Left ventricular ejection fraction (LVEF) below institutional lower limit of normal (LLN) or below %, whichever is lower, as determined by echocardiogram or multi-gated acquisition (MUGA) scan within  weeks of randomization
Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multigated acquisition scan (MUGA) within  days of day  of study
Cardiac ejection fraction (left ventricular ejection fraction [LVEF]) >= institutional lower limit of normal by multi gated acquisition scan (MUGA)/radionuclide ventriculogram (RVG) or echocardiogram (ECHO)
Patients must have a left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (ILLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA) within  days prior to registration
Patients must have an echocardiogram (ECHO) or a nuclear study (multi-gated acquisition scan [MUGA] or first pass) within  weeks ( days) prior to registration to treatment and must not have a left ventricular ejection fraction (LVEF) < institutional lower limit of normal (LLN); if the LLN is not defined at a site, the LVEF must be > % for the patient to be eligible
Left ventricular ejection fraction (LVEF) > lower limit of normal (LLN) based on cardiac echocardiography (ECHO) or multi-gated acquisition (MUGA)
Normal cardiac function, as determined by left ventricular ejection fraction (LVEF) >= institutional lower limit of normal on echocardiogram or multi-gated acquisition scan (MUGA) within  month of registration
Left ventricular ejection fraction (LVEF) >= lower limit of normal (LLN) as assessed by either multigated acquisition (MUGA) scan or echocardiogram (ECHO)
Left ventricular ejection fraction (LVEF) above institutional lower limit of normal (by echocardiogram or multi-gated acquisition [MUGA] scan within  days of registration)
Left ventricular ejection fraction (LVEF) >= lower limit of normal (LLN) by echocardiography (ECHO) or multigated acquisition (MUGA)
Left ventricular ejection fraction (LVEF) >= lower limit of normal (LLN) by echocardiogram (ECHO) or multigated acquisition scan (MUGA)
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multi-gated acquisition (MUGA)
Left ventricular ejection fraction (LVEF) assessment (i.e.,  dimensional [-D] echocardiogram or multi-gated acquisition [MUGA] scan) performed within  weeks prior to study registration indicates an LVEF >= % regardless of the cardiac imaging facilitys lower limit of normal
Baseline (pre-HCT) multi-gated acquisition (MUGA) or echocardiography (ECHO) must demonstrate left ventricular ejection fraction (LVEF) >= the lower limit of normal (LLN) of the institutional normal
Left ventricular ejection fraction (LVEF) >= lower limit of normal (LLN) of the institutional standard of normal as measured by echocardiogram (ECHO) or multiple gated acquisition scan (MUGA) within  weeks prior to first study drug administration
Cardiac function >= international lower limit of normal (ILLN), e.g., left ventricular ejection fraction (LVEF) of > % as assessed by multi gated acquisition scan (MUGA) or echocardiography (ECHO), corrected QT interval (QTc) <  ms
Left ventricular ejection fraction (LVEF) lower limit of normal (LLN) as assessed by either multigated acquisition (MUGA) scan or echocardiogram (ECHO)
Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multigated acquisition scan (MUGA)
Left ventricular ejection fraction (LVEF) >= lower limit of normal (LLN) by echocardiogram (Echo) or multi gated acquisition scan (MUGA)
The left ventricular ejection fraction (LVEF) assessment by -D echocardiogram or multi-gated acquisition (MUGA) scan performed within  days prior to study entry must be greater than or equal to % regardless of the facility's lower limit of normal (LLN).
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA)
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA)
Baseline multi gated acquisition scan (MUGA) or echocardiogram (ECHO) must demonstrate left ventricular ejection fraction (LVEF) >= the lower limit of the institutional normal
Left ventricular ejection fraction (LVEF) > lower limit of normal (LLN) on multi gated acquisition scan (MUGA)
Cardiac ejection fraction (LVEF) by multiple gated acquisition scan (MUGA) less than the institutional lower limit of normal.
Left ventricular ejection fraction (LVEF) >= lower limit of normal (LLN) by echocardiogram (ECHO) or multigated acquisition (MUGA)
Left ventricular ejection fraction (LVEF) >= lower limit of normal (LLN) by echocardiogram (ECHO) or multiple gated acquisition scan (MUGA) within  weeks prior to starting study therapy
Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA)
Left ventricular ejection fraction (LVEF) greater than or equal to institutional/laboratory lower limit of normal (LLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA)
Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (ILLN) (by echocardiogram [ECHO] or multi gated acquisition scan [MUGA])
Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal by cardiac echocardiogram (echo) or multi gated acquisition (MUGA) scan within  days prior to step  registration
CLINICAL/LABORATORY CRITERIA: Patients must have a left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (ILLN) by echocardiography (ECHO) or multi-gated acquisition scan (MUGA) within  days prior to registration
Has a pre-study echocardiogram or multi-gated acquisition (MUGA) scan with an actual left ventricular ejection fraction of greater than or equal to the institutional lower limit of normal within one month of initiating therapy.
Left ventricular ejection fraction (LVEF) below institutional lower limit of normal (LLN) or below %, whichever is lower, as determined by echocardiogram or Multi Gated Acquisition Scan (MUGA) scan
Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal by echocardiogram (ECHO) or multiple gated acquisition scan (MUGA)
Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multigated acquisition scan (MUGA)
Patients must have adequate cardiac function as demonstrated by normal left ventricular ejection fraction (LVEF) >= the lower limit of normal for the facility on multi gated acquisition (MUGA) scan or echocardiogram (ECHO) within  months of enrollment
Patient must have a left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multigated acquisition (MUGA) within  days prior to registration
Left ventricular ejection fraction (LVEF) must be >= the lower limit of normal (LLN) per institutional standards by either echocardiography or radionuclide-based multiple gated acquisition (MUGA)
Left ventricular ejection fraction assessment (echocardiogram or multiple gated acquisition [MUGA] scan) performed within  weeks prior to study initiation, showing a left ventricular ejection fraction (LVEF) value >= lower limit of normal (LLN)
Baseline multi gated acquisition scan (MUGA) or echocardiogram (ECHO) must demonstrate left ventricular ejection fraction (LVEF) >= the lower limit of the institutional normal
History of significant cardiovascular disease, even if currently controlled, or who has signs or symptoms suggesting impaired left ventricular function in the judgment of the investigator must have a screening left ventricular ejection fraction (LVEF) evaluation by echocardiogram (ECHO) or multi gated acquisition scan (MUGA); patients with LVEF measurements below local institutional lower limit of normal or less than % will not be eligible
Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (LLN) AND at least %; LVEF can be assessed by either echocardiogram (ECHO) or multi gated acquisition scan (MUGA)
Left ventricular ejection fraction (LVEF) by echocardiogram or multiple gated acquisition (MUGA) scan ? the lower limit of normal (LLN) for the Institution
Measured cardiac ejection fraction > or = to % or the institutional lower limit of normal by echocardiogram or MUGA scan.
Left ventricular ejection fraction (LVEF) determined by  dimensional echocardiogram (D Echo) or multi-gated acquisition scan (MUGA) ? % or ? local institutional lower limit normal (LLN) whichever is higher.
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multigated acquisition scan (MUGA)
Symptomatic left ventricular dysfunction or baseline left ventricular ejection fraction (LVEF) by multigated acquisition scan (MUGA) or echocardiogram (ECHO) =< % lower limit of institutional normal (LLN)
Screening calculated ejection fraction greater than or equal to the institutional lower limit of normal by multiple gated acquisition (MUGA) scan or by echocardiogram (ECHO); a MUGA is preferred because of greater reproducibility
Baseline multi gated acquisition scan (MUGA) or echocardiogram (ECHO) must demonstrate left ventricular ejection fraction (LVEF) >= the lower limit of the institutional normal
Left ventricular ejection fraction (LVEF) >= lower limit of normal (LLN) as assessed by echocardiography or multigated acquisition (MUGA) scan
Left ventricular ejection fraction (LVEF) results must be >= lower limit of normal (LLN) for institution performing based on results from the multi-gated acquisition (MUGA) or echocardiogram (ECHO) done at baseline
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA)
Subject has left ventricular ejection fraction (LVEF) ? %, or below institution's lower limit of normal (whichever is lower) by echocardiogram (ECHO) or multigated acquisition (MUGA) scan.
Left ventricular ejection fraction >= institutional lower limit of normal by multi-gated acquisition (MUGA) scan or echocardiogram within  days of first protocol treatment
GROUP  (trametinib arm): Left ventricular ejection fraction (LVEF) >= lower limit of normal (LLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA)
Ejection fraction >= lower limit of normal (LLN) by echocardiogram (ECHO) (preferred) or multi gated acquisition scan (MUGA)