Participants with other active malignancy in the past years excluding in situ tumors Subject who has a history of second primary cancer within the past years, with the exception of: Past or present malignancy within the last years. History of malignancy other than MM within the past years Untreated and uncontrolled second tumor in the past years Untreated and uncontrolled second tumor in the past years History of malignancy other than B-NHL within the past years with the exception of: History of another malignancy within the past years (some skin cancer and prostate cancers permitted) History of other active malignancy within past years. Diverticulitis (either active or history of) within the past years; Note that diverticulosis is permitted Diverticulitis either active or history of within the past years; note that diverticulosis is permitted Untreated and uncontrolled second tumor in the past years Prior malignancy in past years or as identified in Section . of this protocol Prior chemotherapy within the past years Prior chemotherapy within the past years No malignancy (other than the one treated in this study) which required radiotherapy or systemic treatment within the past years Documented history of nephrolithiasis within the past years Patients with a past history of malignancy that were treated less than years and have not remained disease free for the past years. (Patients with non metastatic skin cancers will be eligible). Prior malignancy in past years or as identified in Section . of this protocol Subjects with active other malignancy diagnosed in the past years (excepting in situ tumors) Diagnosed with another malignancy within the past years History of other malignancy with the past years with some exceptions History of other malignancy within the past years with the following exceptions: Participants with a previous malignancy within the past years Subjects with history of other malignancy within past years (with exceptions) Diverticulitis (either active or history of) within the past years; note that diverticulosis is permitted Active malignancy of metastatic potential other than the known carcinoid or pancreatic NET within the past three years Second malignancy within the past years except: Any prior history of hematologic malignancy (other than CTCL) within past years Presence of malignancy (other than the one treated in this study) which required systemic treatment within the past years Patients who had radiation to greater than % marrow in the past years Any significant tobacco history within the past five years History of prior chemotherapy in the past years Diverticulitis (either active or history of) within the past years; note that diverticulosis is permitted Active treatment/chemotherapy for another primary malignancy within the past years No malignancy (other than for which patient underwent transplant) which required radiotherapy or systemic treatment within the past years Known active hyperparathyroid disease or other serious disturbance of calcium metabolism in the past years Diagnosed with another primary malignancy in the past years Patients with another malignancy within the past years History of ventricular tachyarrhythmia within the past years Other major cancer in the past years. History of second primary cancer within the past years, with the exception of: Second malignancy within the past years except: Patients diagnosed with hepatocellular carcinoma, or who have a history of biliary sepsis within the past years Known diagnosis of second malignancy within the past years Current or history of anorexia or bulimia in the past years Secondary cancer diagnosis (prior or current) within the past years Have completed cancer-related treatment within the past years Those who are in treatment or not in treatment, but who were diagnosed with breast cancer within the past years will be included Patients who are not current with CRC screening, defined as not having completed a home fecal occult blood test (FOBT) within the past year; a flexible sigmoidoscopy within the past years; or a colonoscopy within the past years Has not had one of the following CRC tests:\r\n* Fecal occult blood test within the past year\r\n* Flexible sigmoidoscopy within the past five years or\r\n* Colonoscopy within the past ten years Adherent to CRCS guidelines defined as a home-based fecal occult blood test (FOBT) in the past year, a sigmoidoscopy (SIG) in the past years, or a colonoscopy (COL) in the past years Patients who have received chemotherapy for a malignancy in the past years Diagnosis of cancer requiring systemic therapy in the past years Hospitalization due to a psychiatric disorder in the past years history of any other primary malignancy diagnosed within the past years Mammogram receipt within the past years Patient must not have another active (within past years) or concurrent malignancy Any other current or previous malignancy within the past years Patients with a malignancy within the past years for which study drugs or a prostatectomy is a contraindication Patient has an active malignancy of metastatic potential other than the known NE tumor for the past years History of a prior malignancy within past years are excluded unless they have been disease free for or more years Previous brachytherapy treatment will have occurred at least years in the past Known active hyperparathyroid disease or other serious disturbance of calcium metabolism in the past years Patients with electronic health record (EHR)-documented colonoscopy in the past years, sigmoidoscopy in the past years, or fecal occult blood test (FOBT) or fecal immunochemical test (FIT) in the past months will be excluded Criteria , History of other malignancy within the past years prior to enrollment with some exceptions, as outlined in the protocol. History of other malignancy within the past years