Women of childbearing potential must have a negative serum or urine pregnancy test at screening Negative pregnancy test at the Screening visit for women of childbearing potential and willingness to use adequate birth control If the participant is of childbearing potential, she must have a documented negative urine pregnancy test at the time of screening and randomization and no plans to become pregnant for the duration of study participation. Women of childbearing potential must have a negative urine pregnancy test at the screening visit Patients who are pregnant or nursing; women of childbearing potential (WOCBP) will have to undergo a urine pregnancy test as part of screening Pregnancy, lactation, or breast-feeding; women of childbearing potential must have a negative urine pregnancy test at screening Women of childbearing potential must have a negative urine or serum pregnancy test at screening within days prior to randomization Negative serum or urine pregnancy test at screening for women of childbearing potential Patients who are pregnant or breastfeeding, or expecting to conceive or father children within the projected timeframe of the study, starting from the time of the Screening Visit through months ( days) after the last OBP- administration. Females of childbearing potential must have a negative serum pregnancy test at Screening and a negative urine pregnancy test at each visit before administration of OPB-. A female not of childbearing potential is one who has undergone bilateral oophorectomy or who has had no menses for consecutive months. Negative serum pregnancy test at screening for women of childbearing potential Negative serum pregnancy test at screening for women of childbearing potential Negative serum pregnancy test at screening for women of childbearing potential All women of childbearing potential must have a negative urine or serum pregnancy test at screening. A negative serum pregnancy test at screening for women of childbearing potential (WOCBP) Women of childbearing potential must have a negative blood pregnancy test at the screening visit Women of childbearing potential who have a positive result on screening urine pregnancy test Women of childbearing potential must have a pregnancy test at screening Negative blood pregnancy test at Screening for women of childbearing potential Negative blood pregnancy test at the screening visit for women of childbearing potential Women of childbearing potential must have a negative serum or urine pregnancy test at Screening Women of childbearing potential must have a negative serum or urine pregnancy test at screening Pregnant or lactating women; women of childbearing potential must have a negative pregnancy test at screening Women of childbearing potential must have negative blood or urine pregnancy test at screening Pregnant or lactating women; women of childbearing potential must have a negative pregnancy test at screening Women of childbearing potential must have a pregnancy test at screening For women of childbearing potential (WOCBP), a negative serum pregnancy test result at Screening. Pregnant or lactating women; women of childbearing potential must have a negative pregnancy test at screening Patients who are pregnant or nursing; women of childbearing potential (WOCBP) will have to undergo a urine pregnancy test as part of screening Women of childbearing potential must have a negative serum or urine pregnancy test at the Screening Visit and be non-lactating. Women of childbearing potential must have a negative serum pregnancy test at the screening visit. For women of childbearing potential, the participant must have a negative pregnancy test at screening and must agree to employ forms of adequate contraceptive measures Women of childbearing potential must have a negative urine pregnancy test at screening, and Females who are pregnant or breast feeding at the time of screening will not be eligible for this study; a urine pregnancy test will be performed in women of childbearing potential at screening Women of childbearing potential who refuse a pregnancy test Women of childbearing potential who refuse a pregnancy test (performed during screening) Women of childbearing potential will undergo a pregnancy test Women of childbearing age must have a negative pregnancy test at screening/baseline Negative serum pregnancy test at screening for women of childbearing potential