No prior radiotherapy or chemotherapy, with the exception of dexamethasone, which is allowed Diagnosis of immunodeficiency or treatment with systemic immunosuppressive therapy within days prior to the first dose of trial treatment, other than dexamethasone for the underlying disease under investigation, as noted in the inclusion criteria; Stable dose of dexamethasone mg or less for at least days prior to initiation of treatment Dexamethasone: days Stable dose of dexamethasone mg or less for days prior to initiation of treatment Stable dose of dexamethasone mg or less for days prior to initiation of treatment Stable dose of dexamethasone mg or less for at least days prior to initiation of treatment Stable dose of dexamethasone mg or less for at least days prior to initiation of treatment Ongoing treatment with immunosuppressive drugs or dexamethasone > mg Daily dexamethasone > mg at the time of registration Dexamethasone dose =< mg daily If applicable, stable dose of dexamethasone mg or less for days prior to initiation of treatment Use of systemic glucocorticoid (eg, prednisone, dexamethasone) within days prior to the start of study medication. Time interval from last systemic chemotherapy (not including low dose dexamethasone) more than weeks prior to initiation of ABC; patients receiving high dose dexamethasone defined as mg dexamethasone a day for days will need weeks washout prior to initiation of ABC The subject requires dexamethasone =< mg daily on a stable dose No dexamethasone (or other corticosteroid bioequivalent) within one week of vaccination initiation Patients who are receiving dexamethasone must be on a stable dose for at least week prior to study entry Be willing to use dexamethasone mouthwash as directed Noncompliant with oral medication and/or dexamethasone mouth wash Any anti-myeloma drug treatment within days before randomization, including dexamethasone. Dexamethasone dose less than or equal to mg daily at time of study enrollment Glucocorticoid therapy within the days prior to randomization that exceeds a cumulative dose of mg of dexamethasone or mg prednisone Stable dose of glucocorticoids pre-therapy; if patients are receiving dexamethasone, the dose of dexamethasone should not increase during the hours prior to initiation of therapy If patient is on dexamethasone, must be on stable or decreasing dose of dexamethasone for >= days; if patient is on different glucocorticoid e.g., prednisone, must be converted to dexamethasone prior to enrollment Prior treatment for myeloma except for one cycle of dexamethasone Use of systemic glucocorticoid (eg, prednisone, dexamethasone) within days prior to the start of study medication Participants in the combination therapy arms must be eligible to receive pomalidomide/dexamethasone, bortezomib/dexamethasone or lenalidomide/dexamethasone or other approved agents per current prescribing information for MM. Patients with central nervous system (CNS) tumors who are receiving dexamethasone must have been on a stable or decreasing dose of dexamethasone for the days prior to enrollment Patients for whom dexamethasone is contraindicated. Glucocorticoid therapy within days prior to randomization that equals or exceeds a cumulative dose of mg of dexamethasone Patients receiving corticosteroids aside from dexamethasone treatment directed at leukemia Resistance to high-dose dexamethasone used in the last line of therapy Use of dexamethasone for cancer related fatigue Off dexamethasone treatment for ? weeks before the first dose of study drug. No ongoing requirement for dexamethasone or anti-epileptic drugs.