Participants with any of the following:\r\n* History of myocardial infarction within six months\r\n* Unstable angina\r\n* History of cerebrovascular accident (CVA) within  months\r\n* New York Heart Association grade II or greater congestive heart failure\r\n* Significant vascular disease (e.g. aortic aneurysm, history of aortic dissection)\r\n* Clinically significant peripheral vascular disease
Significant vascular disease (e.g., aortic aneurysm, aortic dissection, symptomatic peripheral vascular disease)
Clinically significant peripheral vascular disease or vascular disease (abdominal aortic aneurysm >  cm) or aortic dissection; if known history of abdominal aortic aneurysm with >=  cm in diameter, all of the following must be met\r\n* An ultrasound within the last  months required to document that it is =<  cm\r\n* Patient must be asymptomatic from the aneurysm\r\n* Blood pressure must be well controlled as defined in this protocol
Significant known vascular disease (e.g. aortic aneurysm, aortic dissection)
Uncontrolled intercurrent illness including, but not limited to, severe or unstable angina, myocardial infarction, symptomatic congestive heart failure (defined as New York Heart Association grade II or greater), arterial or venous thromboembolic events (e.g., pulmonary embolism), or clinically significant ventricular arrhythmias, significant vascular disease (e.g. aortic aneurysm, aortic dissection), or symptomatic peripheral vascular disease within  months prior to registration
Significant vascular disease (e.g., aortic aneurysm, aortic dissection, symptomatic peripheral vascular disease including claudication, Leo Buerger's disease). Treated peripheral vascular disease that is stable for at least  months is allowed.
History of cardiac or aortic surgery,
Known cardiac valvular disease (e.g. bicuspid aortic valve) or arterial aneurysm(s) that may allow a nidus of infection.
Clinically significant peripheral vascular disease or known abdominal aortic aneurysm ( >  cm in diameter) or history of aortic dissection; patients with known history of abdominal aortic aneurysm (AAA) with >=  cm in diameter, a repeat ultrasound (US) within the last  months prior to randomization will be required to document that it is =<  cm, and patient must be asymptomatic from the aneurysm, and the blood pressure must be well controlled as required in this protocol
Clinically significant peripheral vascular disease or abdominal aortic aneurysm (>  cm) or aortic dissection; if known history of abdominal aortic aneurysm with >=  cm in diameter, all of the following must be met: \r\n* An ultrasound (US) within the last  months prior to registration will be required to document that it is =<  cm\r\n* Patient must be asymptomatic from the aneurysm\r\n* Blood pressure must be well controlled as defined in this protocol
PHASE I STUDY ELIGIBILITY CRITERIA:\r\nPatients who have the following clinical conditions are considered to be at increased risk for cardiac toxicities; patients with any cardiac history of the following conditions within  year prior to MEDI+O study or within  years prior to MEDI+C or MEDI+O+C enrollment are excluded from the study:\r\n* Prior events including myocardial infarction, clinically significant pericardial effusion, and myocarditis\r\n* Prior cardiac arrhythmia including atrial fibrillation and atrial flutter, or requiring concurrent use of drugs or biologics with pro-arrhythmic potential\r\n* New York Heart Association (NYHA) class II or greater heart failure\r\n* If cardiac function assessment is clinically indicated or performed, an left ventricular ejection fraction (LVEF) less than normal per institutional guidelines, or < %, if threshold for normal is not otherwise specified by institutional guidelines\r\n* Mean QT interval corrected for heart rate (QTc) >=  ms calculated from  electrocardiograms (ECGs) using Fridericias correction or other significant ECG abnormality noted within  days of treatment\r\n* Hypertensive crisis or hypertensive encephalopathy\r\n* Clinically significant peripheral vascular disease or vascular disease, including rapidly growing aortic aneurysm or abdominal aortic aneurysm >  cm or aortic dissection\r\n* Unstable angina
PHASE II STUDY COHORT  OVARIAN CANCER ELIGIBILITY CRITERIA (MEDI+O, MEDI+C AND MEDI+O+C):\r\nPatients with any cardiac history of the following conditions within  year prior to MEDI+O arm or within  years prior to MEDI+C or MEDI+O+C arm enrollment are excluded from the study:\r\n Prior events including myocardial infarction, clinically significant pericardial effusion, and myocarditis\r\n Prior cardiac arrhythmia including atrial fibrillation (except chronic atrial fibrillation with controlled vascular rate), and atrial flutter, or requiring concurrent use of drugs or biologics with pro-arrhythmic potential\r\n NYHA class II or greater heart failure\r\n If cardiac function assessment is clinically indicated or performed, an LVEF less than normal per institutional guidelines, or < %, if threshold for normal is not otherwise specified by institutional guidelines\r\n Mean QT interval corrected for heart rate (QTc) >=  ms calculated from  (ECGs) using Fridericias correction or other significant ECG abnormality noted within  days of treatment\r\n Hypertensive crisis or hypertensive encephalopathy\r\n Clinically significant peripheral vascular disease or vascular disease, including rapidly growing aortic aneurysm or abdominal aortic aneurysm >  cm or aortic dissection\r\n Unstable angina
