No active known autoimmune disease, including colitis, inflammatory bowel disease (i.e. ulcerative colitis or Crohns disease), rheumatoid arthritis, panhypopituitarism, adrenal insufficiency Inflammatory bowel disease that is uncontrolled or on active treatment (Crohns disease, ulcerative colitis) . Active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis); Active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis). Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis), or any other chronic, serious GI condition associated with diarrhea; NOTE: Subjects with known diverticulosis are permitted to enroll Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g. Crohns disease, ulcerative colitis). Has active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) or pneumonitis Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis). Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis) Has active or prior documented inflammatory bowel disease (eg, Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g. Crohns disease, ulcerative colitis) or a history of primary immunodeficiency Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Inflammatory bowel disease that is uncontrolled or on active treatment (Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Patients with a history of inflammatory bowel disease such as Crohns disease and ulcerative colitis Patients with a history of inflammatory bowel disease such as Crohns disease and ulcerative colitis PHASE I STUDY ELIGIBILITY CRITERIA:\r\nActive or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis); eligibility for patients with asymptomatic and a previous diagnosis of immune or inflammatory colitis, or patients with chronic diarrhea > month without immune or inflammatory colitis is a PI decision on an individual patient basis PHASE II STUDY METASTATIC CASTRATE-RESISTANT PROSTATE CANCER COHORT ELIGIBILITY CRITERIA (MEDI+O ONLY):\r\nActive or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis); eligibility for patients with asymptomatic and a previous diagnosis of immune or inflammatory colitis, or patients with chronic diarrhea > month without immune or inflammatory colitis is a PI decision on an individual patient basis PHASE II COLORECTAL CANCER COHORT (MEDI+C ONLY):\r\nActive or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis); eligibility for patients with asymptomatic and a previous diagnosis of immune or inflammatory colitis, or patients with chronic diarrhea > month without immune or inflammatory colitis is a PI decision on an individual patient basis History of collagen vascular disease or inflammatory bowel disease (Crohns or ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, irritable bowel syndrome, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis). Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g. Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Patients must not have a documented history of inflammatory bowel disease (including ulcerative colitis and Crohns disease) or diverticulitis (history of diverticulosis is allowed) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Inflammatory bowel disease (Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Patients with a history of Inflammatory bowel disease such as Crohns disease and ulcerative colitis Active or prior documented inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis) History of inflammatory bowel disease (e.g., Crohns, ulcerative colitis) - note patients with irritable bowel syndrome are eligible Active or prior documented inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis). Active or prior documented inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis) Inflammatory bowel disease (Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (eg, Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g., Crohns disease, ulcerative colitis) Active or prior documented inflammatory bowel disease (e.g. Crohns disease, ulcerative colitis) Inflammatory bowel disease (e.g. Crohns disease, ulcerative colitis) Participants with inflammatory bowel disease (e.g., ulcerative colitis, Crohns) Patients with a diagnosis of inflammatory bowel disease, i.e. Crohns disease or ulcerative colitis Prior diagnosis of cancer (except non-melanoma skin cancer), Crohns disease, inflammatory bowel disease or colitis Inflammatory bowel disease (Crohns disease, ulcerative colitis)