Current evidence of cardiac ischemia Grade or higher peripheral ischemia [brief (< hours) episode of ischemia managed non-surgically and without permanent deficit]. Symptomatic peripheral ischemia. Presence of known or suspected ongoing ischemia of non-tumor tissues including Evidence of ischemia or myocardial infarction within the past months, or any significant abnormality on ECG. Electrocardiogram without evidence of acute cardiac ischemia Electrocardiogram without evidence of acute cardiac ischemia within days prior to study registration symptomatic ischemia History of congestive heart failure, symptomatic ischemia, conduction abnormalities uncontrolled by conventional intervention, or myocardial infarction Symptomatic ischemia, or Electrocardiography (EKG) without evidence of ischemia or significant arrhythmia Electrocardiogram without evidence of acute cardiac ischemia <= days prior to randomization. Symptomatic peripheral ischemia Electrocardiography (ECG) without evidence of clinically significant arrhythmia or ischemia. CTEP CTCAE version ., grade or higher peripheral ischemia (brief [< hours (hrs)] episode of ischemia managed non-surgically and without permanent deficit) Symptomatic ischemia or myocardial infarction within the previous mo ECG without evidence of clinically significant arrhythmia or ischemia. ECG without evidence of clinically significant arrhythmia or ischemia History of cerebrovascular or myocardial ischemia within months of initiation Symptomatic peripheral ischemia. Evidence of recent myocardial infarction or ischemia by the findings of S-T elevations of >= mm using the analysis of an electrocardiogram (EKG) performed within days prior to registration No active ischemia by electrocardiography (ECG) or clinical symptoms Grade or higher peripheral ischemia, except for brief (< hrs) episodes of ischemia managed non-surgically and without permanent deficit. ECG evidence of acute ischemia or active conduction system abnormalities with the exception of any of the following: Myocardial infarction within the past months, unstable and/or symptomatic arrhythmia, or evidence of ischemia on ECG. Participants with a recent history (< months) of a major infarct including but not inclusive to bowel ischemia, cerebral vascular accident, transient ischemic attack, myocardial infarction, limb ischemia, or skin necrosis Patients with myocardial ischemia or peripheral muscle ischemia Evidence of recent myocardial infarction or ischemia by the findings of S-T elevations of >= mm using the analysis of an electrocardiogram (EKG) performed within days prior to registration CHF, symptomatic ischemia, conduction abnormalities uncontrolled by conventional intervention, myocardial infarction within m CHF, symptomatic ischemia, conduction abnormalities uncontrolled by conventional intervention, and myocardial infarction within m Patients with myocardial ischemia or peripheral muscle ischemia Patients with myocardial ischemia or peripheral muscle ischemia History of significant tachyarrhythmia, severe angina, or myocardial ischemia History of congestive cardiac failure or an electrocardiography (EKG) suggesting significant conduction defect, or myocardial ischemia, or active psychiatric disease requiring treatment that would interfere with the understanding or conduct of the study Symptomatic ischemia, or Patients with myocardial ischemia or peripheral muscle ischemia