Tumour located above the clavicle and below the jaw or occiput (neck primary) or above the jaw/occiput (head primary)
History of osteonecrosis of the jaw
Has history of osteonecrosis of the jaw
No known prior history or current evidence of osteonecrosis/osteomyelitis of the jaw
No known/planned active dental or jaw condition which requires oral surgery, including tooth extraction
Patients have prior history or current evidence of osteonecrosis or osteomyelitis of the jaw, evidence of untreated local gum or oral infection, or non-healed dental or oral surgery
Patients with active dental or jaw conditions which require oral surgery/dental procedures, including tooth extraction for the course of the study
Serious or nonhealing wound, ulcer, bone fracture, or osteonecrosis of the jaw
Prior history or current evidence of osteonecrosis/osteomyelitis of the jaw
Active dental or jaw condition that requires oral surgery, including tooth extraction
Known presence of osteonecrosis of jaw.
Pre-existing conditions\r\n* Disorders associated with abnormal bone metabolism\r\n* Hypocalcemia that is not corrected with oral calcium supplementation\r\n* Vitamin D <  mg/mL\r\n* Pagets disease\r\n* Prior history or current evidence of osteonecrosis of the jaw\r\n* Any dental or oral condition likely to result in disruption of mucosal integrity during denosumab therapy including: active dental or jaw condition requiring oral surgery or tooth extraction; non-healed dental or oral surgery or planned invasive dental procedures during the anticipated course of study therapy\r\n* Unstable systemic disease, excluding osteosarcoma, such as unstable proximal renal tubule dysfunction (Fanconi syndrome) or congestive heart failure
Patients have prior history or current evidence of osteonecrosis/osteomyelitis of the jaw
Patients have active dental or jaw condition which requires oral surgery, including tooth extraction
Prior history or current evidence of osteomyelitis/osteonecrosis of the jaw
Active dental or jaw condition which requires oral surgery
Subjects with osteonecrosis of the jaw
Significant dental/oral disease, including prior history or current evidence of osteonecrosis/ osteomyelitis of the jaw, or with the following:
Active dental or jaw condition which requires oral surgery
Current active dental problems including infection of the teeth or jawbone (maxilla or mandibular); dental or fixture trauma, or a current or prior diagnosis of osteonecrosis of the jaw (ONJ), of exposed bone in the mouth, or of slow healing after dental procedures
Recent (within  weeks) or planned dental or jaw surgery (e.g. extraction, implants)
Prior history or current evidence of osteonecrosis/osteomyelitis of the jaw
Active dental or jaw condition which requires oral surgery
Prior history or current evidence of osteonecrosis/osteomyelitis of the jaw
Active dental or jaw condition which requires oral surgery, including tooth extraction
Prior history or current evidence of osteonecrosis or osteomyelitis of the jaw, evidence of untreated local gum or oral infection, or non-healed dental or oral surgery
Active dental or jaw conditions which require oral surgery/dental procedures, including tooth extraction within  months of the study
Other risk factors for the development of osteonecrosis of the jaw (ONJ) including poor oral hygiene, use of a dental appliance, immunosuppressive therapy, treatment with angiogenesis inhibitors, systemic corticosteroids, diabetes, or gingival infections