Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the defined eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive\r\n** At least  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Hematopoietic growth factors: At least  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil count [ANC] counts): At least  days after the last dose of agent\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* External beam radiation therapy (XRT)/external beam irradiation including protons: >=  days after local XRT; >=  days after total body irradiation (TBI), craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial bone marrow (BM) radiation.\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, I-MIBG): >=  days must have elapsed since systemically administered radiopharmaceutical therapy\r\n* Stem cell infusion (with or without TBI):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion, no evidence of graft versus host disease (GVHD) and no requirement for immunosuppression\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular therapy: >=  days must have elapsed since the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* Patients must not have received prior exposure to nivolumab; for patients enrolled in parts C, D and E, patients must not have received prior nivolumab or ipilimumab
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the defined eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator prior to enrollment\r\n** >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil count [ANC] counts): >=  days must have elapsed from last dose of agent; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator prior to enrollment\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: If used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid \r\n* Hematopoietic growth factors: >=  days must have elapsed since the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days must have elapsed since the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell infusions (with or without total body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days must have elapsed after infusion, and no evidence of graft-versus-host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days must have elapsed after completion\r\n* Cellular therapy: >=  days must have elapsed since the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* X ray (XRT)/external beam irradiation including protons: >=  days must have elapsed after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial bone marrow (BM) radiation\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody,  iodine metaiodobenzylguanidine [I-MIBG]): >=  days must have elapsed since systemically administered radiopharmaceutical therapy\r\n* Patients must not have received prior exposure to LY
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Myelosuppressive chemotherapy: At least  days after the last dose of myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Hematopoietic growth factors: At least  days after the last dose of a long-acting growth factor (e.g. Neulasta) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Biologic (anti-neoplastic agent): At least  days after the last dose of a biologic agent; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Immunotherapy: At least  days after the completion of any type of immunotherapy, e.g. tumor vaccines\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: If used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* External beam radiation therapy (XRT): At least  days after local palliative XRT (small port); at least  days must have elapsed if prior total body irradiation (TBI), craniospinal XRT or if >= % radiation of pelvis; at least  days must have elapsed if other substantial bone marrow (BM) radiation\r\n* Stem cell infusion without TBI: No evidence of active graft vs. host disease and at least  days must have elapsed after transplant or stem cell infusion\r\n* Patients must not have received prior exposure to selinexor
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required time frame, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive; at least  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea); the duration of this interval must be discussed with the study chair and the study-assigned research coordinator prior to enrollment\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil counts [ANC] counts): >=  days after the last dose of agent; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator prior to enrollment\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: if used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* Hematopoietic growth factors: >=  days after the last dose of a long-acting growth factor (e.g. Neulasta) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell Infusions (with or without total body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* Radiation therapy (XRT)/external beam irradiation including protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial brain metastases (BM) radiation\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, I-metaiodobenzylguanidine [MIBG]): >=  days after systemically administered radiopharmaceutical therapy\r\n* Patients must not have received prior exposure to pevonedistat; patients with prior exposure to irinotecan or temozolomide are eligible
