Prior irinotecan hypersensitivity or toxicity that would suggest an inability to tolerate irinotecan  mg/m every  weeks
Inability to complete baseline QOL forms
Inability to tolerate CPI therapy {if already starte
Rapidly progressive disease which, in the opinion of the investigator, may predispose to inability to tolerate treatment or trial procedures
Inability to tolerate premedication with dexamethasone
Inability to tolerate prolonged trendelenburg position as deemed by anesthesiology
Inability to perform PFTs
Inability to tolerate intensive chemotherapy (e.g., patients with AML with %-% blasts and TRM ?).
Inability to tolerate prophylactic anti-thrombotic therapy
Inability to tolerate at least one modality of diagnostic anatomic imaging, such as CT or MRI
Perceived inability to tolerate diagnostic or therapeutic procedures
Inability to tolerate cyclophosphamide or undergo total body irradiation at the doses specified in the treatment plan
Inability to tolerate thromboprophylaxis (Cohorts B, C, E, F)
Inability to tolerate anesthesia
Inability to take or tolerate enteral medications
Inability to deliver target dose with CyberKnife due to inability to image fiducials
Inability to tolerate contrast dye for baseline CT imaging
Inability to tolerate PET and/or MRI
Inability to tolerate periodic audiologic testing or to understand a language with established scoring for word recognition testing
Significant cardiac disease resulting in inability to tolerate IV fluid hydration for cisplatin
Inability to tolerate thromboprophylaxis
Inability to tolerate transrectal ultrasound (TRUS).
Have a perceived inability to tolerate diagnostic or therapeutic procedures, particularly treatment in radiation isolation
Rapidly progressive disease which, in the opinion of the Investigator, may predispose to inability to tolerate treatment or trial procedures
Inability to tolerate thromboprophylaxis
Participants' inability to adhere to or tolerate protocol or study procedures.
Inability to tolerate PO dosing
Inability to tolerate cyclophosphamide or undergo total body irradiation at the doses specified in the treatment plan
Perceived inability to tolerate diagnostic or therapeutic procedures
inability to visualize the prostatic tissue adequately on transrectal ultrasound imaging;
Perceived inability to tolerate diagnostic or therapeutic procedures, particularly treatment in radiation isolation
Patient must be able to tolerate the procedures required in this study including periodic blood sampling, study related assessments, and management at the treating institution for the duration of the study. Inability to comply with protocol or study procedures (for example, an inability to swallow tablets) will be an exclusion criterion.
Inability to receive TBI.
Patient has inability to tolerate D CT scan (for example; contrast intravenous [IV] allergy, claustrophobia, renal disease)
Inability to complete study forms
Inability to cooperate with NIPPV
Inability to tolerate imaging procedures in the opinion of the investigator or treating physician
Inability to commit to local follow up for device management
Inability to tolerate sedated upper endoscopy due to cardiopulmonary instability or other
Have a known history of inability to absorb an oral agent
Have a known history of inability to absorb an oral agent
Inability to cooperate with the scans
Inability to tolerate imaging procedures in the opinion of an investigator or treating physician
Inability to tolerate imaging procedures in the opinion of the investigator or treating physician
Inability to tolerate imaging procedures, in the opinion of an investigator or treating physician
Inability to receive furosemide (Lasix) in the opinion of the treating investigator
Inability to adequately oxygenate the patient during the procedure
Inability to tolerate imaging procedures, in the opinion of an investigator or treating physician
Inability to tolerate additional imaging time in the opinion of the investigator or treating physician
Inability to tolerate  minutes of PET imaging
Inability to tolerate imaging procedures in the opinion of the investigator or treating physician
Inability to tolerate imaging procedures in the opinion of an investigator or treating physician
Refusal or inability to tolerate the scanning procedure (e.g., due to claustrophobia)
Inability to tolerate imaging procedures in the opinion of an investigator or treating\r\nphysician
Claustrophobia or inability to tolerate MRI examination (lay still for approximately  hour and hold breath intermittently)
Inability to tolerate imaging procedures (e.g. claustrophobia, severe pain)
Refusal or inability to tolerate the scanning procedure (e.g., due to claustrophobia)
Inability to understand and/or carry out instructions
Inability to cannulate the common bile duct
Refusal or inability to tolerate the scanning procedure (e.g., due to claustrophobia)
Inability to tolerate imaging procedure (i.e., remain relatively still for multiple short durations of - minutes) over a total time of  minutes
Contraindication for or inability to tolerate MRI examination
Inability to tolerate F-fluciclovine PET/CT
Inability to tolerate MRI including conditions such as claustrophobia or inability to lay flat for >  minutes
Inability to tolerate scanning (e.g. - claustrophobia, severe pain)
BIODISTRIBUTION COHORT: Inability to tolerate imaging procedures in the opinion of an investigator or treating physician
DYNAMIC COHORT: Inability to tolerate imaging procedures in the opinion of an investigator or treating physician