Unwillingness or inability to comply with procedures required in this protocol Unwillingness to participate or inability to comply with the protocol for the duration of the study Unwillingness to undergo RPFNA Inability or unwillingness to give informed consent Unwillingness to accept the treatment; Unwillingness or inability to comply with procedures required in this protocol Unwillingness or inability to comply with procedures required in this protocol Unwillingness or inability to comply with the study protocol for any other reason Unwillingness or inability to comply with the study protocol for any other reason Unwillingness or inability to comply with the study protocol for any reason Inability or unwillingness to comply with radiation safety procedures or protocol requirements Inability or unwillingness to comply with radiation safety procedures or protocol requirements Inability or unwillingness to sign the informed consent form. Unwillingness to participate or inability to comply with the protocol for the duration of the study Inability or unwillingness to tolerate endocrine therapy Inability or unwillingness to have pleural catheter placed Subject has an inability or unwillingness, in the opinion of the investigator, to comply with the protocol requirements Unwillingness to give written informed consent, unwillingness to participate, or inability to comply with the protocol for the duration of the study Unwillingness or inability to comply with protocol. Unwillingness or inability to comply with procedures required in this protocol. Unwillingness or inability to comply with the protocol Unwillingness to participate or inability to comply with the protocol for the duration of the study Unwillingness or inability to provide written informed consent and comply with the study protocol for any reason Inability or unwillingness to comply with birth control requirements or regional REMS/RevAid programs Unwillingness to give written informed consent, unwillingness to participate, or inability to comply with the protocol for the duration of the study Inability or unwillingness to receive antithrombotic therapy Unwillingness or inability to receive conventional chemotherapy Unwillingness or inability to comply with the protocol Unwillingness to participate or inability to comply with the protocol for the duration of the study Unwillingness or inability to comply with protocol. Unwillingness to participate or inability to comply with the protocol for the duration of the study Is unwilling to give written informed consent, unwillingness to participate, or inability to comply with the protocol for the duration of the study Inability or unwillingness to comply with the treatment protocol, follow-up, or research tests Unwillingness or inability to comply with the protocol Unwillingness or inability to comply with the study protocol for any reason. Unwillingness to participate or inability to comply with the protocol for the duration of the study Unwillingness or inability to comply with procedures required in this protocol. Unwillingness or inability to comply with procedures required in this protocol Unwillingness or inability to comply with mandated blood draws. Inability or unwillingness of individual to give written informed consent Inability or unwillingness to give informed consent Inability or unwillingness of individual to give written informed consent Unwillingness to comply with the requirements of the protocol Inability or unwillingness to abstain from non-protocol use of aspirin or NSAIDs or to provide blood, urine, or stool samples or colon biopsies during the study Unwillingness or inability to participate or give informed consent Inability or unwillingness to provide informed consent to the study Inability or unwillingness to undergo PET scanning Inability or unwillingness to cooperate with requirements of this trial Inability or unwillingness to undergo the complete series of imaging sessions; inability or unwillingness to complete the one month follow-up Unwillingness or inability to give informed consent Unwillingness to engage in adequate contraception