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive\r\n** >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil count [ANC] counts): >=  days after the last dose of agent\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: If used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* Hematopoietic growth factors: >=  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for growth factors that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell infusions (with or without total body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* Radiation therapy (XRT)/external beam irradiation including protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial bone marrow (BM) radiation\r\n** Note: Radiation may not be delivered to measurable disease tumor site(s) being used to follow response to subprotocol treatment\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, iodine [I]-MIBG): >=  days after systemically administered radiopharmaceutical therapy\r\n* Patients must not have received prior exposure to olaparib, veliparib, niraparib, rucaparib, talazoparib or other poly adenosine diphosphate ribose polymerase inhibitors (PARPi)
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive; >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil count [ANC] counts): >=  days after the last dose of agent\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: if used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* Hematopoietic growth factors: >=  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for growth factors that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell infusions (with or without total body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* X-ray therapy (XRT)/external beam irradiation including protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial bone marrow (BM) radiation\r\n** Note: radiation may not be delivered to measurable disease tumor site(s) being used to follow response to subprotocol treatment\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, iobenguane I- [I-MIBG]): >=  days after systemically administered radiopharmaceutical therapy\r\n* Patients must not have received prior exposure to JNJ- (erdafitinib) or another FGFR inhibitor such as (but not limited to) AZD, BGJ, BAY, LY
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive\r\n** >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil count [ANC] counts): >=  days after the last dose of agent\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: If used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* Hematopoietic growth factors: >=  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for growth factors that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell Infusions (with or without total-body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* Radiation therapy (XRT)/external beam irradiation including protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial bone marrow (BM) radiation; Note: Radiation may not be delivered to measurable disease tumor site(s) being used to follow response to subprotocol treatment\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, iobenguane I- [I-MIBG]): >=  days after systemically administered radiopharmaceutical therapy\r\n* Patients must not have received prior exposure to a BRAF inhibitor (e.g. vemurafenib, dabrafenib or encorafenib)
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive: >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil counts [ANC] counts): >=  days after the last dose of agent\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: if used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* Hematopoietic growth factors: >= days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for growth factors that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell Infusions (with or without total body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, NK cells, dendritic cells, etc.)\r\n* Radiation therapy (XRT)/external beam irradiation including protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial none marrow (BM) radiation\r\n** Note: Radiation may not be delivered to measurable disease tumor site(s) being used to follow response to subprotocol treatment\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, I-MIBG): >=  days after systemically administered radiopharmaceutical therapy\r\n* Patients must not have received prior exposure to ensartinib; prior treatment with other ALK inhibitors is permitted given that at least  half-lives or  days have elapsed since therapy discontinuation, whichever is greater
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required time frame, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive; for agents not listed, the duration of this interval must be discussed with the study chair and the study-assigned research coordinator prior to enrollment\r\n** >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\t\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or ANC counts): >=  days after the last dose of agent; for agents not listed, the duration of this interval must be discussed with the study chair and the study-assigned research coordinator prior to enrollment\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: if used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* Hematopoietic growth factors: >=  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for growth factors that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell Infusions (with or without total body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor leukocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, NK cells, dendritic cells, etc.)\r\n* Radiation therapy (XRT)/external beam irradiation including protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial brain metastases (BM) radiation; Note: radiation may not be delivered to measurable disease tumor site(s) being used to follow response to subprotocol treatment\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, I-MIBG): >=  days after systemically administered radiopharmaceutical therapy\r\n* Patients must not have received prior exposure to other NTRK inhibitors including but not limited to LOXO- (larotrectinib), entrectinib (RXDX-), DS, PLX
