Diagnosis of rectal adenocarcinoma Prostate adenocarcinoma (PAC) Histologically documented adenocarcinoma prostate cancer confirmed by a pathology report from prostate biopsy or a radical prostatectomy specimen; if prostatic tumor is of mixed histology, > % of the tumor must be adenocarcinoma Patients with cytologic evidence of adenocarcinoma in situ Histologically proven adenocarcinoma of the prostate Histologic confirmation of adenocarcinoma of the prostate Histologic confirmation of prostate adenocarcinoma diagnosis Evidence of neuroendocrine tumor, duodenal adenocarcinoma, or ampullary adenocarcinoma Histological proof of adenocarcinoma of the prostate Histologically-proven prostate adenocarcinoma\r\n* Gleason score - based on a review of the prostate core biopsies at Moffitt Cancer Center Does not have a diagnosis of prostate adenocarcinoma Histologic confirmation of diagnosis of adenocarcinoma of the prostate will be required by biopsy Documented pathologic confirmation of prostate adenocarcinoma Histologically proven adenocarcinoma of the prostate obtained within months of screening; patients in whom a diagnosis of high-risk localized or locally-advanced prostatic adenocarcinoma is suspected based on a serum PSA > ng/mL or clinical T disease by digital rectal examination, but who have not yet undergone diagnostic prostate biopsy, will be eligible for screening and initial MRI and targeted prostate cancer biopsies which will be obtained at the same time as diagnostic biopsies; those patients in whom the diagnostic biopsies confirm prostatic adenocarcinoma will be permitted to continue with study treatment if they meet all additional eligibility criteria Patients with adenocarcinoma of the prostate that in the opinion of the urologist could be resected after response to systemic therapy; ductal adenocarcinoma is permitted Patients with cytologic evidence of adenocarcinoma in situ Histological or cytologic evidence of adenocarcinoma of the prostate confirmed at local institution Diagnosis of adenocarcinoma of the prostate, confirmed by H. Lee (L.) Moffitt Cancer Center review Patients with histopathologically proven adenocarcinoma of the prostate adenocarcinoma of the prostate that has been surgically treated with a post-treatment PSA that is undetectable; Part B: Esophagogastric Adenocarcinoma: Histologic confirmation of adenocarcinoma of the prostate by biopsy; Patients with a histologic diagnosis of adenocarcinoma of the prostate Evidence or history of metastatic adenocarcinoma of the prostate Histologically proven adenocarcinoma of the prostate Adenocarcinoma of the prostate Histologically proven adenocarcinoma of the prostate Grade adenocarcinoma Histologically proven adenocarcinoma of the prostate Histologically documented diagnosis of adenocarcinoma of the prostate (PCa) with no histologic variants Histologic proof of prostate adenocarcinoma Histologic diagnosis of adenocarcinoma of the prostate Patients with a histologic diagnosis of adenocarcinoma of the prostate Adenocarcinoma of the Prostate Patients with verrucous or adenocarcinoma Prior to randomization, have histological confirmation that CRC lesions were adenocarcinoma (subtypes of adenocarcinoma, e.g. mucinous adenocarcinoma are allowed). Subjects with CRC lesions of other histological types, including mixed type with predominant adenocarcinoma, will not be eligible to be randomized to study treatment. The subject has a proven histologic diagnosis of prostate adenocarcinoma, but may have undergone prior surgery and/or radiation Adenocarcinoma of the breast. Histologic proof of adenocarcinoma of the prostate with clinical evidence of metastatic disease to the bone Histologically-documented prostatic adenocarcinoma in >= cores Histologic diagnosis of prostate adenocarcinoma plus > % immunohistochemical staining for neuroendocrine markers (chromogranin, synaptophysin or neuron specific enolase) Histologic confirmation of adenocarcinoma of the prostate Histologically proven adenocarcinoma of the prostate Histologically proven adenocarcinoma of the prostate Adenocarcinoma of the prostate Histologic documentation of adenocarcinoma of the prostate Confirmed metastatic adenocarcinoma of the prostate that is unresponsive or refractory to hormonal therapy Histologically or cytologically proven adenocarcinoma of the prostate; if pathology is unavailable, the principal investigator (PI) may also make a determination of prostate cancer based on unequivocal clinic data Histologic confirmation of adenocarcinoma of the prostate The subject has a diagnosis of adenocarcinoma of the prostate Male subjects - years of age diagnosed with adenocarcinoma of the prostate; COHORT I: Biopsy proven adenocarcinoma of the prostate Histopathological proven prostate adenocarcinoma Pathologically proven prostate adenocarcinoma Biopsy-proven prostate adenocarcinoma Biopsy proven prostate adenocarcinoma Histopathologically proven prostate adenocarcinoma Biopsy proven prostate adenocarcinoma Histopathological proven prostate adenocarcinoma Biopsy proven prostate adenocarcinoma Biopsy proven prostate adenocarcinoma Biopsy proven prostate adenocarcinoma Biopsy proven adenocarcinoma of the prostate Biopsy proven prostate adenocarcinoma Histopathological proven prostate adenocarcinoma A diagnosis of prostate adenocarcinoma on more than one set of prostate biopsies, on separate calendar dates Biliary tract adenocarcinoma.