Patients must not have any uncontrolled intercurrent illness including (not limited to): symptomatic congestive heart failure (CHF) (New York Heart Association [NYHA] III/IV), unstable angina pectoris or coronary angioplasty, or stenting within  weeks prior to registration, unstable cardiac arrhythmia (ongoing cardiac dysrhythmias of NCI Common Terminology Criteria for Adverse Events [CTCAE] version [v]  grade >= ), known psychiatric illness that would limit study compliance, intra-cardiac defibrillators, known cardiac metastases, or abnormal cardiac valve morphology (>= grade )\r\n* Note: Patients with history of CHF or patients who are deemed at risk because of underlying cardiovascular disease or exposure to cardiotoxic drugs should have an electrocardiogram (EKG) and echocardiogram (ECHO), as clinically indicated, at baseline and at the start of each cycle; patients who have evidence at baseline (or subsequently) of CHF, myocardial infarction (MI), cardiomyopathy, or myositis cardiac evaluation (NYHA I/II) should have additional consult by a cardiologist, including review of EKG, creatine phosphokinase (CPK), troponin, echocardiogram, as clinically indicated
No cardiac arrhythmias within  days of registration
History of unstable or deteriorating cardiac disease within the previous  months prior to screening including but not limited to the following:
Any of the following cardiac conditions:
Uncontrolled cardiac disease
- Patient presenting with cardiac disorders defined by at least one of the following conditions:
Patient with recent cardiac history (within  months) of:
Symptomatic cardiac disease
Have a serious cardiac condition.
History of cardiac disease: myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular function within  months prior to randomization; history of documented CHF; or documented cardiomyopathy.
Participant has active cardiac disease or a history of cardiac dysfunction including any of the following:
EXCLUSION - TREATMENT: Cardiac criteria: prolonged QT syndrome; atrial fibrillation/flutter; myocardial infarction within the last  months; cardiac echocardiography with LVSF ? % or LVEF ? %; cardiac dysfunction NYHA III or IV; cardiac echocardiography with clinically significant pericardial effusion
Any of the following cardiac criteria:
Any of the following cardiac criteria:
Subject is undergoing one of the following open elective cardiac, general, or urological surgical procedures: Cardiac procedure (Epicardium); Cardiac procedure (aortic anastomosis or aortotomy suture line); Liver resection; Total splenectomy; On-clamp partial nephrectomy; or Radical nephrectomy.
Any of the following cardiac criteria:
Patients with active renal, cardiac (congestive cardiac failure, myocardial infarction, myocarditis), or pulmonary disease
Have a serious cardiac condition.
Resting QTcF ? msec at pretreatment (baseline) or other cardiac or cardiac repolarization abnormality
Patients with known cardiac shunts
History of the following cardiac conditions:
Any of the following cardiac criteria:
Myocardial infarction in preceding  weeks; history of uncontrolled cardiac arrhythmias or family history of sudden cardiac death
The patient has cardiac conditions defined per protocol
cardiac conditions, including
Any of the following cardiac criteria:
Serious cardiac condition within the last  months
Donor must not have any medical condition which would make apheresis more than a minimal risk, and should have the following: \r\n* Family members will be considered for donation if they do not have a history of known cardiac problem and do not have abnormal cardiac findings by physical examination; those with a history of cardiac problems or abnormal cardiac findings by physical examination should undergo a stress evaluation or be evaluated by a cardiologist and deemed eligible to donate
Have cardiac pacemakers
No symptoms of uncontrolled cardiac disease
History of cardiac disease, in particular, supraventricular tachycardia
Active heart (cardiac) disease as defined in the protocol
No active co-morbid cardiac condition such as active CHF or CAD
Any of the following cardiac conditions:
Any of the following cardiac criteria:
Cardiac or cardiac repolarization abnormality
Myocardial infarction, cardiac arrest or cardiac failure within  year before screening/baseline visit;
Patients with unstable cardiac status including:
Patient presenting with at least one of the following feature: ischemic heart disease, cardiac failure, conduction disorders or arrythmia
Cardiac conditions per protocol
Patients with intra-cardiac defibrillators
History of, or at risk for, cardiac disease, as evidenced by  or more of the following conditions:
Any of the following cardiac conditions:
Cardiac:
Abnormal cardiac status
History or evidence of cardiac disease as indicated by any of the following:
Patient has active cardiac disease or a history of cardiac dysfunction
Patients with a known history of cardiac disease. This includes:
Known cardiac metastases
Any of the following cardiac conditions:
Known cardiac metastases
Have abnormal cardiac findings.