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive; >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil count [ANC] counts): >=  days after the last dose of agent\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: if used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* Hematopoietic growth factors: >=  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for growth factors that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell Infusions (with or without total body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* Radiation therapy (XRT)/external beam irradiation including protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial bone marrow (BM) radiation\r\n** Note: radiation may not be delivered to measurable disease tumor site(s) being used to follow response to subprotocol treatment\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, iobenguane I- [I-MIBG]): >=  days after systemically administered radiopharmaceutical therapy\r\n* Patients must not have received prior exposure to LY\r\n* Patients must not have received prior exposure to an agent specifically directed at the PIK/MTOR pathway (a PIK inhibitor, an AKT inhibitor, an MTOR inhibitor, including rapalogs, or a combined PIK/MTOR inhibitor)
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive\r\n** >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil count [ANC] counts): >=  days after the last dose of agent\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: If used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* Hematopoietic growth factors: >=  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell Infusions (with or without total body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular Therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* Radiation Therapy (XRT)/External Beam Irradiation including Protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial bone marrow (BM) radiation\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, I-MIBG): >=  days after systemically administered radiopharmaceutical therapy
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy\r\n* Myelosuppressive chemotherapy: at least  days after the last dose of myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Hematopoietic growth factors: at least  days after the last dose of a long-acting growth factor (e.g. Neulasta) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Biologic (anti-neoplastic agent): at least  days after the last dose of a biologic agent; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Immunotherapy: at least  days after the completion of any type of immunotherapy, e.g. tumor vaccines\r\n* Monoclonal antibodies: at least  half-lives of the antibody after the last dose of a monoclonal antibody\r\n* Radiation therapy (XRT): at least  days after local palliative XRT (small port); at least  days must have elapsed if prior total body irradiation (TBI), craniospinal XRT or if >= % radiation of pelvis; at least  days must have elapsed if other substantial bone marrow (BM) radiation\r\n* Stem cell infusion without TBI: no evidence of active graft vs host disease and at least  days must have elapsed after transplant or stem cell infusion\r\n* Patients must not have received prior exposure to ramucirumab
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the defined eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator prior to enrollment\r\n** Solid tumor patients: >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n** Lymphoma patients: a waiting period prior to enrollment is not required for patients receiving standard cytotoxic maintenance chemotherapy (i.e. corticosteroid, vincristine, thioguanine[MP], and/or methotrexate)\r\n** >= days must have elapsed after the completion of other cytotoxic therapy, with the exception of hydroxyurea, for patients not receiving standard maintenance therapy; additionally, patients must have fully recovered from all acute toxic effects of prior therapy; Note: cytoreduction with hydroxyurea must be discontinued >=  hours prior to the start of protocol therapy\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil count [ANC] counts): >=  days must have elapsed from the last dose of agent; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator prior to enrollment\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Hematopoietic growth factors: >=  days must have elapsed from the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days must have elapsed from the last dose of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell infusions (with or without traumatic brain injury [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days must have elapsed from infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days must have elapsed from infusion\r\n* Cellular therapy: >=  days must have elapsed from last dose of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* External beam radiation (XRT)/external beam irradiation including protons: >=  days must have elapsed after local XRT; >=  days after TBI, craniospinal XRT or if radiation to % of the pelvis; >=  days if other substantial bone marrow (BM) radiation\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, iobenguane I- [I-MIBG]): >=  days must have elapsed from the last dose of systemically administered radiopharmaceutical therapy\r\n* Histone deacetylase (HDAC) inhibitors: Patients must not have received prior therapy with entinostat; patients who have received therapy with other HDAC inhibitors are eligible
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive\r\n** >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil counts [ANC] counts): >=  days after the last dose of agent\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: If used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* Hematopoietic growth factors: >=  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for growth factors that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell infusions (with or without total body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* Radiation therapy (XRT)/external beam irradiation including protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial bone morrow (BM) radiation\r\n** Note: Radiation may not be delivered to measurable disease tumor site(s) being used to follow response to subprotocol treatment\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, I-MIBG): >=  days after systemically administered radiopharmaceutical therapy\r\n* Patients must not have received prior exposure to palbociclib, ribociclib, abemaciclib or any other CDK/ inhibitors
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive: >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil count [ANC] counts): >=  days after the last dose of agent\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: if used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* Hematopoietic growth factors: >=  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for growth factors that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell Infusions (with or without total body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* X-ray therapy (XRT)/external beam irradiation including protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial bone marrow (BM) radiation\r\n** Note: radiation may not be delivered to measurable disease tumor site(s) being used to follow response to subprotocol treatment\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, iodine I  metaiodobenzylguanidine [I-MIBG]): >=  days after systemically administered radiopharmaceutical therapy\r\n* Patients must not have received prior exposure to selumetinib (AZD hydrogen sulfate)
Prior therapy:\r\n* Subjects must have fully recovered from the acute toxic effects of all prior anti-cancer chemotherapy\r\n** Myelosuppressive chemotherapy: at least  days after the last dose of myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n** Hematopoietic growth factors: at least  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n** Biologic (anti-neoplastic agent): at least  days after the last dose of a biologic agent; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n** Immunotherapy: at least  days after the completion of any type of immunotherapy, e.g. tumor vaccines \r\n** Antibodies: >  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade <  \r\n** External beam radiation therapy (XRT): at least  days after local palliative XRT (small port);  weeks must have elapsed since treatment with therapeutic doses of iodine -metaiodobenzylguanidine (I-MIBG); at least  days must have elapsed if prior total body irradiation (TBI), craniospinal XRT, or if >= % radiation of pelvis; at least  days must have elapsed if other substantial bone marrow (BM) radiation\r\n** Stem cell infusion without TBI: no evidence of active graft vs. host disease and at least  days must have elapsed after transplant and  days for autologous stem cell infusion after I-MIBG therapy\r\n** Subjects must not have received any prior therapy with simvastatin
Subjects must have fully recovered from the acute toxic effects of all prior anti-cancer chemotherapy\r\n* Myelosuppressive chemotherapy: At least  days after the last dose of myelosuppressive chemotherapy ( days if prior nitrosourea) \r\n* Hematopoietic growth factors: At least  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Biologic (anti-neoplastic agent): At least  days after the last dose of a biologic agent; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Cellular therapy: ?  days must have elapsed from last dose of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): ?  days must have elapsed from the last dose of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Antibodies: ?  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade ? \r\n* Palliative radiation therapy (XRT): At least  days after local palliative XRT (small port);  weeks must have elapsed since treatment with therapeutic doses of I-MIBG; at least  days must have elapsed if other substantial BM radiation\r\n* Stem cell infusion without traumatic brain injury (TBI): No evidence of active graft versus (vs.) host disease and at least  days must have elapsed after transplant and  days for autologous stem cell infusion after I-metaiodobenzylguanidine (I-MIBG) therapy\r\n* Prior taxane and nucleoside analogue usage: Patients who have previously received a taxane, including nab-paclitaxel, or a nucleoside analogue, including gemcitabine, are eligible as long as they have not received gemcitabine in combination with nab-paclitaxel\r\n* Medical cannabis and cannabidiol (CBD oil): ?  hours must have elapsed since the last administration of these products\r\n* Investigational agents not otherwise specified: ?  days must have elapsed since the last dose of any agents not specified above; for agents with an uncertain washout period or for any questions or uncertainty the study principle investigator (PI) should be notified
