Participants may not have a dependency on IV hydration or total parenteral nutrition (TPN)
Participant may not have a percutaneous endoscopic gastrostomy (PEG) tube or be receiving total parenteral nutrition (TPN)
Patient has an inability to swallow oral medications; Note: patient may not have a percutaneous endoscopic gastrostomy (PEG) tube or be receiving total parenteral nutrition (TPN)
Current dependency on intravenous (IV) hydration or total parenteral nutrition (TPN)
Patients requiring IV hydration or parenteral nutrition
Patients may not have current dependency on intravenous (IV) hydration or total parenteral nutrition (TPN)
Dependency on IV hydration or total parenteral nutrition (TPN)
Current dependency on total parenteral nutrition or IV fluid hydration.
PHASE I STUDY ELIGIBILITY CRITERIA:\r\nCurrent dependency on total parenteral nutrition (TPN) or IV fluid hydration
PHASE II COLORECTAL CANCER COHORT  (MEDI+C ONLY):\r\nCurrent dependency on total parenteral nutrition (TPN) or IV fluid hydration
Dependency on intravenous (IV) hydration or total parenteral nutrition (TPN)
Ongoing use of total parental nutrition
Patient has an inability to swallow oral medications; Note: Patient may not have a percutaneous endoscopic gastrostomy (PEG) tube or be receiving total parenteral nutrition (TPN)
Patient has an inability to swallow oral medications and patients with gastrointestinal disorders likely to interfere with absorption of the study medication. Note: Patient may not have a percutaneous endoscopic gastrostomy (PEG) tube or be receiving total parenteral nutrition (TPN).
Dependency on IV hydration or total parenteral nutrition (TPN)
No current dependency on intravenous (IV) hydration or total parental nutrition (TPN)
Current dependency on IV hydration or total parenteral nutrition (TPN)
Participants may not have a dependency on intravenous (IV) hydration or total parenteral nutrition (TPN)
Uncontrolled infection or significant co-morbidity (e.g., uncontrolled diabetes, severe diarrhea that requires total parenteral nutrition [TPN])
Current dependency on intravenous (IV) hydration or total parenteral nutrition (TPN)
patients requiring total parenteral nutrition
Severe diarrhea (? grade ) not controllable with medication or that requires total parenteral nutrition
Patient is currently receiving or planned to receive concurrent total parenteral nutrition and/or metoclopramide
Patients who are not fed orally (gastrostomy [G]-tube dependent, total parenteral nutrition [TPN]-dependent)
Need of total parenteral nutrition
Ongoing parenteral nutrition (receiving intravenous nutrition support at the time of enrollment); note: patients may be receiving maintenance intravenous (IV) fluids