Patients must not be receiving any other anti-cancer agents or radiotherapy at the time of study entry or while on study. Last anti-cancer treatment within weeks prior to study entry Patient is NOT receiving any other anti-cancer agents or radiotherapy at the time of study entry Patients must not be receiving any other anti-cancer agents or radiotherapy at the time of study entry or while on study. Patients must not be receiving any other anti-cancer agents or radiotherapy at the time of study entry or while on study Patients must not be receiving any other anti-cancer agents or radiotherapy at the time of study entry or while on study No other investigational anti-tumor agents within days prior to study entry or during active participation in the study (defined as from study entry until tumor progression) Patients must not be receiving any other anti-cancer agents or radiotherapy at the time of study entry or while on study. Patients must not be receiving any other anti-cancer agents or radiotherapy at the time of study entry or while on study. Patients must not be receiving active anti-coagulation therapy at the time of study entry (or while on study). Patients must not be receiving anti-hypertensive medications at time of study entry. Treatment with any anti-cancer agents within days of study entry Treatment with any anti-cancer agents within days of study entry Participants may not be receiving any other study agents within days prior to entry on the study