncology Group (ECOG) score - (Physically able to carry out light housework or office work through to being fully active as you were before cancer) Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of - with a greater than nine week life expectancy Easter Cooperative Oncology Group (ECOG) performance status of ,,or Must have an Eastern Cooperative Oncology Group (ECOG) performance status of or , adequate organ function, and a life expectancy of ? months Life expectancy - =/> months, Eastern Cooperative Oncology Group status = or . Eastern Cooperative Oncology Group (ECOG) performance status of - and a life expectancy > weeks. Southwestern Oncology Group (SWOG) performance status or Eastern Cooperative Oncology Group (ECOG) performance status or if age less than (<) years; ECOG status of if age to years Subject can move around on their own, has an Eastern Cooperative Oncology Group (ECOG) performance status of or , and has an estimated life expectancy of at least months ECOG PS (Eastern Cooperative Group Performance Status) of or . . Ability to swallow oral capsules without difficulty. . Pregnancy Prevention Risk Management Plan: Eastern Cooperative Oncology Group (ECOG) performance status of or in Parts and dose escalation and titration, and , , in Part dose expansion Eastern Cooperative Oncology Group (ECOG) performance status -; life expectancy at least months Male or female of >= years of age with the Eastern Cooperative Oncology Group (ECOG) performance status -, Child-Pugh score of -, and Life expectancy of months or greater. European Cooperative Oncology Group (ECOG) performance status of ? Performance status of - based on the Eastern Cooperative Oncology Group (ECOG) criteria; patients with performance status or , based solely on bone pain, are also eligible, provided that there is a source document to verify this Patient has received a platinum containing regimen. Eastern Cooperative Oncology Group (ECOG) performance status -. Radiographically-documented measureable disease. Eastern Cooperative Oncology Group (ECOG) performance status: or . NOTE: Subjects with a performance status of can be enrolled if the subject's confinement to bed and inability to carry out work activities is due solely to cancer-related pain, as assessed by the Investigator. Willingness to provide consent for biopsies positive or BRAF WT measurable disease, Eastern Cooperative Oncology Group (ECOG) performance status of or , and adequate organ and marrow function Eastern Co-operative Oncology Group (ECOG) performance status of - Eastern Cooperative Oncology Group status of or lower Eastern Cooperative Oncology Group (ECOG) performance status to in Part and Part , participants enrolled in the extension/tail portion, Part and Part must have an ECOG performance status of or Patients with a Karnofsky Performance Status of % to % (or equivalent, Eastern Cooperative Oncology Group [ECOG] performance status of or ); Performance Status Evaluation), and an anticipated life expectancy of ? months. Inclusion Criteria:\n\n - Life expectancy of at least months\n\n - Histological or cytological documentation of advanced solid tumors\n\n - ECOG Performance Status of ? (ECOG: Eastern Cooperative Oncology Group)\n\n - Adequate bone marrow, liver and renal function\n\n - Women of childbearing potential and men must agree to use adequate contraception Eastern Cooperative Oncology Group (ECOG) performance status =< for run-in phase; ECOG =< for randomized phase History/physical examination, including weight and assessment of Eastern Cooperative Oncology Group (ECOG) performance status, within month of registration Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of - with greater than months life expectancy Performance status of Eastern Cooperative Oncology Group (ECOG) =< or Karnofsky >= %; note: participants with lower performance status based solely on bone pain secondary to multiple myeloma will be eligible A life expectance of at least months as evidenced by Eastern Cooperative Oncology Group (ECOG) performance status - Eastern Cooperative Oncology Group (ECOG) performance status of =< ; NOTE: For the phase I part of the study, patients with ECOG performance status will be excluded Eastern Cooperative Oncology Group Performance Status of or for Parts A and B. Subjects with Eastern Cooperative Oncology Group Performance Status of or less may be entered into Part C with approval of medical monitor. Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of =< Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of =< Eastern Cooperative Oncology Group (ECOG) performance status ? . Patients with stable ECOG scores of may be allowed with medical monitor approval. Patients with performance status of =< (Eastern Cooperative Oncology Group performance status scale, only allowed if decline in status is deemed related to lymphoma and felt potentially reversible by the treating physician) Eastern Cooperative Oncology Group (ECOG) Performance status assessed between and ; performance status of will be accepted if impairment is caused by DLBCL complications and improvement is expected once therapy is initiated PATIENT: Eastern Cooperative Oncology Group (ECOG) performance status from (asymptomatic) to (symptomatic and in bed > % of the day) Eastern Cooperative Oncology Group (ECOG) performance status from (asymptomatic) to (symptomatic and in bed < % of day) Patient is spending more than % of time out of bed on a daily basis, as measured by an Eastern Cooperative Oncology Group (ECOG) performance status rating of level , , or Eastern Cooperative Oncology Group (ECOG) performance status - during dose finding, - during MTD expansion Eastern Cooperative Oncology Group (ECOG) performance status from (asymptomatic) to (symptomatic and in bed < % of the day) Patients must exhibit an Eastern Cooperative Oncology Group (ECOG) performance status of to . At the time of recruitment, a life expectancy of greater than months and/or a Karnofsky performance status of or above or an Eastern Cooperative Oncology Group (ECOG) score of or Eastern Cooperative Oncology Group (ECOG) performance status , or at time of initial screening There will be no discrimination based on gender, race, creed, or ethnic background; Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance scale (KPS) will not be employed Eastern Cooperative Oncology Group (ECOG) performance status of - (=participant has either normal activity, = participant has some symptoms but is nearly full ambulatory) Eastern Cooperative Oncology Group (ECOG) rating of >= or Karnofsky performance status (KPS) < as rated by the oncology provider Eastern Cooperative Oncology Group (ECOG) performance status from (asymptomatic) to (symptomatic and in bed < % of the day) PATIENT: Eastern Cooperative Oncology Group (ECOG) performance status of > or Karnofsky performance status < (suggesting patient is capable of only limited self-care, confined to bed or chair more than % of waking hours, or requires considerable assistance and frequent medical care) as rated by the attending oncologist SCREENING PHASE: Eastern Cooperative Oncology Group performance status - INTERVENTION PHASE: Eastern Cooperative Oncology Group performance status - Eastern Cooperative Oncology Group (ECOG) performance status - (at the time the subject signs their first informed consent form); Easter Cooperative Oncology Group (ECOG) performance status or Eastern Cooperative Oncology Group (ECOG) ranging from (asymptomatic) to (symptomatic and in bed > % of the day) Eastern Cooperative Oncology Group (ECOG) performance status of - at Screening or by the day chemotherapy is initiated Have an Eastern Cooperative Oncology Group (ECOG) Performance Status of , , or . However, potential subjects with an ECOG of may be enrolled provided their condition does not preclude performing the actions required by study participation (e.g., opening medication bottles, swishing the oral rinse and spitting out, completing or participating in completion of daily diaries and FACT-H&N forms). Eastern Cooperative Oncology Group (COG) performance status of - Eastern Cooperative Oncology Group (ECOG) performance status or (fully active or restricted only in physically strenuous activity) Southwestern Oncology Group (SWOG) performance status of The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of - or, based on judgment of the treating medical oncologist, can tolerate imaging and at least months of ET Eastern Cooperative Oncology Group (ECOG) or Karnofsky performance status will not be employed, but patients will need to be sufficiently healthy to tolerate all study procedures AIM : Participants must be Eastern Cooperative Oncology Group (ECOG) status - Has Eastern Cooperative Oncology Group (ECOG) performance status of or , with no deterioration over the previous weeks Easter Cooperative Oncology Group (ECOG) performance status or Non-metastatic GI cancers are eligible only if the Eastern Cooperative Oncology Group (ECOG) performance status is , , or at the time of consent (although patients with locally advanced [stage III] and inoperable pancreatic cancers are eligible regardless of their performance status) Women and men ? years of age with Eastern Cooperative Oncology Group (ECOG) performance status of or The patient must have recovered from surgery with the incision completely healed and no signs of infection; if adjuvant chemotherapy was administered, chemotherapy-related toxicity that may interfere with delivery of radiation therapy should have resolved; the patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of or (Karnofsky performance status [KPS] > %)