Patients must have histologically or cytologically documented adenocarcinoma of the colon or rectum that is metastatic or locally advanced and unresectable
Histologically proven stage III colon adenocarcinoma (any T [Tx, T, T, T, or T], N-M; includes NC); tumors must be deemed to originate in the colon including tumors that extend into/involve the small bowel (e.g. those at the ileocecal valve)
Entire tumor must be in the colon (rectal involvement is an exclusion); surgeon confirmation that entire tumor was located in the colon is required only in cases where it is important to establish if the tumor is a colon versus (vs.) rectal primary
Based upon the operative report and other source documentation, the location of the primary tumor will be categorized as proximal or distal to the splenic flexure (distal includes), and further categorization will be as follows: cecum/ascending, descending, sigmoid colon, or rectosigmoid colon
Diagnosis of metastatic adenocarcinoma of colon or rectum without previous chemotherapy or any other systemic therapy for metastatic colorectal cancer
Participants must have histologically or cytologically confirmed adenocarcinoma of the colon or rectum
For Part B dose confirmation: All participants must have histological evidence of advanced or metastatic colon cancer or soft tissue sarcoma. Colon cancer participants must have prescreened mutations, amplification, or gene/protein expression alterations related to Notch pathway.
Neuroendocrine Tumors (well- and moderately-differentiated) of the lung, appendix, small intestine, colon, rectum, or pancreas
Patients must have histologically or cytologically confirmed metastatic or unresectable adenocarcinoma of the colon or rectum
Histologically or cytologically confirmed adenocarcinoma of the colon or the rectum that is metastatic or unresectable.
The primary tumor in the colon or rectum may be intact or resected
Histologically confirmed diagnosis of colon or rectal adenocarcinoma of any clinical stage, previously untreated with chemotherapy or radiotherapy, with a plan to undergo surgical resection no sooner than  days from the projected date of study drug initiation
Have histologically proven adenocarcinoma of the colon or rectum
Patients with a ?mm non-pedunculated colon polyp
Histological or cytological documentation of adenocarcinoma of the colon or rectum
Cancer of pancreas, colon or rectum
On primary diagnosis, patients must have had histologically confirmed adenocarcinoma of the colon or rectum; metastasis or recurrence do not need to be histologically confirmed
Histologically documented adenocarcinoma (including the histologic variants of adenocarcinoma) of the colon or rectum
Histologically or cytologically proven adenocarcinoma of the colon or rectum
Histologically confirmed inoperable advanced adenocarcinoma of the colon or rectum
Histologically confirmed inoperable advanced adenocarcinoma of the colon or rectum
Histologically documented adenocarcinoma of the colon; the gross inferior (caudad) margin of the primary tumor must lie above the peritoneal reflection (i.e., patients with rectal cancer are not eligible); surgeon confirmation that the entire tumor was above the peritoneal reflection is only required in cases where it is important to establish if the tumor is a rectal or colon primary
Colon cancer other than adenocarcinoma (e.g., sarcoma, lymphoma, carcinoid).
Prior history of invasive adenocarcinoma of colon or rectum.
colon cancer
Patients must have histologically or cytologically documented adenocarcinoma of the colon or rectum that is either metastatic, or locally advanced and unresectable; NOTE: in the event that both cecal and appendiceal primaries are considered, patient is eligible if it is concluded by the treating oncologist to most likely be cecal based on pathological, surgical, and clinical interpretation
Family history of inherited colon cancer syndromes
Patients must have histologically documented advanced or metastatic adenocarcinoma of the colon or rectum
Current or recent (=<  days prior to randomization) endoluminal stent in the stomach, bowel, colon or rectum
Histological or cytological documentation of adenocarcinoma of the colon or rectum
Histological or cytological documentation of adenocarcinoma of the colon or rectum;
Histologically proven colon carcinoma with serosal invasion or peritoneal disease or a history of tumor rupture, and/or ascites
Have pathologically confirmed colon or rectal adenocarcinoma
Diagnosis of histologically or cytologically confirmed metastatic adenocarcinoma of the colon or rectum.