Cardiac disease
Any of the following cardiac criteria:
Active cardiac disease
Any of the following cardiac criteria:
Presence of cardiac metastases
Patient has active cardiac disease or a history of cardiac dysfunction including any of the following:
History of any of the following cardiac conditions:\r\n* Angina requiring treatment with long-acting nitrates\r\n* Angina requiring treatment with short-acting nitrates within  days of planned tadalafil administration\r\n* Unstable angina within  days of visit \r\n* Positive cardiac stress test without documented evidence of subsequent, effective cardiac intervention
Significant cardiac conditions or events such as reduced cardiac functions, symptomatic cardiac arrhythmia requiring treatment, congenital long QT syndrome, history of drug-induced QT prolongation, or QTcF correction unmeasurable or more than  ms.
Active cardiac disease, defined as (but not limited to):
Patients with cardiac atrial or cardiac ventricular lymphoma involvement
Evidence of significant cardiac disease, for example: symptomatic cardiac heart failure (CHF, NYHA class ), complete bundle branch block, significant atrial or ventricular tachyarrhythmias and any unstable cardiac arrhythmias requiring medication.
Left ventricular ejection fraction < %; Note: poor cardiac function predicts for cardiac morbidity, not cardiac mortality; therefore, a cardiology consultant may override the criteria for eligibility
History or evidence of cardiac risk.
History of cardiac disease
Active cardiac disease or a history of cardiac dysfunction.
Cardiac conditions
Types of cardiac operations permitted:
Patients with history of cardiac dysrhythmia
Patient's with any metallic cardiac implant
Any of the following cardiac criteria: CHF > Class II, cardiac ventricular arrhythmia requiring therapy, unstable angina or new-onset angina, QTcF interval >ms, abnormal ECHO or MUGA at baseline (LVEF <%).
History of cardiac disease
Patients with intra-cardiac defibrillators
Subjects with intra-cardiac defibrillators or permanent pacemakers
History or evidence of cardiac risk
Known cardiac/cardiopulmonary disease
History of cardiac disease
Known cardiac/cardiopulmonary disease
Cardiac exclusions:
Patients with intra-cardiac defibrillators
Active heart (cardiac) disease or a history of cardiac dysfunction as defined in the protocol
History of severe cardiac disease.
Major cardiac disease
Has cardiac status as described in protocol
Patients with intra-cardiac defibrillators or permanent pacemakers.
Cardiac metastases
Active cardiac disease;
Current or uncontrolled cardiac disease
Patients with unstable cardiac status including:
Have a serious cardiac condition
Presence of severe cardiac disease
Cardiac pacemakers
Patients with documented advanced cardiac or renal disease
Severe cardiac disease
No known cardiac history (i.e., heart failure, myocardial infarction, or radiation-induced cardiac dysfunction)
History of cardiac arrhythmias
Unstable cardiac condition
Known cardiac shunt
Patients with known cardiac shunt
PATIENT: Patients with cardiac shunts or unstable cardiopulmonary conditions
Cardiac disease (cardiac viability assessment)
Patients with cardiac shunts or unstable cardiopulmonary conditions.
Patients with cardiac shunts
Patients with cardiac shunts
Patients with cardiac shunts
Known or suspected: cardiac shunts
History of any clinically unstable cardiac condition including class III/IV cardiac failure or right-to left shunts
Severe cardiac disease
Abnormal cardiac status with any of the following:
Known, clinically important cardiac or respiratory disease