* Platelets >= x ^ cells/ L (unsupported, defined as no platelet transfusion within days) Hemoglobin >= g/dl (unsupported) Absolute neutrophil count >= / mm^ (unsupported) and documented within days prior to registration and within days prior to the start of treatment Platelets >= ,/ mm^ (unsupported) and documented within days prior to registration and within days prior to the start of treatment Documented within days of registration: Absolute neutrophil count >= /ul (unsupported) Documented within days of registration: Platelets >= ,/ul (unsupported) Platelets >= , cells /uL (unsupported, defined as no platelet transfusion within days) INCLUSION CRITERIA FOR STRATUM C: Platelets >= , cells/uL (unsupported, defined as no platelet transfusion within days) Absolute neutrophil count >= ,/uL (unsupported), within days of registration and within days of the start of treatment Platelets >= ,/L (unsupported), within days of registration and within days of the start of treatment Platelets >= ,/ul (unsupported) Platelets >= , x ^/L unsupported by transfusions (within days of study registration) Hemoglobin >= g/dL, unsupported by transfusions (within days of study registration) Platelets >= x ^ cells/L (unsupported, defined as no platelet transfusion within days) Platelets >= , x ^/L, unsupported by transfusions Hemoglobin >= g/dL, unsupported by transfusions Absolute neutrophil count (ANC) >= x ^/L, unsupported by filgrastim (G-CSF) or granulocytes Within days of registration: Platelets >= ,/mcL unsupported by transfusions Platelets ? ,/mm (unsupported for days) Hemoglobin ? g/dl (unsupported) for days Platelets >= ,/mm^ (unsupported, defined as no platelet transfusion within days and recovery from nadir) Platelets >= ,/ul (unsupported) Hemoglobin (Hg) >= g/dL (unsupported) Absolute neutrophil count >= ,/mm^ (unsupported) Platelet count >= ,/mm^ (unsupported) Absolute neutrophil count >= ,/mm^ (unsupported) Platelet count >= ,/mm^ (unsupported) Adequate bone marrow function (hemoglobin ? . g/dL; unsupported platelets ? x cells/L; absolute neutrophil count ? .x cells/L Hemoglobin >= g/dL unsupported by transfusions within days RECURRENT/ PROGRESSIVE DIPG (STRATUM ): Platelets >= ,/mm^ (unsupported, defined as no platelet transfusion within days, and recovery from post-transfusion nadir) NON-PROGRESSED DIPG (STRATUM ): Platelets >= ,/ mm^ (unsupported, defined as no platelet transfusion within days, and recovery from post-transfusion nadir) Platelets >= ,/mm^ (unsupported) Hemoglobin >= g/dL (unsupported) Absolute neutrophil count (ANC) ? /?l and platelets ? /?l (unsupported by transfusions).