PT ? . times institutional ULN Coagulation: PT > seconds more than ULN or INR > . PT/INR ? ULN within days of randomization. Patients receiving therapeutic anti-coagulants are not eligible. For participants who have not received prior neoadjuvant chemotherapy: tumor stage of pT-a or pN+ (pT- or pN+ for participants with upper urinary tract UC) and M Has received prior treatment with PT or another HIF-? inhibitor Intermediate-high risk RCC: pT, Grade or sarcomatoid, N, M; pT, Any Grade, N, M High risk RCC: pT, Any Grade N, M; pT, Any stage, Any Grade, N+, M Patient (Pt) may be excluded if, in the opinion of the principal investigator (PI) and investigator team, the pt is not capable of being compliant Pt may be excluded if, in the opinion of the principal investigator (PI) and investigator team, the pt is not capable of being compliant IMMUNE RECONSTITUTION STUDY ONLY: Received haploidentical BMT with the current standard of two days of PT-CY (and no PT-BEN) Patient (Pt) may be excluded if, in the opinion of the principal investigator (PI) and investigator team, the pt is not capable of being compliant PT ?. ULN PT <. ULN One of the following pathologic T-classifications: pT or pT\r\n* Patients with positive surgical margins are eligible pT, G any, N; or, pT, G any, N; or, pT any, G any, N or M) Normal PT or INR and aPTT PT/aPIT ? . x ULN PT/INR and aPTT ? . ULN. PT or aPTT < . times the ULN Patients with pT or pT disease