PHASE II STUDY COHORT  TRIPLE NEGATIVE BREAST CANCER ELIGIBILITY CRITERIA (MEDI+O ONLY):\r\nPatients with any cardiac history of the following conditions within  year prior to study enrollment are excluded from the study:\r\n* Prior events including myocardial infarction, clinically significant pericardial effusion, and myocarditis\r\n* Prior cardiac arrhythmia including atrial fibrillation (except chronic atrial fibrillation with controlled vascular rate) and atrial flutter, or requiring concurrent use of drugs or biologics with pro-arrhythmic potential\r\n* NYHA class II or greater heart failure\r\n* If cardiac function assessment is clinically indicated or performed, an LVEF less than normal per institutional guidelines, or < %, if threshold for normal is not otherwise specified by institutional guidelines\r\n* Mean QT interval corrected for heart rate (QTc) >=  ms calculated from  electrocardiograms (ECGs) using Fridericias correction or other significant ECG abnormality noted within  days of treatment\r\n* Clinically significant peripheral vascular disease or vascular disease, including rapidly growing aortic aneurysm or abdominal aortic aneurysm >  cm or aortic dissection\r\n* Unstable angina
PHASE II STUDY NON-SMALL CELL LUNG CANCER (COHORT ; MEDI+O AND MEDI+C) AND SMALL CELL LUNG CANCER (COHORT ; MEDI+O ONLY) ELIGIBILITY CRITERIA:\r\nPatients with any cardiac history of the following conditions within  year prior to MEDI+O study or within  years prior to MEDI+C study enrollment are excluded from the study:\r\n* Prior events including myocardial infarction, clinically significant pericardial effusion, and myocarditis\r\n* Prior cardiac arrhythmia including atrial fibrillation (except chronic atrial fibrillation with controlled vascular rate) and atrial flutter, or requiring concurrent use of drugs or biologics with pro-arrhythmic potential\r\n* NYHA class II or greater heart failure\r\n* If cardiac function assessment is clinically indicated or performed, an LVEF less than normal per institutional guidelines, or < %, if threshold for normal is not otherwise specified by institutional guidelines\r\n* Mean QT interval corrected for heart rate (QTc) >=  ms calculated from  electrocardiograms (ECGs) using Fridericias correction or other significant ECG abnormality noted within  days of treatment\r\n* Hypertensive crisis or hypertensive encephalopathy\r\n* Clinically significant peripheral vascular disease or vascular disease, including rapidly growing aortic aneurysm or abdominal aortic aneurysm >  cm or aortic dissection\r\n* Unstable angina
PHASE II COLORECTAL CANCER COHORT  (MEDI+C ONLY):\r\nPatients with any cardiac history of the following conditions within  years prior to study enrollment are excluded from the study:\r\n* Prior events including myocardial infarction, clinically significant pericardial effusion, and myocarditis\r\n* Prior cardiac arrhythmia including atrial fibrillation and atrial flutter, or requiring concurrent use of drugs or biologics with pro-arrhythmic potential\r\n* NYHA Class II or greater heart failure\r\n* If cardiac function assessment is clinically indicated or performed, an LVEF less than normal per institutional guidelines, or < %, if threshold for normal is not otherwise specified by institutional guidelines\r\n* Mean QT interval corrected for heart rate (QTc) >=  ms calculated from  electrocardiograms (ECGs) using Fridericias correction or other significant ECG abnormality noted within  days of treatment\r\n* Hypertensive crisis or hypertensive encephalopathy\r\n* Clinically significant peripheral vascular disease or vascular disease, including rapidly growing aortic aneurysm or abdominal aortic aneurysm >  cm or aortic dissection\r\n* Unstable angina
Clinically significant peripheral vascular disease or vascular disease (including aortic aneurysm or aortic dissection)
Significant valvular disease; (aortic stenosis [AS] with aortic valve area [AVA] < . and severe aortic regurgitation [AR] and mitral regurgitation [MR])
Significant vascular disease (e.g., aortic aneurysm, aortic dissection)
Significant vascular disease (e.g., aortic aneurysm, aortic dissection) or recent peripheral arterial thrombosis within  months prior to day 
Significant valvular disease; (aortic stenosis [AS] with aortic valve area [AVA] < . and severe aortic regurgitation [AR] and mitral regurgitation [MR])
Clinical significant peripheral vascular disease or vascular disease (aortic aneurysm or aortic dissection)
Significant vascular disease (e.g., aortic aneurysm, aortic dissection)
Patients are excluded if they have known significant vascular disease (e.g., aortic aneurysm, aortic dissection)
Significant vascular disease (e.g., aortic aneurysm, history of aortic dissection) or clinically significant peripheral vascular disease
Any other significant vascular disease (e.g., aortic aneurysm, aortic dissection, or carotid stenosis that requires medical or surgical intervention, including angioplasty or stenting)
Participants should not have clinically significant peripheral vascular disease or vascular disease (including aortic aneurysm or aortic dissection)
History of aortic aneurysm, aortic dissection, angina, myocardial infarction, stroke, transient ischemic attack, or other arterial thrombotic events within  months of registration; patients on therapeutic non-coumarin anticoagulation are eligible provided that they are on a stable dose of anticoagulants
No history of significant vascular disease (eg aortic aneurysm)
Significant vascular disease including aortic aneurysm, aortic dissection
Clinical significant peripheral vascular disease or vascular disease (aortic aneurysm or aortic dissection)
Significant vascular disease (e.g., aortic aneurysm, history of aortic dissection)
Symptomatic aortic stenosis or syncope in the last week
symptomatic severe aortic stenosis,