All patients must have undergone complete hysterectomy and bilateral salpingo-oophorectomy at the time of original therapy for their uterine carcinoma Non-childbearing potential (i.e., physiologically incapable of becoming pregnant), including any female who has had: \r\n* A hysterectomy \r\n* A bilateral oophorectomy (ovariectomy) \r\n* A bilateral tubal ligation \r\n* Is post-menopausal Permanent sterilization (hysterectomy and/or bilateral oophorectomy, or bilateral tubal ligation with surgery, or vasectomy) at least months prior to Screening Surgically sterile defined as a bilateral tubal ligation at least months prior to administration of study drug, bilateral oophorectomy, or complete hysterectomy, OR Pregnant, nursing, or of childbearing potential and refuse hysterectomy or bilateral salpingo-oophorectomy Prior bilateral oophorectomy; Documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy, or bilateral salpingectomy, but not by tubal ligation. For women of child-bearing potential, agreement to use adequate birth control (abstinence, hysterectomy, bilateral oophorectomy, bilateral tubal ligation, oral contraception, IUD, or use of condoms or diaphragms) Female subjects must be either:\r\n* Postmenopausal; defined as age > years with no menses for or more months without an alternative medical cause OR\r\n* Permanently surgically sterile (bilateral oophorectomy, bilateral salpingectomy or hysterectomy) Documentation of irreversible surgical sterilisation by hysterectomy, bilateral oophorectomy, or bilateral salpingectomy, but not tubal ligation. Permanently surgical sterile (bilateral oophorectomy, bilateral salpingectomy or hysterectomy); or Has undergone a previous hysterectomy defined as removal of the entire uterus or will have a hysterectomy as part of their initial cervical cancer therapy. NOTE: Women who have had a partial/subtotal hysterectomy are eligible to participate in the study Permanently surgical sterile (bilateral oophorectomy, bilateral salpingectomy or hysterectomy); or Note: WoCBP are any women between menarche and menopause who have not been permanently sterilized, capable of procreation. Permanent sterilization includes hysterectomy and/or bilateral oophorectomy and/or bilateral salpingectomy but excludes bilateral tubal ligation/occlusion. Postmenopause is defined as: Bilateral oophorectomy; Age ? ; Age < and amenorrheic for ? months in the absence of an alternative medical cause and FSH and estradiol in postmenopausal ranges. Documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy, or bilateral salpingectomy All patients must be surgical candidates for complete hysterectomy and bilateral salpingo-oophorectomy and pelvic and aortic lymphadenectomy For women of child-bearing potential, agreement to use adequate birth control (abstinence, hysterectomy, bilateral oophorectomy, bilateral tubal ligation, oral contraception, IUD, or use of condoms or diaphragms) A female is eligible to enter and participate in this study if she is of:\r\n* Non-childbearing potential (i.e., physiologically incapable of becoming pregnant), including any female who has had:\r\n** A hysterectomy\r\n** A bilateral oophorectomy (ovariectomy)\r\n** A bilateral tubal ligation\r\n** Is post-menopausal Surgical staging to include total abdominal hysterectomy, bilateral salpingo-oophorectomy, peritoneal washings, and lymph node samplings Surgical staging to include total abdominal hysterectomy, bilateral salpingo-oophorectomy, peritoneal washings, and lymph node samplings as per standard Gynecologic Oncology Group (GOG) criteria documented surgically sterile (e.g., hysterectomy, bilateral salpingectomy, bilateral oophorectomy) Surgically sterile defined as bilateral tubal ligation or bilateral oophorectomy or hysterectomy In order to be considered as sterilized or infertile, a patient must have undergone surgical sterilization (vasectomy/bilateral tubectomy; hysterectomy and bilateral ovariectomy) or be postmenopausal ( months or more with no period prior to enrolment). Prior hysterectomy Prior bilateral oophorectomy or Patients must have undergone a hysterectomy (total abdominal hysterectomy, vaginal hysterectomy or radical hysterectomy, or total laparoscopic hysterectomy) for carcinoma of the cervix or endometrium within days prior to registration; performance of a bilateral salpingo-oophorectomy will be at the treating surgeons discretion Patients who have undergone a previous hysterectomy or will have a hysterectomy as part of their initial cervical cancer therapy; this includes patients with a prior history of supracervical hysterectomy has not undergone a hysterectomy or bilateral oophorectomy or Post hysterectomy, bilateral oophorectomy, bilateral salpingectomy or bilateral tubal ligation at least weeks prior to screening. Documented hysterectomy or oophorectomy must be confirmed with medical records of the actual procedure or confirmed by ultrasound. Tubal ligation must be confirmed with medical records of the actual procedure otherwise the subject must be willing to use two adequate barrier methods throughout the study, starting with the screening visit through days after the last dose of study therapy. Information