Current evidence of clinically significant corneal or retinal disorder confirmed by ophthalmologic examination.
Corneal defects, corneal ulcerations, keratitis, keratoconus, history of corneal transplant, or other known abnormalities of the cornea that may pose an increased risk of developing a corneal ulcer
Active or chronic corneal disorder, including but not limited to the following: Sjogren's syndrome, Fuchs corneal dystrophy (requiring treatment), history of corneal transplantation, active herpetic keratitis, and also active ocular conditions requiring on-going treatment/monitoring such as wet age-related macular degeneration requiring intravitreal injections, active diabetic retinopathy with macular edema, presence of papilledema, and acquired monocular vision
Active or chronic corneal disorder, including but not limited to the following: Sjogrens syndrome, Fuchs corneal dystrophy (requiring treatment), history of corneal transplantation, active herpetic keratitis, and also active ocular conditions requiring on-going treatment/monitoring such as wet age-related macular degeneration requiring intravitreal injections, active diabetic retinopathy with macular edema, presence of papilledema, acquired monocular vision, and any preexisting active conjunctival disease
Grade >=  blurred vision, conjunctivitis, corneal ulcer, dry eye, or keratitis
History of confirmed, corneal ulceration
Has clinically significant corneal disease
Corneal or retinal abnormality likely to increase the risk of eye toxicity
Active infection or corneal ulcer (e.g. keratitis)
History of corneal transplantation
Active or chronic corneal disorder, history of corneal transplantation, active herpetic keratitis, and active ocular conditions requiring ongoing treatment/monitoring
Corneal disease, such as bullous or band keratopathy, corneal desquamation, keratitis, corneal ulcer, or keratoconjunctivitis
Any corneal or retinal abnormality likely to increase the risk of eye toxicity, such as:\r\n* Current corneal pathology such as keratitis, keratoconjunctivitis, keratopathy, corneal abrasion, inflammation or ulceration\r\n* Uncontrolled glaucoma despite standard of care therapy\r\n* Diabetic retinopathy with macular edema\r\n* Known active wet, age-related macular degeneration (AMD)\r\n* Known central serous retinopathy (CSR) or retinal vascular occlusion (RVO)
Active keratitis or current corneal disorder.
Patients who are known to have a history of or a finding of corneal epitheliopathy at pre-study are excluded
Active or chronic corneal disorder, including but not limited to the following: Sjogrens syndrome, Fuchs corneal dystrophy (requiring treatment), history of corneal transplantation, active herpetic keratitis, and also active ocular conditions requiring on-going treatment/monitoring such as wet age-related macular degeneration requiring intravitreal injections, active diabetic retinopathy with macular edema, presence of papilledema, and acquired monocular vision
PRE-SCREENING: No history of keratitis or corneal disease
Patients with corneal epitheliopathy or any eye disorder that may predispose the patients to this condition at the discretion of the ophthalmologist
Active infection or corneal ulcer
History of corneal transplantation
Current evidence of corneal or retinal disorder/keratopathy including, but not limited to, bullous/band keratopathy, corneal abrasion, inflammation/ulceration, keratoconjuctivitis, confirmed by ophthalmologic examination
Current evidence of corneal or retinal disorder/keratopathy including, but not limited to, bullous/band keratopathy, corneal abrasion, inflammation/ulceration, and/or keratoconjunctivitis, confirmed by ophthalmologic examination
Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition
Has clinically significant corneal disease
Current corneal epithelial disease except mild punctate keratopathy.
Current corneal disease except for mild punctuate keratopathy.
Current corneal disease except for mild punctuate keratopathy.
Patients with corneal epitheliopathy or any eye disorder that may predispose the patients to this condition as judged by an ophthalmologist\r\n* Note: Low grades of superficial punctate keratitis, within the range seen in the normal population, should not lead to the exclusion of the patient
Subjects with corneal epitheliopathy or any eye disorder that may predispose the subjects to drug-induced corneal epitheliopathy, or may interfere with diagnosis of treatment-emergent corneal epitheliopathy at the discretion of the investigator in consultation with the ophthalmologist/optometrist; low grades of superficial punctate keratitis, within the range seen in the normal population, should not lead to the exclusion of the patient
Corneal defects, corneal ulcerations, keratitis, keratoconus, history of corneal transplant, or other known abnormalities of the cornea
Active infection or corneal ulcer (e.g., keratitis)
History of corneal transplantation
Current evidence of corneal disorder/ keratopathy incl. but not limited to bullous/ band keratopathy, corneal abrasion, inflammation/ulceration, keratoconjunctivitis etc., confirmed by ophthalmologic examination.
Know history of allografts (including corneal transplant).
Corneal epitheliopathy or any eye disorder that may predispose the subjects to drug-induced corneal epitheliopathy, or may interfere with diagnosis of treatment-emergent corneal epitheliopathy at the ophthalmologist's or the investigator's discretion
Active corneal disorder or keratopathy (e.g. corneal abrasion, bullous keratopathy)
Concurrent corneal disorder or ophthalmologic condition making subject unsuitable
Current evidence of corneal disorder/keratopathy
Patients with corneal epitheliopathy or any eye disorder that may predispose the patients to this condition at the discretion of the investigator in consultation with the ophthalmologist.
Any active or chronic corneal disorder and Sjogren's syndrome.
Current evidence of corneal or retinal disorder, including but not limited to bullous/band keratopathy, keratoconjunctivitis, corneal abrasion, inflammation/ulceration, confirmed by ophthalmologic examination
Current evidence of corneal disorder/keratopathy, including but not limited to bullous/band keratopathy, corneal abrasion, inflammation/ulceration, and keratoconjunctivitis, as confirmed by ophthalmologic examination.
Corneal pathology that would limit evaluation of loss in visual acuity associated with corneal deposits.
Patient with any active or chronic corneal disorders
History of corneal disease
Active corneal erosions or history of abnormal corneal sensitivity test
Active or chronic corneal disorder, including but not limited to the following:\r\n* Sjogrens syndrome\r\n* Fuchs corneal dystrophy (requiring treatment)\r\n* History of corneal transplantation\r\n* Active herpetic keratitis\r\n* Active ocular conditions requiring on-going treatment/monitoring such as wet age-related macular degeneration requiring intravitreal injections, active diabetic retinopathy with macular edema, presence of papilledema, and acquired monocular vision
Have preexisting corneal disease that may interfere with assessment for potential eye toxicity during the study.
Current evidence of corneal or retinal disorder/keratopathy including but not limited to bullous/band keratopathy, corneal abrasion, inflammation/ulceration, keratoconjunctivitis, confirmed by ophthalmologic examination
Current corneal disease or a history of corneal disease.
Has clinically significant corneal disease
Current evidence of corneal disorder/keratopathy including but not limited to bullous/band keratopathy, corneal abrasion, inflammation/ulceration, or keratoconjunctivitis