Enrolled on SJMB and completed protocol directed radiation therapy EXPANDED ACCESS COHORT: Participants must be currently enrolled to DFCI protocol number - or discontinued from protocol - solely because the study agents were no longer available via protocol - Subjects must be co-enrolled in protocol -C- Subjects must be co-enrolled in -C- Subjects must be co-enrolled in protocol -C- Subjects must be co-enrolled in protocol -C- Subjects must be co-enrolled in protocol -C- Subjects must be co-enrolled in protocol -C- Subjects must be co-enrolled on protocol -C- Subjects must be co-enrolled in protocol -C- Currently enrolled in another investigational therapy protocol for AML. Subjects must be co-enrolled in protocol -C- Subjects must be co-enrolled in protocol -C- Enrolled in another treatment protocol Subjects must be co-enrolled in protocol -C- Subjects must be co-enrolled in protocol -C- Subject must be co-enrolled in protocol -C- Subjects must be co-enrolled on protocol -C- Male or female subjects of the age defined in the original protocol they were enrolled. Be currently enrolled in another investigational treatment protocol Subjects will not be treated with any radiation, chemotherapy, or investigational agents while enrolled in this protocol. Be currently enrolled in another investigational protocol The subject must have received tivozanib while enrolled in another protocol, must be tolerating study drug and must currently display clinical benefit. The length of time that a subject must be on the parent protocol before rolling over to this protocol will be dictated by the parent protocol. Participants enrolled in a radiation de-intensification protocol Previously enrolled patients who completed this protocol Patient is not enrolled on an investigational nonmyeloablative HCT protocol, in which case protocol serves as an independent primary treatment protocol and the patient must meet the following inclusion and exclusion criteria: Subject enrolled into the protocol BDS-USHPV and identified as eligible for the longitudinal protocol Subjects enrolled into protocol BDS-USHPV with a baseline colposcopy and biopsy procedure and not treated. Patient must be enrolled or being considered for enrollment on protocol -