Allergy or hypersensitivity to components of the cobimetinib formulations Previously identified allergy or hypersensitivity to components of the cabozantinib formulations Previously identified allergy or hypersensitivity to components of the study treatment formulations Previously identified hypersensitivity to components of the formulations used in this study Known allergy or hypersensitivity to the components of the doxorubicin, cyclophosphamide, carboplatin, or paclitaxel formulations. Known allergy or hypersensitivity to liposomal or pegylated G-CSF formulations. History of severe hypersensitivity reactions to components of the cobimetinib, atezolizumab, or pembrolizumab formulations Previously identified allergy or hypersensitivity to any component of the study treatment formulations Previously identified allergy or hypersensitivity to components of the study treatment formulations Has a previously identified allergy or hypersensitivity to components of the study treatment formulations Known allergy or hypersensitivity to study drug formulations Previously identified allergy or hypersensitivity to components of the study treatment formulations Patients with a known allergy to any component of the study treatment formulations Previously identified allergy or hypersensitivity to components of the study treatment formulations Previously identified allergy or hypersensitivity to components of the study treatment formulations Allergy or hypersensitivity to components of the cobimetinib formulations Patient has a known allergy to any component of the study treatment formulations Previously identified allergy or hypersensitivity to components of the study treatment formulations. Allergy or hypersensitivity to components of the cobimetinib formulations The patient has a previously-identified allergy or hypersensitivity to components of the study treatment formulations. History of serious allergy or reaction to any component of RICE or RDHAP formulations that would prevent administration