No evidence of dyspnea at rest Severe dyspnea at rest, due to complications of advanced malignancy, or requiring supplementary oxygen therapy. Severe dyspnea at rest due to complications of advanced malignancy or requiring supplementary oxygen therapy Severe dyspnea at rest due to complications of advanced malignancy or current requirement for continuous oxygen therapy No uncontrolled hypertension (>= /), unstable diabetes mellitus, dyspnea at rest, or chronic therapy with oxygen. Severe dyspnea at rest due to complications of advanced malignancy, or requiring supplementary oxygen therapy. No clinical indications such as evidence of dyspnea at rest, or exercise intolerance due to pulmonary insufficiency Within weeks prior to study enrollment: No evidence of dyspnea at rest Adequate pulmonary function defined as no evidence of dyspnea at rest No evidence of dyspnea at rest No evidence of dyspnea at rest and no exercise intolerance No evidence of dyspnea at rest No evidence of dyspnea at rest, and No evidence of dyspnea at rest Patients must have clinically normal lung function as manifested by no dyspnea at rest and no oxygen requirement Lung disease resulting in dyspnea at rest. Normal lung function as manifested by no dyspnea at rest and no oxygen requirement Dyspnea with moderate exertion No evidence of dyspnea at rest Dyspnea at rest due to complications of advanced malignancy or other disease requiring continuous oxygen therapy. Evidence of dyspnea at rest or oxygen saturation (<=) percent (%). Current dyspnea at rest of any origin, or other diseases requiring continuous oxygen therapy. Normal lung function with no dyspnea at rest, pleural effusion or oxygen requirement No dyspnea at rest No evidence of dyspnea at rest Dyspnea at rest or other diseases that require continuous oxygen therapy Dyspnea with moderate exertion No evidence of dyspnea at rest At least moderate dyspnea defined by a BDI score of or less in the self-administered computerized versions of the baseline and transition dyspnea indexes (SAC-BDI/TDI); (this cutoff score is close to the score of . used to define \moderate dyspnea\ in the publication that validated the instrument and is selected by attending physicians in the pulmonary service as a good indication of \ moderate dyspnea\ in clinical practice; a typical person with BDI of , for example, would be a year old woman who has to pause when walking because of dyspnea and/or has eliminated doing an activity because of dyspnea) Severe dyspnea at rest due to complications of advanced malignancy or requiring current continuous oxygen therapy Current dyspnea at rest, owing to complications of advanced malignancy or any requirement for supplemental oxygen to perform activities of daily living Dyspnea with an average intensity >= on the dyspnea NRS (range -) over the past week. Dyspnea numeric rating scale at rest >= of (average over last hour) Average dyspnea Borg Scale >= of with severe exertion over the past week Resting dyspnea modified Borg Scale > of at enrollment Breakthrough dyspnea, defined as dyspnea with an average intensity level over the past days of at least / on a numeric rating scale upon significant exertion or continuous dyspnea =< / with worsening upon significant exertion Dyspnea at rest >= / at the time of enrollment Patients with ESAS > / on dyspnea Subject has a history of at least ipsilateral pleural effusion causing dyspnea that responded to thoracentesis where the lung expanded and the dyspnea was improved. Breakthrough dyspnea, defined in this study as dyspnea on exertion with an average intensity level >= / on the numeric rating scale Dyspnea at rest >= / at the time of enrollment Breakthrough dyspnea, defined in this study as dyspnea on exertion with an average intensity level >= / on the numeric rating scale Dyspnea at rest >= / at the time of enrollment Dyspnea with an average intensity level > / on the numeric rating scale over the past week