Colon wall involvement
Participants must have histologically confirmed adenocarcinoma of the colon or rectum that is metastatic or locally advanced (unresectable); patients with resected primary tumors who have documented metastases are eligible; documentation of residual disease by computed tomography (CT) scan or surgeons notes is required for all patients, and histologic confirmation of metastases is strongly encouraged
Diagnosis of phenotypic classical FAP with disease involvement of the duodenum and/or colon/rectum/pouch.
Patients with an intact colon/rectum, except for clinical polyposis, and prophylactic surgery is being considered as a stratification site.
Colon/rectum/pouch with high grade dysplasia or cancer on biopsy or a large polyp (> cm) not amenable to complete removal.
Histological or cytological documentation of adenocarcinoma of the colon or rectum
Has previously undergone a left sided colon resection.
Histological or pathologically confirmed stage IV adenocarcinoma of the colon.
Histologically confirmed colon or rectal cancer with metastatic disease
Histologically or cytologically confirmed adenocarcinoma of the colon or rectum that is metastatic.
Have a history of a primary adenocarcinoma of the colon and / or rectum
Histologically or cytologically confirmed metastatic adenocarcinoma of the colon or rectum
Patients with inflammatory bowel disease or other autoimmune conditions which might affect the radiated colon or rectum
Phase Ib: Histologically or cytologically confirmed adenocarcinoma of the pancreas, colon or rectum which disease is advanced (defined as not surgically curable) or metastatic in whom combination treatment using fluorouracil, oxaliplatin and irinotecan is a rational option
Eligible patients must have been diagnosed with colon or rectal adenocarcinoma
Diagnosis of stage I-III cancers of the rectosigmoid colon or rectum
colon cancer: - prior treatments
Have been diagnosed with stage I-III colon or rectal adenocarcinoma
Carry a diagnosis of metastatic colon, rectum, or small bowel adenocarcinoma
Patient with prior history of colon cancer
Personal or family history (st degree relative) of colon cancer
Participants must have endoscopically accessible distal colon and/or rectal mucosa (i.e. participants must have at least part of the descending/sigmoid colon and/or rectum intact).
Individuals who are status post total proctocolectomy (i.e. removal of all colon and rectum).
Cytologically or histologically confirmed of primary colon or rectal adenocarcinoma with resectable cancer, who have not received any treatments for cancer
Known diagnosis of stage III colon or rectal cancer will be excluded from the study
Individuals with a history of colon resection or colectomy due to any reason
Participants must have endoscopically accessible distal colon and/or rectal mucosa (i.e. participants must have at least part of the descending/sigmoid colon and/or rectum intact)
Individuals who are status post total proctocolectomy (i.e. removal of all colon and rectum)
Have histologically confirmed solid malignancy including but not limited to: pancreas, lung, stomach, colon, rectum, bladder, breast, ovary, renal or lymphoma (hematologic), with locally advanced or metastatic disease
Pathology proven diagnosis of colon or colorectal carcinoma.
Participants must have histologically confirmed adenocarcinoma of the colon that is localized, with no evidence of distant metastasis (stage I, II, or III), and for which surgical resection of the primary tumor is being planned; OR participants must have histologically or cytologically confirmed adenocarcinoma of the colon with resectable liver metastases for which liver resection is being planned; OR participants may have a colon biopsy that is suspicious for adenocarcinoma if clinical and/or endoscopic findings strongly support the presence of malignancy, and if surgical resection is being planned; NOTE: in the unlikely event that the final pathology of the surgical resection specimen is consistent with high-grade adenoma or dysplasia, the patient will not be considered ineligible and collected research samples will still be utilized
No history of colon cancer or colon resection
History of colon cancer or colon resection
adenocarcinoma of the colon or rectum