Concomitant administration of any proton pump inhibitor (PPI) is not permitted during the study; patients receiving PPI therapy before enrollment must stop using the PPI for  days before their first dose of study drugs
Chronic concomitant treatment with proton pump inhibitors must discontinue the drug for  days prior to registration on the study
Patients CANNOT have daily or chronic use of a proton pump inhibitor (PPI) and/or having taken a PPI within  days before receiving the first dose of study drug
Patients must not be receiving any proton pump inhibitors at the time of registration
Participants receiving any medications or substances that are moderate or strong inhibitors or inducers of CYPA within  days of registration; proton pump inhibitors (PPI) may be taken while on study, however it is recommended that the PPI is taken  hours from the time of palbociclib administration; if needed, alternative antacid therapies may be used including H-receptor antagonists and locally acting antacids; H-receptor antagonists should be administered with a staggered dosing regimen (twice daily); the dosing of palbociclib should occur at least  hours after H-receptor antagonist evening dose and  hours before the H-receptor antagonist morning dose
Subjects requiring daily or chronic use of a proton pump inhibitor (PPI) and/or having taken a PPI within  days prior to study registration
Daily or chronic use of a proton pump inhibitor (PPI) and/or having taken a PPI within  days before receiving the first dose of the study drugs.
Patients receiving proton pump inhibitors (PPI) which cannot be discontinued  days prior to the start study treatment and for the duration of the study.
Patients receiving proton pump inhibitors which cannot be discontinued  days prior to the start study treatment and for the duration of the study.
Daily or chronic use of a proton pump inhibitor (PPI) and/or having taken a PPI within  days before receiving the first dose of study drug.
Concomitant administration of any proton pump inhibitor (PPI) is not permitted during the study; patients receiving PPI therapy before enrollment must stop using the PPI for  days before their first dose of study drugs
Participants who are taking proton pump inhibitors (PPIs) within  days of the first dose of study drug or who require treatment with PPIs throughout the trial or those who are taking H receptor antagonists within  hours of the first dose of study drug.
Daily or chronic use of a proton pump inhibitor (PPI) and/or having taken a PPI within  days before receiving the first dose of study drug
Patients who are taking proton pump inhibitor (PPI) within  days before receiving the first dose of study drug or who require treatment with PPIs throughout the trial or those who are taking H receptor antagonists within  hours of the first dose of study drug
Patients receiving proton pump inhibitors (PPI) which cannot be discontinued  days prior to the start study treatment and for the duration of the study.
Daily or chronic use of a proton pump inhibitor (PPI) and/or having taken a PPI within  days before receiving the first dose of study drug
Daily or chronic use of a proton pump inhibitor (PPI) and/or having taken a PPI within  days before receiving the first dose of study drug
Daily or chronic use of a proton pump inhibitor (PPI) and/or having taken a PPI within  days before receiving the first dose of study drug
Subjects currently receiving H-blocker or proton pump inhibitors (or unable to stop at least  days prior to the first treatment).
Daily or chronic use of a proton pump inhibitor (PPI) and/or having taken a PPI within  days before receiving the first dose of study drug
Patients who are taking proton pump inhibitor (PPI) within  days before receiving the first dose of study drug or who require treatment with PPIs throughout the trial or those who are taking H receptor antagonists within  hours of the first dose of study drug
Treatment with proton pump inhibitors (PPIs) within  days prior to enrollment.
Treatment with an H blocker, other than famotidine; if the subject requires a proton pump inhibitor (PPI), then esomeprazole, pantoprazole, or rabeprazole may be given
Patient with documented treatment failure of his/her handicap(s) with at least one of the following therapy used at optimized dose: Anti H, Anti H, Proton pump inhibitor, Osteoclast inhibitor, Cromoglycate Sodium, Antileukotriene
Subjects must be willing and able to come off any proton pump inhibitor (PPI)/other strong cytochrome P family  subfamily A member  (CYPA) inhibitors or inducers/simvastatin
Treatment with proton pump inhibitors within  days prior to study entry
Participants requiring daily or chronic use of a proton pump inhibitor (PPI) and/or having taken a PPI within  days before receiving the first dose of study drug.
Proton pump inhibitors
Current or anticipated need for treatment with proton pump inhibitors (PPI); patients on proton pump inhibitors who can be switched to histamine receptor H (H)-blockers before the start of the study are still eligible
Patients who are taking proton pump inhibitors within  days of the first dose or who require treatment with proton pump inhibitors during the trial or those who are taking H receptor antagonists within  hours of the first dose
Treatment with proton pump inhibitor (PPI); patients on PPI therapy prior to enrollment must stop using the PPI for at least  days prior to the first dose of MLN
Has taken proton pump inhibitors within  days before the first administration of study drug.
Receiving treatment with long acting proton pump inhibitors, and cannot be discontinued  days prior to the start of INC treatment and during the course of the study.
Concomitant administration of any proton pump inhibitor (PPI) is not permitted during the study; patients receiving PPI therapy before enrollment must stop using the PPI for  days before their first dose of study drugs
Current therapy with proton pump inhibitors
The intermittent use of proton-pump inhibitors (PPI), H-antagonists and antacids (including carafate) is only allowed within these guidelines:\r\n* PPI until day (D)- prior to the first dose of alisertib and prohibited for the duration of the study,\r\n* H antagonists until D- and after the dosing of alisertib is done,\r\n* Antacid formulations until  hours before dosing and after  hours following dosing
Inability to tolerate a proton pump inhibitor (PPI)
No concomitant use of proton pump inhibitors (PPI) is allowed; any prior PPI must be discontinued at least one week before receiving MLN (TAK-)
Proton RT
Regular (>=  times per week) use of drugs that alter the pH of the gastrointestinal tract (GI) tract, such as proton pump inhibitors (PPI) and antacids; exceptions: individuals who use prescription PPIs and have approval from their primary health care provider to replace the PPI with an H receptor agonist, i.e. ranitidine, for the duration of the trial will be eligible
Participants who regularly (>=  times per week) use drugs that alter the pH of the gastrointestinal (GI) tract, such as proton pump inhibitors (PPI) and antacids; exceptions: individuals who use prescription PPIs and have approval from their primary health care provider to discontinue for the duration of clinical trial participation may be enrolled; an alternate drug to control gastroesophageal reflux disease (GERD)/peptic ulcer disease (PUD) symptoms will be suggested
Chronic proton pump inhibitor (PPI) use or histamine (H) blocker use that cannot be temporarily discontinued (at least  hours)
Proton pump inhibitor use at least once daily for at least twelve months prior to enrolment, and stable dose of PPI for the three months before enrolment
No use of proton pump inhibitors (PPIs) within the previous  months
Treatment with long-acting proton pump inhibitors that cannot be discontinued  days prior to the start of study drug and during the course of the study
Chronic proton pump inhibitor, H-blocker (i.e., ranitidine, famotidine), and/or calcium carbonate use
Concurrent use of any proton pump inhibitors