Any hemorrhage or bleeding event >= NCI CTCAE v. grade within weeks prior to study registration Any hemorrhage or bleeding event >= NCI CTCAE grade within weeks prior to start of study medication Any hemorrhage or bleeding event >= NCI CTCAE grade within weeks prior to start of study medication Subject with any pulmonary hemorrhage/bleeding event of NCI-CTCAE v. Grade or higher within months before first dose of study treatment any other hemorrhage/bleeding event of NCI-CTCAE v. Grade or higher within months before first dose of study treatment Any hemorrhage or bleeding event >= NCI CTCAE grade within weeks prior to start of study medication Any hemorrhage or bleeding event ? NCI CTCAE Grade within weeks prior to study registration Any hemorrhage or bleeding event >= CTCAE grade within weeks prior to the start of study medication Any hemorrhage or bleeding event >= NCI CTCAE grade within weeks prior to start of study medication Any hemorrhage or bleeding event >= NCI CTCAE grade within weeks prior to start of study medication Any hemorrhage or bleeding event ? NCI CTCAE Grade within weeks prior to start of study medication. Any hemorrhage or bleeding event >= NCI CTCAE grade within weeks prior to start of study medication Any hemorrhage or bleeding event >= NCI CTCAE grade within weeks prior to start of study medication Any hemorrhage or bleeding event >= NCI CTCAE grade within weeks prior to start of study medication Any hemorrhage or bleeding event >= NCI CTCAE grade within weeks prior to start of study medication Subject with any pulmonary hemorrhage/bleeding event of NCI-CTCAE v. grade or higher within weeks before treatment; any other hemorrhage/bleeding event of NCI-CTCAE v. grade or higher within weeks before treatment Subject with any pulmonary hemorrhage/bleeding event of NCI-CTCAE v. grade or higher within weeks before randomization; any other hemorrhage/bleeding event of NCI-CTCAE v. grade or higher within weeks before study entry Subject with any pulmonary hemorrhage/bleeding event of NCI-CTCAE v. grade or higher within weeks before enrollment; any other hemorrhage/bleeding event of NCI-CTCAE v. grade or higher within weeks before enrollment Any hemorrhage or bleeding event ? NCI CTCAE Grade within weeks prior to study registration. Any hemorrhage or bleeding event >= NCI CTCAE grade within weeks prior to start of study medication Any hemorrhage or bleeding event >= NCI CTCAE v.. grade within weeks prior to start of study medication Have had a hemorrhage or a bleeding event >/=Grade (NCI-CTCAE v .) within weeks prior to the initiation of study treatment. Subjects with evidence or history of bleeding diathesis; any hemorrhage or bleeding event NCI-CTCAE Grade ? or higher within weeks of start of investigational treatment Any other hemorrhage/bleeding event >= NCI-CTCAE grade within weeks of enrollment Any hemorrhage or bleeding event >= NCI CTCAE grade within weeks prior to start of study medication