Child Pugh B or C stage liver disease Child Pugh B or C disease Child-Pugh scores - If patient has underlying cirrhosis, only Child-Pugh classification group A patients should be included in this study; clinical assessment of ascites and encephalopathy is required; Child-Pugh classification must be determined for all study participants at the time of eligibility analysis; as albumin and prothrombin time (PT)/international normalized ratio (INR) are required for Child-Pugh classification; these labs should be drawn with other labs required for eligibility analysis Patients with Child Pugh B or C liver failure will be excluded Child-Pugh A or B Must have Child-Pugh A or B liver disease Child-Pugh C liver function Patients with Child-Pugh A and Child-Pugh B (if due to low albumin but not elevated international normalized ratio [INR] or bilirubin) cirrhosis are allowed; Child-Pugh Turcot (CPT) Classification System score will be based upon INR, total bilirubin and serum albumin, as well as the presence/absence of ascites and hepatic encephalopathy Child-Pugh B (except Child-Pugh B due to low albumin) or Child-Pugh C cirrhosis Child-Pugh status C Child-Turcotte-Pugh Classification A or B Must have Child-Turcotte-Pugh (CTP) A or B Patients with Child-Pugh A-C liver disease Patients with liver disease Child Pugh classification B and C. Child Pugh B and C Cirrhosis grade of Child-Pugh class A; Child-Pugh status should be calculated based on clinical findings and laboratory results during the screening period Child-Pugh Stage: A or B for Parts A & B, A for Part C, and D Child Pugh A If patient has underlying cirrhosis, only Child-Pugh classification Group A patients may be included in the resectable cohort of this study; for patients with unresectable disease, Child-Pugh classification Groups A and B are allowed; clinical assessment of ascites and encephalopathy is required; Child-Pugh classification must be determined for all study participants at the time of eligibility analysis; note albumin and prothrombin time (PT)/international normalized ratio (INR) are required for Child-Pugh classification; these laboratories (labs) should be drawn with the other labs required for eligibility analysis Cirrhotic status of Child-Pugh grade A. Child-Pugh status should be determined based on clinical findings and laboratory data during the screening period (Appendix B). Subjects on anti-coagulants are to receive point for their INR status, as they are presumed to have a <. baseline PT/INR. Child-Pugh Classification A (see Appendix D) Child-Pugh B-C cirrhotic status based on clinical findings and laboratory results Patients with Child Pugh liver function worse than B Child-Pugh category A Child Pugh A or B Child-Pugh A/B