Patients with untreated or active hepatitis B or C infection Are untreated. Patients must have previously untreated disease (except for one week or less of corticosteroids) Untreated active HBV Patients who are on active surveillance for untreated localized disease may not participate in this study Symptomatic untreated strictures Untreated cutaneous T-Cell non-Hodgkin lymphoma (CTCL) (with the exception of untreated tumor stage Mycosis fungoides) Previously untreated Presence of active untreated infection Previously untreated patients who decline standard therapy for their cancer are allowed to enroll Known untreated or uncontrolled acute infection, including urinary tract infection, within days of study entry Untreated active infection No known prior history or current evidence of untreated local gum or oral infection Untreated active infection Uncontrolled active, untreated, or progressive infection Untreated active major depression Uncontrolled active, untreated, or progressive infection Untreated active infection Untreated active infection Symptomatic cognitive or emotive disorder such as untreated schizophrenia, severe untreated depression, anxiety; this is determined by clinical assessment Presence of any untreated systemic infection Patients with untreated or uncontrolled neuropsychiatric illness Evidence of untreated infection Previously untreated patients with locoregional-only disease are not eligible Patient with confirmed delq mutation may be included if untreated Presence of active untreated infection Patient has untreated severe hypothyroidism Untreated, uncontrolled Sleep apnea Other untreated coexisting HIV related malignancies. Patients must be untreated with radiation above the clavicles Active untreated infection Patients with known untreated hepatitis C Untreated psychiatric conditions preventing informed consent Untreated systemic infection Untreated or uncontrolled nd malignancy Hepatitis B or C infection (HBV), or untreated systemic infection Untreated first hematologic relapse is defined as: Known untreated or unstable CNS metastatic disease. For participants enrolled in the expansion phase: lymphoma classified as either previously untreated Grade , , or a FL that requires treatment or previously untreated advanced DLBCL Untreated hepatitis B infection Any serious ongoing condition, such as an untreated infection or organ dysfunction The presence of co-existing medical conditions that would limit compliance with study medications, including, but not limited to active infection, active or untreated cardiac or pulmonary disease, or malignancy Previously untreated participants are eligible if their tumor(s) are measurable Patients must be previously untreated UNTREATED PRIMARY: Untreated N mediastinal nodal disease Active untreated infection Untreated urinary-tract infection An untreated tumor growth rate of < .% during the Screening period may exclude some patients. Active untreated infection Has untreated hypo- or hyperthyroidism; Grade >= uncontrolled or untreated hypercholesterolemia or hypertriglyceridemia Untreated bladder infection Untreated active, or inappropriately/inadequately treated breast malignancy, without surgical treatment Male patients with a history of untreated hypogonadism Patients with untreated clinically relevant hypothyroidism Severe or untreated psychiatric disease Have a diagnosis of untreated hypo- or hyper- thyroidism Patients with any of the following conditions: untreated gastrointestinal reflux disease; untreated diabetes mellitus; active thrush; active oral infection; active mucositis Patients with any of the following conditions: untreated gastrointestinal reflux disease; untreated diabetes mellitus; active thrush; active oral infection; active mucositis Untreated active infection Untreated; OR or more decayed, untreated dental sites (cavities) Previously untreated sarcomas Previously untreated subjects must have a lesion on an imaging study Untreated/unstabilized pathologic long bone fractures