Patients with porphyria or psoriasis are ineligible unless the disease is well controlled and they are under the care of a specialist for the disorder who agrees to monitor the patient for exacerbations Subjects with a history of the light sensitive diseases for which methoxsalen would be contraindicated. Diseases associated with photosensitivity include lupus erythematosus, porphyria cutanea tarda, erythropoietic protoporphyria, variegate porphyria, xeroderma pigmentosum, and albinism. Those with porphyria or with known hypersensitivity to porphyrins or porphyrin-like compounds Porphyria or known hypersensitivity to Photofrin or porphyrin-like compounds or to any of its excipients Patients with porphyria or hypersensitivity to porphyrin or porphyrin-like compounds History of sun hypersensitivity and photosensitive dermatoses including porphyria, systemic lupus erythematosus, Sjgren's syndrome, xeroderma pigmentosum, polymorphous light eruptions or radiation therapy within days of enrolling. Diagnosed with Acute Hepatic Porphyria (Acute Intermittent Porphyria, Hereditary Corproporhyria, Variegate Porphyria, ALA dehydratase deficient porphyria) Have active disease, with at least documented porphyria attacks within the last months Photosensitivity disorder, including but not limited to porphyria, or concomitant photosensitizing drugs that place the patient at an elevated risk of developing severe side effects to PDT or RT Patients with porphyria are not eligible Patients with porphyria are ineligible Patients with porphyria, or with known hypersensitivity to porphyrins or porphyrin-like compounds History of photosensitizing disease (porphyria, lupus etc.) or of allergy to methylene blue dye. Patients with history of a photosensitivity disease, such as porphyria cutanea tarda Patients with a lifetime history of porphyria or psoriasis Must not have psoriasis or porphyria Patients with porphyria are not eligible Due to risk of disease exacerbation patients with porphyria are not eligible Porphyria Patients must not have psoriasis or porphyria Patients with porphyria cutanea tarda Porphyria or hypersensitivity to porphyrins (constituents of porfimer sodium), gemcitabine, cisplatin or other platinum-containing compounds Patients with porphyria, or with known hypersensitivity to porphyrins or porphyrin-like compounds History of porphyria. Patients with porphyria, or with known hypersensitivity to porphyrins or porphyrin-like compounds Porphyria (possibility of triggering a porphyric reaction) History of gastrointestinal or genitourinary obstruction or porphyria History of gastrointestinal or genitourinary obstruction or porphyria Cutaneous photosensitivity to wavelengths of - nm, porphyria or known allergies to porphyrins Individuals with history of cutaneous photosensitivity, porphyria, hypersensitivity to porphyrins, photodermatosis, exfoliative dermatitis History of cutaneous photosensitivity, porphyria, hypersensitivity to porphyrins, photodermatosis, exfoliative dermatitis Is experiencing photo-toxicity or photo-sensitivity or is undergoing treatment for a photo-sensitive condition such as porphyria or lupus erythematosus;