Each patient must be willing to participate as a research participant and must sign an informed consent form. Each patient much be willing to participate as a research subject and must sign an informed consent form Each patient must be willing to participate as a research subject and must sign an informed consent form Each patients must be willing to participate as a research subject and must sign an informed consent form Each patient must be willing to participate as a research subject and must sign an informed consent form Each patient must be willing to participate as a research subject and must sign an informed consent form Each patient must be willing to participate as a research subject and must sign an informed consent form Each patient must be willing to participate as a research subject and must sign an informed consent form Each patient must be willing to participate as a research subject and must sign an informed consent form