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment; if after the required timeframe, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n* Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive\r\n** >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil count [ANC] counts): >=  days after the last dose of agent\r\n* Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Corticosteroids: If used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n* Hematopoietic growth factors: >=  days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or  days for short-acting growth factor; for growth factors that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n* Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Stem cell Infusions (with or without total body irradiation [TBI]):\r\n** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of graft versus host disease (GVHD)\r\n** Autologous stem cell infusion including boost infusion: >=  days\r\n* Cellular therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.)\r\n* Radiation therapy (XRT)/external beam irradiation including protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial bone marrow (BM) radiation; Note: Radiation may not be delivered to measurable disease tumor site(s) being used to follow response to subprotocol treatment\r\n* Radiopharmaceutical therapy (e.g., radiolabeled antibody, I-MIBG): >=  days after systemically administered radiopharmaceutical therapy\r\n* Patients must not have had prior exposure to tazemetostat or other inhibitor(s) of EZH
Patients must have fully recovered (to grade ) from the acute toxic effects of all prior anti-cancer therapy\r\n* Myelosuppressive chemotherapy: at least  days after the last dose of myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Biologic (anti-neoplastic agent): at least  days after the last dose of a biologic agent; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Immunotherapy: at least  days after the completion of any type of immunotherapy, e.g. tumor vaccines\r\n* Monoclonal antibodies: at least  half-lives of the antibody after the last dose of a monoclonal antibody\r\n* External beam radiation therapy (XRT): at least  days after local palliative XRT (small port); at least  days must have elapsed if prior total body irradiation (TBI) or if >= % radiation of pelvis; >=  days from whole brain radiation, craniospinal radiation, or targeted radiation to central nervous system (CNS) tumors; at least  days must have elapsed if other substantial bone marrow (BM) radiation\r\n* Hematopoietic stem cell transplantation (HSCT): >=  days from stem cell transplant with no evidence of active graft versus (vs) host disease; must be off immunosuppressive therapy for at least  weeks and have no active graft-versus-host disease (GVHD) at the time of entry onto this trial\r\n* Surgery: >=  days from surgery\r\n* Others: >=  days from last dose of short active hematopoietic growth factors, i.e. filgrastim, >=  days for long-acting, i.e. pegfilgrastim\r\n* Steroids: patients with CNS tumors who are managed with steroids are eligible if they have no worsening neurologic deficits and are on a stable or decreasing dose of corticosteroids for greater than or equal to  days prior to registration; patients with leukemia receiving corticosteroids or hydroxyurea are eligible provided that the corticosteroids are not being used to manage GVHD and there has been no increase in corticosteroid of hydroxyurea dose for  days prior to starting PLX
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer chemotherapy\r\n* Myelosuppressive chemotherapy: at least  days after the last dose of myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n* Hematopoietic growth factors: at least  days after the last dose of a long-acting growth factor (e.g. Neulasta) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Biologic (anti-neoplastic agent): at least  days after the last dose of a biologic agent; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Immunotherapy: at least  days after the completion of any type of immunotherapy, e.g. tumor vaccines\r\n* Monoclonal antibodies: at least  half-lives of the antibody after the last dose of a monoclonal antibody\r\n* Radiation therapy (XRT): at least  days after local palliative XRT (small port); at least  days must have elapsed if prior total body irradiation (TBI), craniospinal and/or entire spinal XRT or if >= % radiation of pelvis; at least  days must have elapsed if other substantial bone marrow (BM) radiation\r\n* Stem cell infusion without TBI: no evidence of active graft vs. host disease and at least  days must have elapsed after transplant or stem cell infusion
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer chemotherapy\r\n* Myelosuppressive chemotherapy:\r\n** Solid tumors (Part A and Part B): at least  days after the last dose of myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n** Acute lymphoblastic leukemias (ALL) (Part C):\r\n*** Patients with leukemia who relapse while receiving standard maintenance chemotherapy will not be required to have a waiting period before enrollment onto this study\r\n*** Patients who relapse while they are not receiving standard maintenance therapy, must have fully recovered from all acute toxic effects of prior therapy; at least  days must have elapsed after the completion of cytotoxic therapy, with the exception of hydroxyurea\r\n*** Note: cytoreduction with hydroxyurea can be initiated and continued for up to  hours prior to the start of BMN \r\n*** Note: patients with leukemia are permitted to receive intrathecal chemotherapy, including methotrexate or cytarabine; intrathecal therapy should be restricted to days  and  of each  day cycle \r\n* Hematopoietic growth