must be captured appropriately within the site's source documents Age ? with prior bilateral oophorectomy Prior bilateral oophorectomy Postmenopausal women defined by at least one of the following criteria:\r\n* Prior bilateral oophorectomy OR amenorrheic for >= months (if =< years of age and prior to chemotherapy, or on medical ovarian ablative therapy\r\n* Previous hysterectomy with one or both ovaries left in place (previous hysterectomy in which documentation of bilateral oophorectomy is unavailable AND FSH values consistent with the institutional normal values for the post-menopausal state; FSH levels must be obtained within days prior to registration) Has experienced menarche and has not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy); and Permanently surgical sterile (bilateral oophorectomy, bilateral salpingectomy or hysterectomy). Prior bilateral oophorectomy Patients who have had a simple hysterectomy (cut through hysterectomy) Endometrial cancer patients must have underwent surgical treatment (total abdominal hysterectomy/bilateral salpingo oophorectomy [TAH/BSO]) and radiation therapy (EBRT or IVRT) All patients must be surgical candidates for complete hysterectomy and bilateral salpingo-oophorectomy and pelvic and aortic lymphadenectomy Prior hysterectomy Documented surgically sterile (e.g., hysterectomy, bilateral salpingectomy, bilateral oophorectomy) Or, if of childbearing potential, Patients must have a hysterectomy and bilateral oophorectomy prior to initiation of therapy. Surgical sterilization (hysterectomy and/or bilateral oophorectomy) or tubal ligation at least six weeks before start of study treatment. Documented oophorectomy or hysterectomy Have a negative pregnancy test for females at screening, preferably done within week before day of treatment (not applicable to patients with bilateral oophorectomy and/or hysterectomy) Women must be postmenopausal (> months without menses) or surgically sterile (ie, by hysterectomy and/or bilateral oophorectomy) or must be using effective contraception A female is eligible to enter and participate in this study if she is of non-childbearing potential (i.e., physiologically incapable of becoming pregnant), including any female who has had:\r\n* A hysterectomy\r\n* A bilateral oophorectomy (ovariectomy)\r\n* A bilateral tubal ligation\r\n* Is post-menopausal Patients must not have had a prior hysterectomy, bilateral oophorectomy or sterilization of any method History of hysterectomy, bilateral oophorectomy or ovarian irradiation Patients must be post-menopausal, as defined by at least one of the following:\r\n* >= months since the last menstrual period OR\r\n* Prior bilateral oophorectomy OR\r\n* Previous hysterectomy with one or both ovaries left in place (or previous hysterectomy in which documentation of bilateral oophorectomy is unavailable) AND (unless >= years of age) follicle-stimulating hormone (FSH) values consistent with the institutional normal values for the postmenopausal state Patients must be postmenopausal, as defined by at least one of the following:\r\n* >= months since the last menstrual period OR\r\n* Prior bilateral oophorectomy OR\r\n* Current use of a GnRH agonist OR\r\n* Previous hysterectomy with one or both ovaries left in place (or previous hysterectomy in which documentation of bilateral oophorectomy is unavailable) AND FSH values consistent with the institutional normal values for the postmenopausal state; if patient is under the age of , FSH levels must be obtained within days prior to registration Prior bilateral tubal ligation or hysterectomy (as this would prevent chromopertubation) Without hysterectomy Report having had a hysterectomy Have had hysterectomy Prior hysterectomy For women of child-bearing potential, agreement to use adequate birth control (abstinence, hysterectomy, bilateral oophorectomy, bilateral tubal ligation, oral contraception, IUD, or use of condoms or diaphragms) months without a period/menstrual cycle or having had a bilateral oophorectomy. Prior hysterectomy with removal of the cervix Women who have undergone a hysterectomy with removal of the cervix Participants must be scheduled for risk-reducing salpingo-oophorectomy with or without hysterectomy either bilateral or unilateral (if prior unilateral oophorectomy or salpingectomy for benign condition) Postmenopausal women\r\n* Amenorrhea for at least months (preceding the time of registration), or\r\n* History of hysterectomy and bilateral salpingo-oophorectomy, or\r\n* At least years of age with prior hysterectomy with or without oophorectomy, or \r\n* Age to with a prior hysterectomy without oophorectomy or with a status of ovaries unknown with documented follicle-stimulating hormone level demonstrating elevation in postmenopausal range Surgical menopause with bilateral oophorectomy GYNECOLOGIC CANCER: Scheduled to undergo a hysterectomy and/or salpingo-oophorectomy Prior bilateral salpingo-oophorectomy obtaining surgical history (e.g., tubal ligation or hysterectomy) Women who are planning to undergo hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy for the management of their endometrial cancer Hysterectomy. Prior bilateral surgical oophorectomy, or