Prior radiotherapy within weeks of initiating treatment; Must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis Prior surgery or radiotherapy within days of initiating study drug(s). Patients must have recovered from all radiation-related toxicities, not required corticosteroids and have not had radiation pneumonitis. Prior surgery or radiotherapy within days of initiating therapy. Patients must have recovered from all radiation-related toxicities, and not required corticosteroids. Has recovered from all radiation-related toxicities, does not require corticosteroids, and has not had radiation pneumonitis Has received prior radiotherapy within weeks of start of study treatment. Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis. A -week washout is permitted for palliative radiation (=< weeks of radiotherapy) to non-central nervous system (CNS) disease Prior radiotherapy or gamma knife within weeks of study treatment for non-brain metastasis; subjects must have recovered from all radiation related toxicities Prior radiotherapy or gamma knife within weeks of study treatment for non-brain metastasis; subjects must have recovered from all radiation related toxicities Received prior radiotherapy within weeks of start of study treatment. Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis. A -week washout is permitted for palliative radiation (? weeks of radiotherapy) to non-central nervous system (CNS) disease. REGISTRATION TO TREATMENT (STEP ): Patient must not have had prior chemotherapy, targeted small molecule therapy (aside from imatinib, dasatinib, or nilotinib), or radiation therapy within weeks prior to study registration; patients also must have recovered from all adverse events due to a previously administered agent\r\n* Note: Patients with =< grade neuropathy are an exception to this criterion and may qualify for the study\r\n* NOTE: Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis; a -week washout is permitted for palliative radiation (=< weeks of radiotherapy) to non-central nervous system [CNS] disease) REGISTRATION TO TREATMENT (STEP ): Patient must not have had prior chemotherapy, targeted small molecule therapy (aside from imatinib, dasatinib, or nilotinib), or radiation therapy within weeks prior to study registration; patients also must have recovered from all adverse events due to a previously administered agent\r\n* NOTE: Patients with =< grade neuropathy are an exception to this criterion and may qualify for the study\r\n* NOTE: Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis; a -week washout is permitted for palliative radiation (=< weeks of radiotherapy) to non-CNS disease DOSE ESCALATION COHORT: Subjects who have had prior radiotherapy within weeks of therapy; subjects must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis DOSE EXPANSION COHORT: Subjects who have had prior radiotherapy within weeks of therapy; subjects must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis Has received prior radiotherapy within weeks of start of study treatment; participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis; a -week washout is permitted for palliative radiation (=< weeks of radiotherapy) to non-central nervous system (CNS) disease Have undergone chest irradiation within weeks prior to study drug administration, have not recovered from all radiation-related toxicities, or requires corticosteroids. A -week washout is permitted for focal palliative radiation to non-central nervous system disease. Prior radiotherapy within weeks of therapy; Must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis.