Patients may have had prior adjuvant treatment for pancreatic cancer; the last dose of chemotherapy must have been > months prior to study entry; patients with prior radiotherapy are acceptable; it must be at least months since administration of radiation therapy and all signs of toxicity must have abated Prior use of chemotherapy, radiotherapy, and / or investigational agents for pancreatic cancer Any prior radiotherapy or chemotherapy for pancreatic cancer Previous systemic chemotherapy or radiation for pancreatic cancer is not allowed Had prior systemic therapy for pancreatic cancer No prior therapy for pancreatic cancer, including chemotherapy, radiation therapy, definitive surgery or investigational therapy Any prior therapy (chemotherapy, radiation or surgery) for pancreatic adenocarcinoma other than biliary decompression Prior radiotherapy for pancreatic cancer Prior systemic therapy for pancreatic cancer No prior treatment (chemotherapy, biological therapy, or radiotherapy) for resectable pancreatic cancer A history of previous chemotherapy for pancreatic cancer or abdominal radiation therapy Prior use of radiotherapy or investigational agents for pancreatic cancer Prior radiation therapy for pancreatic cancer Patients must have no history of previous chemotherapy for pancreatic cancer or any abdominal radiation therapy Prior abdominal radiation therapy or prior chemotherapy for pancreatic cancer No prior chemotherapy or radiation for pancreatic cancer Patients who have had any prior therapy for pancreatic cancer Patients must not have received prior surgery, radiation therapy, chemotherapy, targeted therapy, or any investigational therapy for pancreatic cancer Prior chemotherapy or radiation for pancreatic cancer Patients must have had no prior chemotherapy or radiation therapy for pancreatic cancer Prior chemotherapy, targeted therapy, immunotherapy, or any clinical trials or radiotherapy for pancreatic cancer Prior therapy such as chemotherapy or radiation therapy or anti-tumor experimental therapy for pancreatic cancer Prior therapy with ? systemic chemotherapy regimen for unresectable or metastatic pancreatic cancer or unwilling/unable to receive systemic chemotherapy Prior treatment with chemotherapy or radiation for pancreatic cancer or prior treatment with radiation for other diagnoses to expected pancreatic cancer treatment fields. Prior treatment with any chemotherapy for metastatic disease from pancreatic cancer Any prior chemotherapy, targeted/biologic therapy, or radiation for treatment of the patient's pancreatic tumor Any prior chemotherapy or radiation for treatment of the patients pancreatic tumor Part B only: Prior therapy (including investigational agents) for pancreatic cancer Prior treatment with chemotherapy or radiation for pancreatic cancer or prior treatment with radiation for other diagnoses to expected pancreatic cancer treatment fields. Any prior treatment (chemotherapy, radiation) for pancreatic cancer Patient must not have received prior chemotherapy or radiation for pancreatic cancer Patient must not have received prior chemotherapy or radiation for pancreatic cancer and no exposure to systemic chemotherapy Prior chemotherapy, immunotherapy or radiation for pancreatic cancer Any prior radiotherapy, chemotherapy, surgery, or investigational therapy for adjuvant or metastatic pancreatic cancer Any prior chemotherapy or radiation for treatment of the patients pancreatic tumor Any prior systemic or investigational therapy for pancreatic cancer