Patients with no elevations of serum and/or CSF HCGbeta and AFP must have histological diagnosis of malignant GCT or germinoma
SURGICAL STUDY (STRATUM ): Patients must have recurrent or refractory disease with a histological diagnosis at either the time of diagnosis or at the time of recurrence of one of the following: \r\n* HGG\r\n* Medulloblastoma, \r\n* CNS embryonal tumor (NOS), \r\n* Ependymoma, or \r\n* ATRT
Histologically confirmed diagnosis of advanced unresectable or metastatic STS, not amenable to curative treatment and after available standard therapies have failed to provide clinical benefit. Note: Participants with a diagnosis of Grade  liposarcoma (atypical lipomatous neoplasms) are eligible if there is histological or radiographic evidence of evolution to more aggressive disease.
Histological Diagnosis
Histological diagnosis of nonsquamous NSCLC.
Histological or cytological diagnosis of solid cancer or lymphoma that is considered incurable and without therapies with established benefit. Biopsy is not necessary for subjects with known prior diagnosis and clinical or radiographic evidence of recurrence.
Patients must have histological verification of the diagnosis of Langerhans cell histiocytosis according to the criteria described in Section .
Part B only: Participants must have histologically confirmed diagnosis of B-cell iNHL, with histological subtype; prior treatment with ? prior chemotherapy- or immunotherapy-based regimens for iNHL
Patients with a histological diagnosis of lymphomas and/or leukemias
Histological diagnosis of breast cancer
Have a histological diagnosis of advanced STS (by local pathology review), for which treatment with doxorubicin, ifosfamide and mesna is deemed appropriate by the investigator.
For the treatment phase: Patients with any histological subtype are eligible
Tumor tissue must be available for review to confirm histological diagnosis
Have histologically or cytologically documented HCC (documentation of original biopsy for diagnosis is acceptable if tumor tissue is unavailable) or clinical diagnosis by American Association for the Study of Liver Diseases (AASLD) criteria in cirrhotic subjects is required; for subjects without cirrhosis histological confirmation is mandatory
Histologically confirmed diagnosis of CD positive iNHL with histological subtype limited to:
Histological grade I, II, or III according to the modified Bloom Richardson scale
Histologically confirmed diagnosis of Indolent non-Hodgkin's lymphoma (iNHL) in CD positive patients, with histological subtype limited to:
Histologic confirmation is not required for this if the patient has neurofibromatosis type  (NF-) with magnetic resonance imaging (MRI) findings consistent with optic pathway glioma or juvenile pilocytic astrocytoma (JPA); any other tumors will need histological confirmation, either at the time of diagnosis or at the time of recurrence; the histological diagnosis includes World Health Organization (WHO) grade I JPA
Histological documentation of mCRC
Histologically confirmed diagnosis of adenocarcinoma of the prostate within one year of study entry; evaluation can happen outside of MD Anderson as long as histological confirmation takes place at MD Anderson
Histological diagnostic material available for review.
All patients must have histological proof of malignant cancer, which is metastatic; histological proof may be obtained from the primary tumor or another metastatic site; however, cytology alone is not an acceptable method of diagnosis
Patients with NO elevation of serum and/or CSF HCGB and AFP MUST have histological diagnosis of malignant germ cell tumor (GCT) or germinoma
Histological diagnosis of synovial sarcoma
Histological diagnosis of recurrent or metastatic cervical, vaginal, or vulvar cancer
Appropriate treatment history for histological entity.
Histological diagnosis of ATC made through surgical resection is also acceptable.
For Part B: All participants must have a histological evidence of their advanced or metastatic cancer and prescreened alterations in a defined pathway.
For Part D: All participants must have histological evidence of advanced or metastatic cancer and prescreened alterations in a defined pathway.
other histological type of lymphoma
Histologically confirmed diagnosis of indolent B-cell NHL, with histological subtype limited to the following:
Histological or cytologic diagnosis of squamous cell cancer
Patients with histological or cytologically documented hepatocellular carcinoma (HCC) (documentation of original biopsy for diagnosis is acceptable if tumor tissue is unavailable) or clinical diagnosis by American Association for the Study of Liver Diseases (AASLD) criteria in cirrhotic subjects is required; for subjects without cirrhosis histological confirmation is mandatory
Subjects must have a histological diagnosis of cancer
Have a clinical diagnosis of cutaneous T cell lymphoma CTCL, including documentation of a skin biopsy within the prior  years with histological findings consistent with CTCL (atypical epidermotropic or folliculocentric T-cells)
Histologically confirmed diagnosis of indolent B-cell NHL, with histological subtype limited to the following:
Histological confirmed diagnosis of relapsed intracranial GB
Have histological evidence of a diagnosis of HCC not amenable to curative surgery
Age <  years at time of diagnosis for all histological diagnosis
Histologically confirmed diagnosis of B-cell iNHL, with histological subtype limited to the following:
Histological diagnosis of GIST.
Histologically confirmed diagnosis of B-cell iNHL, with histological subtype limited to the following:
Availability of histological material (primary tumor or metastases) for review of the diagnosis and demonstration of PAX-PPARgamma fusion gene
Patient had histological confirmed diagnosis of osteosarcoma of the recurrent sample.
Has histological diagnosis of a primary solid tumor malignancy that meets study criteria
Histological diagnosis of cancer
Histological diagnosis of high-grade osteosarcoma
Subjects with histological diagnosis of incurable cancer (solid tumor)
All patients with a histological diagnosis of cancer
Women initially diagnosed with breast cancer by histological tissue diagnosis in  or later
Histological diagnosis of NET
Histological diagnosis of glioma or
Participant must have either radiological (presumptive) or established (proven) histological diagnosis of a brain tumor or lesion
Histological diagnosis of prostate, pancreatic or bladder cancer