No history of any prior stroke (hemorrhagic or ischemic) History of grade III hemorrhagic cystitis due to prior cyclophosphamide chemotherapy History or evidence of thrombotic or hemorrhagic disorders within months before first study treatment TREATMENT EXCLUSION: Active hemorrhagic cystitis Any history of hemorrhagic stroke Major hemorrhagic event within days Patients with prior history of ventilator support related to lung injury such as pneumonia, hemorrhagic pneumonitis, capillary leakage are excluded History of ventilator support related to lung injury (e.g., pneumonia, hemorrhagic pneumonitis, capillary leakage) History of hemorrhagic or ischemic stroke within the last months History or evidence of thrombotic or hemorrhagic disorders within months before first study treatment Current thrombotic or hemorrhagic disorder/event or history of prior event within months of start of screening History of hemorrhagic CNS metastases Subjects with active hemorrhagic diathesis Known history of hereditary hemorrhagic telangiectasia (HHT). MPD: Patients with polycythemia vera with persistent thrombotic or hemorrhagic complications despite conventional therapy, or who have progressed to postpolycythemic marrow fibrosis History of thrombotic or hemorrhagic stroke or myocardial infarction within months. History of Osler-Weber-Rendu syndrome or hereditary hemorrhagic telangiectasia Uncontrolled thromboembolic or hemorrhagic disorders. History of congenital bleeding diathesesor anatomical anomaly that predisposes to hemorrhage (e.g. hemophilia, hereditary hemorrhagic telangiectasia). Resolving hemorrhagic changes related to surgery. Uncontrolled thrombotic or hemorrhagic disorder Patients with hemorrhagic brain metastases Patients with known allergy to etoposide or a history of grade hemorrhagic cystitis with cyclophosphamide are not eligible Patients with a history of thrombotic or hemorrhagic disorders History of hemorrhagic or ischemic stroke within months prior to first dose of mirvetuximab soravtansine History or evidence of thrombotic or hemorrhagic disorders within months prior to first dose of mirvetuximab soravtansine Hemorrhagic, embolic, or thrombotic stroke within months of scheduled dosing day ; History of hereditary hemorrhagic telangiectasia (HHT, Osler-Weber-Rendu syndrome) Hereditary or chronic hemorrhagic or coagulopathy conditions (i.e., hemophilia) Known bleeding diathesis Known history of hereditary hemorrhagic telangiectasia (HHT). Patients with a history of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome) No history of hemorrhagic stroke Documented hemorrhagic tendencies Documented hemorrhagic tendencies (e.g., hemophilia) History of bleeding disorder or hemorrhagic stroke History of bleeding disorder or hemorrhagic stroke Hemorrhagic cystitis or active prostatitis Patient must not have hemorrhagic lesions History of thrombotic or hemorrhagic stroke or myocardial infarction within months