Post-prostatectomy patients with a detectable serum PSA (>= ., but =< . ng/mL) at study entry (within  days of Step  registration) and at least one of the following:\r\n* Gleason score - (International Society of Urological Pathology [ISUP] grade group  to )\r\n* ISUP grade group:\r\n** Grade group ?=?Gleason score?=<?, \r\n** Grade group ?=?Gleason score ?+??=?,\r\n** Grade group ?=?Gleason score ?+??=?, \r\n** Grade group ?=?Gleason score , \r\n** Grade group ?=?Gleason scores  and \r\n* >= Ta disease\r\n* Persistent elevation of PSA after prostatectomy measured within  days after surgery (PSA never became undetectable) of > . but < . ng/mL (PSA nadir)
Histological evaluation of prostate biopsy with assignment of a Gleason score to the biopsy material;Gleason score must be in the range of -. >  cores are strongly recommended.
Gleason score, obtained at biopsy, =< ,  +  = , or  +  = 
Gleason Score ? ; and  or less positive lesions on prior MR US fusion guided prostate biopsy.
Gleason score =<  (neither architectural pattern =< )
Histological evaluation of prostate biopsy with assignment of a Gleason score to the biopsy material; Gleason score must be in the range of -. >  cores are strongly recommended.
Cohort A (M)\r\n* Clinically localized disease with a minimum of  or more cores involved with cancer on diagnostic biopsy (if T by magnetic resonance imaging [MRI] can have <  positive cores), or <  positive cores if there is >  cm tumor on prostate MRI:\r\n** With Gleason score    Or\r\n** Gleason + with one of the following features:\r\n*** PSA >=  ng/mL within  months prior to diagnostic biopsy\r\n*** MRI suspicious for radiographic T disease; defined as > % probability of extracapsular extension or seminal vesicle invasion in the opinion of the reading radiologist Or\r\n** Gleason + or + and Oncotype DX genomic prostate score of > \r\n* With or without clinical N (size > .cm in the short axis) OR
Patients with concomitant Gleason score + prostate cancer in less than % of any core at any site will be considered eligible.
Prostate biopsy with Gleason score and TNM staging within  days prior to registration
For confirmation of high risk local failure status, patients will have any one of the following:\r\n* Computed tomography (CT) or magnetic resonance imaging (MRI) demonstrating seminal vesicle invasion (SVI) or extraprostatic extension (EPE) within  year of enrollment into the study\r\n* Pre-biopsy prostate-specific antigen (PSA) >= \r\n* Gleason score - (Gleason  must be +), presence of any Gleason  (even if a tertiary score) as determined at diagnostic biopsy\r\n* Gleason score  and > % of biopsy cores positive for prostate cancer\r\n* Clinical stage >= T (staging by imaging acceptable)
Cohort B  Prostate cancer (Gleason  or less); must have histological proof of Gleason =<  with no evidence of metastatic disease (patient with any degree of extra-prostatic capsule extension are not eligible
Biopsy positive for adenocarcinoma of the prostate containing any quantity of Gleason  component (e.g. Gleason score +, +, +)
Gleason score =< , no tertiary pattern >= 
Gleason score -
Patient must have a histological evaluation of the prostate biopsy with assignment of a Gleason score to the biopsy material; Gleason scores =<  (+)
Histological evaluation of prostate biopsy with assignment of a Gleason score to the biopsy material demonstrating Gleason score - within  days of registration
Histological evaluation of prostate biopsy with assignment of a Gleason score to the biopsy material; Gleason score must be in the range of -; (the highest Gleason score in any core reported on the pathology report will be used for determining inclusion)
Gleason score  or higher
Gleason score of + or lower
Gleason (+) or higher score
Subjects with untreated organ confined prostate cancer (clinical stage =< Tb, Gleason =<  +  with no more than a % component of Gleason )
Any significant cancer outside of MRI target (ROI) area, defined as Gleason score >=  + 
Any Gleason score >  +  or Gleason score  +  with the secondary pattern exceeding %
Gleason score  (+) and
Gleason score ?  + 
Gleason  or higher score
Gleason score ;
Gleason score > 
Gleason score  or  (no  grades), based on TRUS guided Transperineal Mapping Biopsy, as defined in the protocol.
The Gleason score should be less than or equal to 
Gleason score sum of less than or equal to 
For men =<  years, biopsy Gleason score =< ; for men >  years, biopsy Gleason score =< ( + ) = 
Gleason score on diagnostic biopsy specimens of >= 
Primary diagnosis of untreated with clinically localized prostate cancer with Gleason score of , , or 
Gleason score equal to or less than 
Has no Gleason grade  or ,
Gleason score of  - 
Localized prostate cancer with Gleason score >= 
As per medical record, early stage prostate cancer (pathologic stage - with Gleason score =< ; or pathologic stage  with Gleason score =< )
>=  core prostate biopsy completed prior to randomization with at least  mm of tumor and Gleason sum =<  with no pattern  or Gleason + in < % of all cores; AND residual tumor tissue from such biopsy is obtainable and donated for the research
Gleason grade + or less
Gleason score  ( +  or  + ), based on mapping prostate biopsy, with no more than mm cancer in maximal linear dimension in any single core.
Single hemilateral index Gleason  lesion, identified in the prostate based on biopsy mapping with supporting MRI; may have secondary Gleason  lesion on ipsilateral or contralateral side confirmed with biopsy and/or MRI.
Gleason  tumors must be MRI visible:
Patient is at low risk for metastasis with Gleason score at diagnosis < .
Gleason score of >=  (+)
Greater than  cores positive, of any Gleason score, on the University of Miami (UM) review
Greater than  cores positive for Gleason + cancer
Gleason + or higher cancer in any single biopsy core
Gleason =< +
No tertiary Gleason grade >= 
PRE-ENROLLMENT BIOPSY PARAMETERS: Gleason  (+) or  (+)
FINAL ENROLLMENT BIOPSY PARAMETERS: Gleason  (+) or  (+)
Gleason score =< 
Histologically confirmed adenocarcinoma of the prostate gland by needle core samples with assigned Gleason score
Gleason score (GS): -
Gleason score (GS) +=