Leukemia with active central nervous system (CNS) involvement Active central nervous system (CNS) involvement by leukemia Evidence of leukemic meningitis or other central nervous system (CNS) involvement by leukemia Have active central nervous system (CNS) leukemia Participants with known central nervous system (CNS) leukemia involvement should be excluded from this clinical trial; patients with a history of CNS leukemia that has been treated and is no longer active as judged by the treating investigator are eligible Active central nervous system (CNS) leukemia Active central nervous system (CNS) involvement with leukemia Active, uncontrolled central nervous system (CNS) disease including CNS leukemia Presence of active untreated central nervous system (CNS) leukemia Active, uncontrolled central nervous system (CNS) leukemia involvement Patients with active central nervous system (CNS) leukemia eligible at the discretion of treating physician Active central nervous system (CNS) or testicular involvement by leukemia Patients with active, uncontrolled central nervous system (CNS) leukemia will not be eligible Active central nervous system (CNS) leukemia at time of treatment Patients with current evidence of active central nervous system (CNS) leukemia If prior central nervous system (CNS) leukemia, it must be treated and in CNS CR Symptomatic and refractory central nervous system (CNS) leukemia Active leukemia in the central nervous system (CNS) Patients must not have active central nervous system leukemia; patients with history of central nervous system (CNS) leukemia with no evidence of active CNS disease may be enrolled; maintenance intrathecal chemotherapy for adequately treated CNS involvement with leukemia is allowed with approval from the study supporter History of plasma cell leukemia or MM central nervous system (CNS) involvement Active and/or untreated central nervous system (CNS) leukemia Clinical evidence of active central nervous system (CNS) leukemia requiring active therapy; prior CNS leukemia well-controlled by ongoing therapy is allowed Active central nervous system (CNS) leukemia No evidence of extramedullary leukemia, such as central nervous system (CNS) or soft tissue involvement Presence of leukemia in the central nervous system (CNS) Have active central nervous system (CNS) leukemia Presence of leukemia in the central nervous system (CNS) Active central nervous system (CNS) leukemia at time of HCT Evidence of active extramedullary disease (including central nervous system [CNS] leukemia) Active central nervous system (CNS) leukemia at time of HSCT Clinical symptoms suggesting active central nervous system (CNS) leukemia or known CNS leukemia Has central nervous system (CNS) involvement of leukemia or a history of CNS leukemia History of plasma cell leukemia or central nervous system (CNS) involvement Have clinical symptoms suggestive of active central nervous system (CNS) leukemia or known CNS leukemia. Subjects must not have evidence of active leukemia in the central nervous system (CNS) Active central nervous system (CNS) leukemia Active or suspicion of central nervous system (CNS) leukemia Proven Central Nervous System (CNS) leukemia Evidence of active central nervous system (CNS) leukemia Patients with active/uncontrolled central nervous system (CNS) leukemia Active central nervous system (CNS) leukemia or known CNS leukemia. No active extramedullary leukemia or known active central nervous system (CNS) involvement by malignancy; such disease treated into remission is permitted Central nervous system (CNS) leukemia Active central nervous system (CNS) involvement with leukemia Any past or current Central Nervous System (CNS) involvement, including leptomeningeal leukemia. Clinical evidence of active central nervous system (CNS) leukemia Subjects with clinical symptoms suggesting active central nervous system (CNS) leukemia or known CNS leukemia. Active central nervous system (CNS) leukemia Presence of leukemia in the central nervous system (CNS) Patients with active and/or untreated central nervous system (CNS) leukemia will not be eligible Active or prior central nervous system (CNS) leukemia, unless in complete remission for at least months Active central nervous system (CNS) leukemia at time of treatment Active central nervous system (CNS) leukemia Active, symptomatic central nervous system (CNS) leukemia; Active central nervous system (CNS) leukemia Presence of central nervous system (CNS) leukemia. If prior central nervous system (CNS) leukemia, it must be treated and in CNS complete remission (CR) Current evidence of central nervous system (CNS) leukemia For participants with leukemia, has overt central nervous system (CNS) disease (CNS status). If prior central nervous system (CNS) leukemia, it must be treated and have no evidence of CNS disease No active extramedullary leukemia or known active central nervous system (CNS) involvement by malignancy; such disease treated into remission is permitted No active extramedullary leukemia or known active central nervous system (CNS) involvement by malignancy; such disease treated into remission is permitted Active central nervous system (CNS) leukemia Clinical evidence of central nervous system (CNS) or pulmonary leukostasis, or CNS leukemia Clinical suspicion of active central nervous system (CNS) involvement by leukemia Has presence of central nervous system (CNS) involvement of leukemia or a history of CNS leukemia Patients with active central nervous system leukemia are excluded from this clinical trial; patients with a history of central nervous system (CNS) leukemia but no active disease at the time of enrollment are eligible; the absence of CNS disease must be confirmed by flow cytometric and cytologic examination of the cerebrospinal fluid (CSF) within days of study enrollment