Re-registration: ANC >= ,/mm^ ANC ? /mm Must have measurable MM Prior treatment with MM- Measurable (>mm x mm) contrast enhancing disease. ANC must be ? /mm; ANC >/mm. ANC >/= /mm, Cohort (PTCL): ANC >/= /mm ANC* ? /mm (? . x ^/L) Adequate bone marrow function: white blood cells (WBCs) ? ,/mm, absolute neutrophil count (ANC) ? ,/mm, hemoglobin ? g/dL, and platelets ? ,/mm Adequate hematology without ongoing transfusional support (hemoglobin > g/dL, ANC > , per mm, platelets > , per mm). Absolute neutrophil count (ANC) >= /mm^; (ANC > /mm^ may be considered in special circumstances such as benign cyclical neutropenia as judged by the investigator and in discussion with the sponsor) Absolute neutrophil count (ANC) >= . K/cu mm; for subjects with ANC < . K/cu mm due to significant marrow involvement by MCL, ANC must be > . K/cu mm Adequate hematologic function (Platelets ? ,/mm, lymphocytes ? ,/mm, neutrophils ? /mm, hemoglobin ? g/dl). Adequate hematological function, defined as ANC ? ,/mm, Hb ? . g/dL, and platelet count ? ,/mm. ANC ?,/mm^ (?.x^/L) Evidence of MM disease progression any time prior to enrollment; progression from smoldering/asymptomatic MM to symptomatic MM is not exclusionary An absolute neutrophil count (ANC) > ,/mm^ (patients who have bone marrow infiltration by MCL are eligible if their ANC is >= /mm^ [growth factor allowed]; these patients should be discussed with either the principal investigator [PI] or Co-PI of the study for final approval) Platelets >= ,/mm^ or >= ,/mm^ in the setting of marrow involvement by disease or splenomegaly due to disease Relapsed/refractory MCL: Absolute neutrophil count (ANC) >= /mm^; (patients who have bone marrow infiltration by MCL are eligible if their ANC is >= /mm^ [growth factor allowed]; these patients should be discussed with either the principal investigator [PI] or Co-PI of the study for final approval) Hematopoietic Function: WBC ? ,/mm; ANC ? /mm; Hemoglobin ? g/dL; Platelet count ? ,/mm; Coagulation: INR ? .. Adequate hematologic function (Platelets ? ,/mm, lymphocytes ? , mm, neutrophils ? /mm, hemoglobin ? . g/dl). Adequate hematologic reserve obtained ? weeks prior to entry: leukocytes ? , mm^; absolute neutrophil count ? mm^; platelets ? , mm^ Adequate hematology without ongoing transfusional support (hemoglobin > g/dL, ANC > , per mm, platelets > , per mm). ANC > /mm, plt count > ,/mm Has MM positive for t(;). Adequate hematology without ongoing transfusional support (hemoglobin > g/dL, ANC ? , per mm, platelets > , per mm) Patients must have adequate hematologic reserve as evidenced by absolute neutrophil count (ANC) >= /mm^ and platelets >= ,/mm^ ANC ?,/mm^ (?. x ^/L) Marrow: Peripheral blood leukocyte count (WBC) < /mm, absolute neutrophil count ? /mm, platelets < /mm, or hemoglobin < gm/dL MM diagnostic criteria (all required); ABC count ? ,/mm Marrow: Peripheral blood leukocyte count (WBC) < /mm, absolute neutrophils count ? /mm, platelets < /mm, or hemoglobin < gm/dL. ANC: for patients with lymphoma ?/mm (?. ^/L), for patients with advanced solid tumors ?,/mm (?. ^/L), ANC ? , / mm Marrow: Peripheral blood leukocyte count (WBC) < /mm, absolute neutrophil count ? /mm, platelets < /mm, or hemoglobin < gm/dL Marrow: Hemoglobin >= . g/dL, absolute neutrophil count (ANC) >=,/mm, and platelets >=,/mm. Platelet count > ,/mm^; (patients who have bone marrow infiltration by MCL are eligible if their ANC is >= /mm^ [growth factor not allowed] or their platelet level is >= ,/mm^) Absolute neutrophil count (ANC) > ,/mm^; (patients who have bone marrow infiltration by MCL are eligible if their ANC is >= /mm^ [growth factor not allowed] or their platelet level is >= ,/mm^) PHASE II: Alternatively, with less BM involvement, an ANC >= /mm^, and platelet count >= , mm^ is required Hb concentration <. mmol/L (<. g/dL); WBC = ,/mm^ Absolute neutrophil count (ANC) > ,/mm^; (patients who have bone marrow infiltration by MCL are eligible if their ANC is /mm^ [growth factor allowed] or their platelet level is equal to or > than ,/mm^) ANC ?/mm Patients should have adequate bone marrow function defined as a peripheral WBC >,/mm with an ANC >/mm and a platelet count >,/mm. Adequate hematologic function including ANC ? /mm, Hemoglobin ? g/dL (transfusion is permitted), and platelets ? ,/mm. Patients with nodal disease limited to micrometastases (pNMi, > . mm and =< mm) or isolated tumor cells (pNi+ < . mm) ANC of >/mm ANC of >/mm independent of G-CSF ANC of >/mm independent of G-CSF MM diagnostic criteria (all required): Smoldering MM. Smoldering MM. Has a single lesion with a maximum size of ? mm with ? mm of capsular contact as confirmed by MR imaging, Have had at least one prior episode of fever and neutropenia (ANC < /mm^ or expected to fall below < /mm^) during doxorubicin and cyclophosphamide (AC) No metastatic sites >= mm ANC ? /mm At least mm of tumor on biopsy (can have multiple cores to comprise mm) ANC ? mm, platelets ? ,/mm, hemoglobin ? g/dL,