Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy prior to registration Patients who have undergone major surgery =< weeks prior to starting study treatment or who have not recovered from side effects of such procedure Patients who have received chemotherapy or any investigational drug < weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone surgery =< weeks or who have not recovered from side effects of this procedure prior to receiving study drug Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from the side-effects of surgery Patients may not have received immunotherapy =< weeks prior to starting the study drug unless patients have recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patient who has undergone major surgery =< weeks prior to starting study treatment or who has not recovered from side effects of such procedure Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such procedure Have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery < weeks of initiation of study medication or who have not recovered from side effects of such procedure Patients who have undergone major surgery < weeks prior to starting study drug. Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Major surgery days or less prior to starting study drug or has not recovered from adverse effects from such procedure. Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such procedure Prior major surgery =< weeks before study drug or not recovered from side effects of such procedure Participants who have undergone major systemic surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study treatment or who have not recovered from side effects of such procedure Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study treatment, who have not recovered from side effects of such procedure Major surgery =< weeks prior to starting a study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to registration or have not recovered from side effects of such procedure are not eligible for participation Participants who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of the surgery Patient who has undergone major surgery =< weeks prior to starting study treatment or who has not recovered from side effects of such procedure Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to registration or who have not recovered from side effects of such procedure are not eligible for participation Participants who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of the surgery Patients who have undergone major surgery =< weeks prior to starting study treatment, who have not recovered from side effects of such procedure Participants who have undergone any major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Participants who have undergone any major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery or radiotherapy ? weeks prior to starting study drug or who have not recovered from side effects of such procedure; Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Have undergone major surgery =< weeks prior to starting BKM or BYL or have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting treatment or who have not recovered from side effects of such therapy Major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such procedure Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Major surgery =< weeks prior to starting a study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such procedure Major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery ? weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone any major surgery within weeks prior to starting study drug or who have not adequately recovered from previous surgery Patients who have undergone major surgery =< weeks prior to starting study drug or who have not recovered from side effects of such procedure