Any factors that increase the risk of corrected QT interval (QTc) prolongation or risk of arrhythmic events such as heart failure, hypokalemia, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under years of age in first degree relatives, or any concomitant medication known to the prolong the QT interval that a patient is unable to stop Patients with QTc interval > msecs or other factors that increase the risk of QT prolongation or arrhythmic events (e.g., heart failure, hypokalemia, family history of long QT interval syndrome) including heart failure that meets New York Heart Association (NYHA) class III and IV definitions are excluded Any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, hypokalemia, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under years of age in first degree relatives or any concomitant medication known to prolong the QT interval. Any factors that increase the risk of QTc prolongation or risk of rrhythmic events such as heart failure, hypokalemia, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under years-of-age, or any concomitant medication known to prolong the QT interval No congenital long QT syndrome or known st degree relative with unexplained sudden death under years of age Corrected QT (QTc) interval (i.e., Fridericas correction [QTcF]) >= ms or other factors that increase the risk of QT prolongation or arrhythmic events (e.g., heart failure, hypokalemia, family history of long QT interval syndrome) at screening Any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, hypokalaemia, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under years-of-age, or any concomitant medication known to prolong the QT interval Patients with other factors that increase the risk of QT prolongation or arrhythmic events (e.g., heart failure, hypokalemia, family history of long QT interval syndrome) that meets New York Heart Association (NYHA) class II or above Has any factors that increase the risk of QTc prolongation or risk of arrhythmic events, such as congenital long QT. syndrome, family history of long QT syndrome or unexplained sudden death under years of age in first degree relatives. Any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, hypokalaemia, congenital long QT syndrome, immediate family history of long QT syndrome or unexplained sudden death under years of age Any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, hypokalaemia, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under years-of-age, or any concomitant medication known to prolong the QT interval Mean corrected QT interval (QTc) > msec or any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as hypokalaemia, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under years of age in a next-of-kin relative. Any factors that increase the risk of QTc prolongation or risk of arrhythmic events, or unexplained sudden death under years of age in first-degree relatives or any concomitant medication known to prolong the QT interval. Any factor increasing the risk of QTc prolongation or risk of arrhythmic events such as heart failure, hypokalemia, congenital long QT syndrome, family history of long QT syndrome, or unexplained sudden death under years of age in first-degree relatives, or any concomitant medication known to prolong the QT interval. Patients with QTc interval ? msec or with other factors that increase the risk of QT prolongation or arrhythmic events (e.g., heart failure, hypokalemia, family history of long QT interval syndrome) Clinically significant ECG abnormalities or any factors that increase the risk of corrected QT interval prolongation or risk of arrhythmic events Concomitant medications known to prolong QT interval, or with factors that increase the risk of QTc prolongation or risk of arrhythmic events (such as heart failure, hypokalemia, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under years-of-age) Any patient with any factors that increase the risk of QTc prolongation or risk of arrhythmic events or unexplained sudden death under years of age in first-degree relatives or any concomitant medication known to prolong the QT interval. Any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, hypokalaemia, congenital or familial long QT syndrome or family history of unexplained sudden death under years of age or any concomitant medications known to prolong QT interval. Any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, hypokalaemia, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under years of age or any concomitant medication known to prolong the QT interval. Subjects with heart-rate corrected QT (QTc) interval ? msec or other factors that increase the risk of QT prolongation or arrhythmic events (e.g., heart failure, hypokalemia, family history of long QT interval syndrome) at screening. Patients with a corrected QT interval (QTc) at baseline of > milliseconds or other factors that increase the risk of QT prolongation or arrhythmic events (i.e., heart failure, hypokalemia with potassium < . despite supplementation, family history of long QT syndrome) should be excluded Congenital long QT syndrome, or st degree relative with unexplained sudden death under years of age Congenital long QT syndrome, or st degree relative with unexplained sudden death under years of age; Congenital long QT syndrome or st degree relative with unexplained sudden death under years of age Has any factors that increase the risk of corrected QT (QTc) interval prolongation or risk of arrhythmic events, such as congenital long QT syndrome, family history of long QT syndrome, or unexplained sudden death under years of age in first-degree relatives. Concomitant medications known to prolong QT interval, or with factors that increase the risk of QTc prolongation or risk of arrhythmic events (such as heart failure, hypokalemia, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under years-of-age)