Definitive clinical or radiologic evidence of metastatic disease; required imaging studies must have been performed within days prior to randomization Definitive clinical or radiologic evidence of metastatic disease Definitive clinical or radiologic evidence of metastatic disease Definitive clinical, radiologic, or pathologic evidence of metastatic disease (M) or lymph node involvement (N) Definitive clinical or radiologic evidence of metastatic disease; no nodal involvement or evidence of metastatic disease allowed as defined by screening of the pelvis Definitive evidence of metastatic meningioma Known definitive clinical or radiologic evidence of metastatic disease Definitive clinical or radiologic evidence of metastatic disease. Definitive clinical or radiologic evidence of metastatic disease, as documented by the treating institution Clinical or radiologic evidence of local or regional recurrence of disease or metastatic disease prior to or at the time of study entry Definitive clinical or radiologic evidence of metastatic disease; imaging must have been performed no greater than days prior to initiation of chemotherapy Definitive clinical or radiologic evidence of distant (beyond cervical lymph node and neck tissue) metastatic disease. Definitive clinical or radiologic evidence of metastatic disease Definitive clinical or radiologic evidence of metastatic disease or adenopathy below the clavicles Definitive clinical or radiologic evidence of metastatic disease; (chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within days prior to randomization) Clinical or radiologic evidence of local or regional recurrence of disease or metastatic disease prior to or at the time of study entry Definitive clinical or radiological evidence of metastatic disease Definitive clinical or radiologic evidence of progressive disease Definitive clinical or radiologic evidence of metastatic disease. Definitive clinical or radiologic evidence of metastatic disease; indeterminant lung nodules less than mm are acceptable Definitive clinical or radiologic evidence of metastatic disease; pN disease is not allowed (positive common iliac node) Clinical or radiologic evidence of distant metastatic disease other than small volume (<. cm) nodes, this should be tested within months from enrollment; Presence of active nodal metastases (e.g., radiologic or clinical evidence of current nodal disease) Definitive clinical or radiologic evidence of metastatic disease; if applicable Definitive evidence of multifocal disease Evidence of disease progression or metastatic disease during or following definitive local therapy documented in the - to -week post-definitive local therapy scans