Has a concomitant medical condition that would increase the risk of toxicity, in the opinion of the Investigator or Sponsor. Presence of any severe or uncontrolled concurrent medical condition felt in the opinion of the investigator to increase the risk of serious toxicity from the study therapy Has a concomitant medical condition that would increase the risk of toxicity, in the opinion of the Investigator Any co-morbid medical condition that may put the patient at significant risk for toxicity Significant organ compromise that will increase risk of toxicity or mortality Unstable coronary artery disease or other medical condition (such as type diabetes) that, in the Investigator's opinion, might increase the risk to the patient No serious medical illness that would potentially increase patients risk for toxicity Serious medical illness or severe debilitating pulmonary disease that would potentially increase the patients risk for toxicity Has a concomitant medical condition that would in the opinion of the Investigator increase the risk of toxicity. Serious medical illness that would potentially increase patients risk for toxicity Serious medical illness that would potentially increase patients risk for toxicity Serious medical illness that would potentially increase patients risk for toxicity Serious medical illness that would potentially increase patients risk for toxicity Concomitant medical condition that would increase the risk of toxicity, in the opinion of the Investigator or Sponsor Concurrent medical condition which may increase the risk of toxicity, including:\r\n* Hypercalcemia of any cause\r\n* Untreated hyperparathyroidism\r\n* Pagets disease of bone Serious medical illness that would potentially increase patients risk for toxicity Presence of any severe or uncontrolled concurrent medical condition which, in the opinion of the investigator, would increase the risk of serious toxicity from the study drugs Serious medical illness that would potentially increase patients risk for toxicity Serious medical illness that would potentially increase patients risk for toxicity Presence of any severe or uncontrolled concurrent medical condition which, in the opinion of the investigator, would increase the risk of serious toxicity from the study drugs Any co-morbid disease that would increase risk of toxicity as determined by PI Serious medical illness that would potentially increase patients risk for toxicity Any medical condition that in the investigators opinion could interfere with interpretation of study or toxicity, or increase the risk to the patient related to potential toxicity Has a concomitant medical condition that would increase the risk of toxicity, in the opinion of the Investigator or Sponsor. Any co-morbid medical disorder that may increase the risk of toxicity, in the opinion of the investigator or sponsor Has a concomitant medical condition that would increase the risk of toxicity, in the opinion of the Investigator or Sponsor A concomitant medical condition that would increase the risk of toxicity, in the opinion of the Investigator or Sponsor.