factors: at least  days after the last dose of a long-acting growth factor (e.g. Neulasta) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Biologic (anti-neoplastic agent): at least  days after the last dose of a biologic agent; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Immunotherapy: at least  days after the completion of any type of immunotherapy, e.g. tumor vaccines\r\n* Monoclonal antibodies: at least  half-lives of the antibody after the last dose of a monoclonal antibody\r\n* Radiation therapy (XRT): at least  days after local palliative XRT (small port); at least  days must have elapsed if other substantial bone marrow (BM) radiation; patients with prior total body irradiation (TBI), craniospinal XRT and/or >= % radiation of the pelvis are not eligible\r\n* Stem cell infusion without TBI: no evidence of active graft vs. host disease and at least  days must have elapsed after transplant or stem cell infusion
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer chemotherapy\r\n* Myelosuppressive chemotherapy:  \r\n** Solid tumors: at least  days after the last dose of myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n** ALCL:\r\n*** Patients with ALCL who relapse while receiving standard maintenance chemotherapy will not be required to have a waiting period before enrollment onto this study\r\n*** Patients who relapse while they are not receiving standard maintenance therapy, must have fully recovered from all acute toxic effects of prior therapy; at least  days must have elapsed after the completion of cytotoxic therapy\r\n* Hematopoietic growth factors: at least  days after the last dose of a long-acting growth factor (e.g. Neulasta) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Biologic (anti-neoplastic agent): at least  days after the last dose of a biologic agent; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Immunotherapy: at least  days after the completion of any type of immunotherapy, e.g. tumor vaccines\r\n* Monoclonal antibodies: at least  half-lives of the antibody after the last dose of a monoclonal antibody\r\n* Radiation therapy (XRT):  \r\n** Solid tumors: at least  days after local palliative XRT (small port); >=  weeks must have elapsed since treatment with therapeutic doses of metaiodobenzylguanidine (MIBG); at least  days must have elapsed if prior total body irradiation (TBI), craniospinal XRT or if >= % radiation of pelvis; at least  days must have elapsed if other substantial bone marrow (BM) radiation\r\n** ALCL: at least  days after local palliative XRT (small port); at least  days must have elapsed if prior TBI, craniospinal XRT or if >= % radiation of pelvis; at least  days must have elapsed if other substantial BM radiation\r\n* Stem cell infusion without TBI: no evidence of active graft vs. host disease and at least  days must have elapsed after transplant and >=  days for autologous stem cell infusion after iodine (I)-MIBG therapy\r\n* Patients must not have received prior therapy with crizotinib\r\n* Prior anthracycline dose: patients with a total lifetime cumulative anthracycline dose of >  mg/m^ at the time of enrollment are not eligible for Part B of the study
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer chemotherapy\r\n* At least  days after the last dose of myelosuppressive chemotherapy ( days if prior nitrosourea); Note: cytoreduction with hydroxyurea can be initiated and continued for up to  hours prior to the start of therapy\r\n* At least  days after the last dose of a long-acting growth factor (e.g. Neulasta) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* At least  days after the last dose of a biologic agent; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* At least  days after the completion of any type of immunotherapy, e.g. tumor vaccines\r\n* At least  half-lives of the antibody after the last dose of a monoclonal antibody\r\n* At least  days after local palliative radiation therapy (XRT) (small port); at least  days must have elapsed if prior total body irradiation (TBI), craniospinal XRT or if >= % radiation of pelvis; at least  days must have elapsed if other substantial bone marrow (BM) radiation\r\n* Patients with prior autologous or allogeneic stem cell transplant (SCT) are excluded from this study\r\n* At least  days must have elapsed since the most recent dose of bleomycin, to allow adequate time to detect evidence of bleomycin-related pulmonary toxicity
Patients must have recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, stem cell transplant or radiotherapy prior to entering this study; all prior treatment-related toxicities must have resolved to =< grade  or meet the inclusion/exclusion criteria prior to enrollment\r\n* Myelosuppressive chemotherapy: \r\n** Must be  days after the last dose of myelosuppressive chemotherapy (excluding hydroxyurea)\r\n** Cytoreduction with hydroxyurea can be initiated and continued for up to  hours prior to the start of therapy\r\n* Intrathecal cytotoxic therapy:\r\n** No waiting period is required for patients having received intrathecal cytarabine, methotrexate, and/or hydrocortisone\r\n** At least  days must have elapsed since receiving liposomal cytarabine (DepoCyte) by intrathecal injection\r\n** Intrathecal cytarabine given at the time of diagnostic lumbar puncture (LP) to evaluate for relapse prior to study enrollment is allowed\r\n* Biologic (anti-neoplastic agent): \r\n** At least  days since the completion of therapy with a biologic agent such retinoids, or DLI (donor lymphocyte infusion without conditioning)\r\n** Note: for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which acute adverse events are known to