Platelet count >= ,/mL within days prior to registration STEP I: Untransfused platelet count >= , cells/mm^ (obtained within days prior to randomization) Platelet count >= ,/ mL within days prior to registration; patients must not have had a blood transfusion within days prior to registration Platelet count >= , mcl obtained within days prior to sub-study registration Platelet count >= ,/mcL; must be obtained within days prior to registration Within days of registration: Platelet count >= ,/mm^ Obtained within days prior randomization: platelet count must be >= ,/mm^ Platelet (PLTs) count >= ,/mm^ obtained =< days prior to registration Platelet count >= ,/ mm^ (=< days prior to registration) Obtained =< days prior to registration: Platelet count >= ,/mm^ Obtained within days prior to registration: Platelet count >= x ^/L Platelet count >= x ^/L performed within days prior to the date of registration Obtained =< days prior to registration: platelet count >= ,/mm^ Platelet count >= ,/mm^, obtained =< days prior to registration Platelet count >= x ^/L (obtained =< days prior to registration) Platelet count >= ,/mm^ =< days prior to registration Obtained =< days prior to registration: Platelet count >= /mm^ Obtained ? days prior to registration: Platelet count ? /mm^; Note: Platelet transfusion is not allowed ? days prior to registration Platelet count >= , / ml obtained =< days prior to study initiation Obtained within days prior to cycle , day : platelet count >= ,/mm Platelet count ? ,/mm^ ( ^/L) obtained ? days prior to randomization Platelet count >= ,/mm^ obtained =< days prior to registration Obtained =< days prior to registration: Platelet count >= ,/mm^ Obtained =< days prior to registration: Platelet count >= ,/mm^ Obtained =< days prior to registration: Platelet count >= x ^/L unless the participant has >= % bone marrow infiltration in which case a platelet count of >= x ^/L is allowed Obtained =< days prior to registration: Platelet count >= ,/mm^ Within days prior to registration: Platelet count >= x ^/L Platelet count >= ,/mm^ obtained =< days prior to registration Platelet count >= ,/mm^ obtained =< days prior to registration Platelet count >= ,/mm^ (obtained =< days prior to registration)\r\n* Criteria must be met without a transfusion within four weeks of registration Platelet count >= x ^/L (>= , per mm^) within days prior to study registration Untransfused platelet count >= /mm^, obtained =< days prior to registration Obtained =< days prior to registration: Platelet count >= ,/mm^ Platelet count >= ,/mm^ obtained =< days prior to registration Within days prior to registration, hematologic minimal values: platelet count > ,/mm^ Obtained =< days prior to randomization: Platelet count >= ,/mm^ Obtained =< days prior to registration: Platelet count >= ,/mm^ Platelet count >= ,/mm^, obtained =< days prior to registration Platelet count >= ,/ucl obtained within days prior to registration Patients must have an ANC ? ,/?l and a platelet count ? ,/?l obtained within days prior to registration. Platelet count of >= x ^/L (performed within days prior to registration) Platelet count >= ,/mm^ obtained =< days prior to registration Obtained =< days prior to randomization: \r\nPlatelet count >= ,/mm^ Platelet count >= ,/mm^ obtained =< days prior to registration Platelet count >= /mm^, obtained =< days prior to registration Platelet count >= , /mm^ within days prior to registration. Obtained =< days prior to registration: Platelet count >= ,/mm^ Within days prior to registration: Platelet count >= x ^/L Platelet count >= ,/mm^ ( x ^ /L) obtained =< days prior to registration Platelet count >= ,/mm^, obtained =< days prior to registration ARM A: obtained =< days prior to registration: \r\n* Platelet count >= ,/mm^ ARM B: obtained =< days prior to registration: \r\n* Platelet count >= ,/mm^ Platelet count >= ,/mm^ or >= x ^/L (must be >= days after most recent transfusion), obtained =< days prior to registration Obtained within days prior to registration: Platelet > k Obtained =< days prior to registration: Platelet count >= ,/mm^ Platelet count >= , mcl obtained within days prior to Step re-registration Platelet count >= ,/mm^ (obtained =< days prior to registration) Platelet count >= , mcl obtained within days prior to Step re-registration Platelet count >= , mcl obtained within days prior to step re-registration CLINICAL/LABORATORY CRITERIA: Platelet count >= ,/mcL; these results must be obtained within days prior to registration Platelet count >= ,/mcL obtained within days prior to registration Platelet count >= , mcl obtained within days prior to RE-TREATMENT registration Platelet count >= ,/mm^, obtained =< days prior to registration Platelet count >= ,/mm^ obtained =< days prior to registration Platelet >= x ^/L (> , per mm^), obtained within days prior to first treatment Platelet count > x ^/L (within days prior to registration); or Platelet count >= ,/mm^ obtained =< days prior to registration Platelet count > ,/mm^ (obtained =< days prior to randomization) Platelet count >= ,/mm^ obtained =< days prior to randomization Obtained within weeks from study entry: Platelet count >= ,/mm^ Platelet count >= ,/mm^ obtained =< days prior to randomization Untransfused platelet count >= /mL (obtained =< days prior to registration) Platelet >= x ^/L (> , per mm^), obtained within days prior to first treatment Platelet count of >= ,/microliters within days prior to registration Obtained =< days prior to randomization: Platelet count >= ,/mm^ Platelet count >= ,/mm^ obtained =< days prior to registration Platelet count >= ,/microliter obtained =< days prior to randomization In patients who will receive bortezomib for imaging purposes only:\r\n* Total bilirubin < . x upper limit of normal obtained within weeks prior to registration\r\n* Platelet count >= ,/mm^ obtained within weeks prior to registration\r\n* No pre-existing peripheral neuropathy greater than grade Platelet count of >= ,/mm^, performed within days prior to registration