Current symptomatic pulmonary embolism Prior or concurrent pulmonary embolism Pulmonary embolism within days prior to study entry Pulmonary embolism Symptomatic pulmonary embolism within months prior to study entry Any known uncontrolled cardiovascular disease, pulmonary embolism, hypertension not adequately controlled by standard medications within months prior to enrollment. Pulmonary embolism (PE) in the months before enrollment; anticoagulation is permitted as long as stable dosage for more than months Pulmonary embolism. ENTRECTINIB EXCLUSION CRITERIA: Pulmonary embolism in the months prior to study drug administration Subjects with a history of pulmonary embolism are excluded Pulmonary embolism Has a history of blood clots, pulmonary embolism, or DVT unless controlled by anticoagulant treatment Patients with any prior history of arterial thrombosis or symptomatic pulmonary embolism Pulmonary embolism Previous history of pulmonary embolism or pulmonary embolism found on screening exam. Any other serious cardiac illness or medical conditions such as unstable angina, pulmonary embolism, or uncontrolled hypertension. Any other serious cardiac illness or medical conditions such as unstable angina, pulmonary embolism, or uncontrolled hypertension Pulmonary embolism. Pulmonary embolism within months before screening Pulmonary embolism on active therapy History of arterial or venous embolism within months prior to study enrollment. If the embolism occurred > and < months, the participant is eligible provided appropriate treatment according to institutional standard of care is ensured. Previous history of pulmonary embolism or pulmonary embolism found on screening exam. Previous pulmonary embolism within months before study entry Previous pulmonary embolism within months prior to study entry Pulmonary embolism (PE) within the last months prior to registration Diagnosis of acute pulmonary embolism within past weeks Participant has had pulmonary embolism or any other thrombo-embolic event within months prior to study entry Diagnosis of acute pulmonary embolism within past weeks acute pulmonary embolism or pulmonary infarction, Participants with type diabetes, documented stomach ulcers and pulmonary embolism