occur\r\n* Interleukins, Interferons and Cytokines (other than hematopoietic growth factors): \r\n** >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n* Antibodies: \r\n** >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n* Radiation therapy (RT):\r\n** At least  days after local palliative x-ray telescope (XRT) (small port); at least  days must have elapsed if prior traumatic brain injury (TBI), craniospinal XRT or if >= % radiation of pelvis; at least  days must have elapsed if other substantial bone marrow (BM) radiation\r\n* Stem Cell Transplant (SCT) without TBI: \r\n** No evidence of active graft vs. host disease and at least  days must have elapsed after transplant or stem cell infusion\r\n** Patients must be off all systemic immunosuppressive therapy for at least  weeks, excluding hydrocortisone for physiologic cortisol replacement\r\n* Growth factors: \r\n** At least  days after the last dose of a long-acting growth factor (e.g. Neulasta) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair\r\n* Patients must not have received prior exposure to AZD
Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy except organ function; patients must meet the following minimum washout periods prior to enrollment:\r\n* At least  days after the last dose of myelosuppressive chemotherapy ( days for nitrosourea or mitomycin C)\r\n* Radiotherapy:\r\n** At least  days after local palliative radiation therapy (XRT) (small port);\r\n** At least  days must have elapsed after prior total body irradiation (TBI), craniospinal XRT or if > % radiation of pelvis;\r\n** At least  must have elapsed if other substantial bone marrow (BM) radiation;\r\n** At least  days must have passed since last iobenguane (MIBG) or other radionuclide therapy\r\n* At least  days following the last dose of a biologic agent; for agents with known adverse events occurring beyond  days, this duration must be extended beyond the time in which adverse events are known to occur; if extended duration is required, this should be discussed and approved by the study chair\r\n* Monoclonal antibody: At least  days must have elapsed after the last dose of antibody\r\n* At least  days following the last dose of long-acting growth factor (e.g. Neulasta) or  days following short-acting growth factor\r\n* The patient must have no evidence of graft versus host disease and at least  days must have elapsed after transplant, stem cell infusion, or cellular therapy\r\n* At least  weeks from prior major surgical procedure; Note: Biopsy and central line placement/removal are not considered major\r\n* The patient must not have received prior CUDC- therapy; prior treatment with individual PIK or HDAC inhibitors is allowed; patients must not have received therapy with the combination of PIK and HDAC inhibitors
GENERAL INCLUSION CRITERIA FOR SUBPROTOCOLS: At the time of enrollment onto a subprotocol, the following general criteria for initiation of therapy will be required:\r\n* Patients must have fully recovered from the acute toxic effects of all prior anticancer therapy and must meet the following minimum duration from prior anticancer directed therapy prior to enrollment to the subprotocol; if after the required timeframe, the numerical eligibility criteria are met, e.g. blood count criteria, the patient is considered to have recovered adequately\r\n** Cytotoxic chemotherapy or other anticancer agents known to be myelosuppressive: for agents not listed, the duration of this interval must be discussed with the study chair and the study-assigned research coordinator prior to enrollment\r\n*** >=  days after the last dose of cytotoxic or myelosuppressive chemotherapy ( days if prior nitrosourea)\r\n** Anticancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil counts [ANC]): >=  days after the last dose of agent; for agents not listed, the duration of this interval must be discussed with the study chair and the study-assigned research coordinator prior to enrollment\r\n** Antibodies: >=  days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< \r\n** Corticosteroids: If used to modify immune adverse events related to prior therapy, >=  days must have elapsed since last dose of corticosteroid\r\n** Hematopoietic growth factors: >=  days after the last dose of a long-acting growth factor (e.g. Neulasta) or  days for short-acting growth factor; for agents that have known adverse events occurring beyond  days after administration, this period must be extended beyond the time during which adverse events are known to occur; the duration of this interval must be discussed with the study chair and the study-assigned research coordinator\r\n** Interleukins, interferons and cytokines (other than hematopoietic growth factors): >=  days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors)\r\n** Stem cell infusions (with or without TBI):\r\n*** Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >=  days after infusion and no evidence of GVHD\r\n*** Autologous stem cell infusion including boost infusion: >=  days\r\n** Cellular therapy: >=  days after the completion of any type of cellular therapy (e.g. modified T cells, NK cells, dendritic cells, etc.)\r\n** X-ray therapy (XRT)/External Beam Irradiation including Protons: >=  days after local XRT; >=  days after TBI, craniospinal XRT or if radiation to >= % of the pelvis; >=  days if other substantial bone marrow (BM) radiation; note: radiation may not be delivered to measurable disease tumor site(s) being used to follow response to subprotocol treatment\r\n** Radiopharmaceutical therapy (e.g., radiolabeled antibody, I-MIBG): >=  days after systemically administered radiopharmaceutical therapy