Waldenstroms macroglobulinemia or immunoglobulin M (IgM) myeloma Measurable disease, defined as presence of serum immunoglobulin M (IgM) with a minimum IgM level of > times the upper limit of normal of each institution is required Measurable disease, defined as presence of serum immunoglobulin M (IgM) with a minimum IgM level of > times the upper limit of normal of each institution is required For WM, serum immunoglobulin M (IgM) with a minimum IgM level of ? times the upper limit of normal (ULN). Waldenstroms macroglobulinemia or IgM myeloma Criteria Multiple myeloma of IgM subtype Multiple myeloma with IgM subtype Multiple myeloma with IgM subtype For newly diagnosed multiple myeloma: multiple myeloma of IgM subtype Measurable disease, defined as presence of serum immunoglobulin M (IgM) with a minimum IgM level of >= times the upper limit of normal is required Measurable disease, defined as presence of serum immunoglobulin M (IgM) with a minimum IgM level of > times the upper limit of normal of each institution is required Multiple myeloma of Immunoglobin M (IgM) subtype Patients must have a clinicopathological diagnosis of WM (Owen ), with symptomatic disease meeting criteria for treatment using consensus panel criteria from the Second International Workshop on WM (Kyle ) or serum immunoglobulin M (IgM) > mg/dL, and measurable disease, defined as presence of immunoglobulin M (IgM) paraprotein with a minimum IgM level of > times the upper limit of normal Measurable disease defined as serum monoclonal IgM >. g/dL. Previously untreated patients with lymphoplasmacytic lymphoma (of any subtype: IgG, IgA, IgM) in the asymptomatic phase Must have measurable disease, defined as presence of serum immunoglobulin M (IgM) with a minimum IgM level of ? times the upper limit of each institution's normal value is required. Multiple myeloma of IgM (immunoglobulin M) subtype Multiple Myeloma of IgM subtype. Multiple myeloma of IgM subtype, POEMS, plasma cell leukemia Multiple myeloma of IgM subtype, POEMS, plasma cell leukemia Measurable disease, defined as presence of serum immunoglobulin M (IgM) with a minimum IgM level of > times the upper limit of normal of each institution is required Multiple myeloma with IgM subtype Multiple myeloma with IgM subtype. Immunoglobulin M (IgM) multiple myeloma