History of any cardiac arrhythmias, e.g., ventricular, supraventricular, nodal arrhythmias, or conduction abnormality in the previous months; Left ventricular ejection fraction (LVEF) >= % by echocardiography, multigated acquisition (MUGA), or cardiac magnetic resonance imaging (MRI); no uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities (within days of study registration) Left ventricular ejection fraction (LVEF) >= % by echocardiography or multi-gated acquisition scan (MUGA) or cardiac magnetic resonance imaging (MRI), no uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities Uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiography (EKG) suggestive of acute ischemia or active conduction system abnormalities Left ventricular ejection fraction (LVEF) >= % by echocardiography or multi-gated acquisition scan (MUGA), no uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities Left ventricular ejection fraction (LVEF) >= %, no uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities, within days of study registration (within days for pulmonary and cardiac assessments) Uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiogram (EKG) suggestive of acute ischemia or active conduction system abnormalities Uncontrolled arrhythmias Uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiogram (EKG) suggestive of acute ischemia or active conduction system abnormalities Within days of study registration ( days for pulmonary and cardiac): left ventricular ejection fraction (LVEF) >= % by echocardiography or multigated acquisition (MUGA), no uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities Cardiac function: ejection fraction (EF) >= %, no uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities Patients with uncontrolled angina, severe uncontrolled ventricular arrhythmias, or\n electrocardiographic evidence of acute ischemia or active conduction system\n abnormalities will be excluded Subjects with a known history of severe and/or uncontrolled ventricular arrhythmias. Patients with a known history of severe and/or uncontrolled ventricular arrhythmias History of any cardiac arrhythmias, e.g., ventricular, supraventricular, nodal arrhythmias, or conduction abnormality within months of screening Serious cardiac illness or medical condition including but not confined to: Uncontrolled arrhythmias (e.g. ventricular tachycardia, high-grade atrioventricular (AV)-block, supraventricular arrhythmias which are not adequately rate-controlled); Subjects with a known history of severe and/or uncontrolled ventricular arrhythmias. History of any cardiac arrhythmias, e.g., ventricular, supraventricular, nodal arrhythmias, or conduction abnormality in the previous months. Subjects with a known history of severe and/or uncontrolled ventricular arrhythmias. Ejection fraction (EF) >= % and no uncontrolled angina, symptomatic ventricular arrhythmias, or electrocardiogram (ECG) evidence of active ischemia Ejection fraction (EF) of < %, myocardial infarction (MI) within past months, uncontrolled angina, severe uncontrolled ventricular arrythmias, or ECG evidence of acute ischemia. Abnormal electrocardiogram (EKG): severe uncontrolled ventricular arrhythmias, or evidence of acute ischemia or active conduction system abnormalities; prior to study entry, any EKG abnormality at screening has to be documented by the investigator as not medically relevant Ejection fraction (EF) >= %, no uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities No uncontrolled angina, severe uncontrolled ventricular or arterial arrhythmias, or any evidence of acute ischemia or active conduction system abnormalities (rate controlled atrial fibrillation is not an exclusion) Myocardial infarction, uncontrolled angina, uncontrolled ventricular arrhythmias, or ECG evidence of acute ischemia, within months prior to the Month -Day Visit Myocardial infarction, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia, within months prior to the first dose of study drug Uncontrolled arrhythmias Known history of severe and/or uncontrolled ventricular arrhythmias Evidence of current uncontrolled cardiovascular conditions, including cardiac arrhythmias, congestive heart failure, angina, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Evidence of current uncontrolled cardiovascular conditions, including cardiac arrhythmias, congestive heart failure (CHF), angina, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities Evidence of current, uncontrolled cardiovascular conditions including cardiac arrhythmias, angina, pulmonary hypertension, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Uncontrolled arrhythmias Evidence of current uncontrolled cardiovascular conditions including cardiac arrhythmias, angina, pulmonary hypertension, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities.