Patients with right bundle branch block plus left anterior hemiblock, bifascicular block are excluded
Right bundle branch block + left anterior hemiblock (bifascicular block)
Complete left bundle branch or bifascicular block.
No presence of left bundle branch blocks (LBBB)
Significant uncontrolled cardiac arrhythmias, including ventricular arrhythmias, congenital long QT syndrome, symptomatic atrial fibrillation, symptomatic bradycardia, right bundle branch block plus left anterior hemiblock or bifasicular block
Right bundle branch block and left anterior hemiblock (bifascicular block)
Baseline Fridericia corrected QT (QTcF) >  ms; NOTE: this criterion does not apply to patients with a left bundle branch block
Any of the following concurrent severe and/or uncontrolled medical conditions which could compromise participation in the study:\r\n* ST depression or elevation of >= . mm in  or more leads\r\n* Congenital long QT syndrome\r\n* History or presence of ventricular arrhythmias or atrial fibrillation\r\n* Clinically significant resting bradycardia (<  beats per minutes)\r\n* Complete left bundle branch block\r\n* Right bundle branch block + left anterior hemiblock (bifascicular block)
Baseline QT interval corrected with Fridericia's method (QTcF) > ms NOTE: this criterion does not apply to subjects with a right or left bundle branch block (BBB)
Known congestive heart failure and/ or a known decreased cardiac ejection fraction of < %. A baseline QT interval as corrected by Fridericia's formula (QTcF) >  msec, a complete left bundle branch block (defined as a QRS interval ?  msec in left bundle branch block form) or an incomplete left bundle branch block.
Any electrocardiograph (ECG) changes that interfere with QT interval interpretation (e.g., left bundle branch block, frequent premature ventricular contractions)
DOSE EXPANSION COHORT: History or presence of an abnormal ECG which, in the investigator's opinion, is clinically meaningful; screening QTcF interval > ms is excluded; subjects with left bundle branch block are excluded
Complete left bundle branch block
Right bundle branch block + left anterior hemiblock (bi-fascicular block)
History or presence of complete left bundle branch block, heart block, cardiac pacemaker or significant arrhythmia.
Complete left bundle branch block (LBBB)
Clinically significant cardiac arrhythmias, complete left bundle branch block, high-grade AV block
Complete left bundle branch, or bifasicular block.
Abnormal ECGs that are clinically significant such as QT prolongation (QTc >  msec), clinically significant cardiac enlargement or hypertrophy, new bundle branch block or existing left bundle branch block, or signs of new, active ischemia.
A baseline QT interval as corrected by Fridericia's formula (QTcF) >  msec, a complete left bundle branch block (defined as a QRS interval ?  msec in left bundle branch block form) or an incomplete left bundle branch block.
Baseline QT interval corrected with Fridericia's method (QTcF) >  ms (average of triplicate readings) Note: This criterion does not apply to subjects with a right or left bundle branch block (BBB)
Complete left bundle branch block
Right bundle branch block + left anterior hemiblock (bifascicular block)
Right bundle branch block + left anterior hemiblock (bifascicular block)
Right or left bundle branch block
Complete left bundle branch or bifascicular block
Complete left bundle branch, or bifasicular, block.
Right bundle branch block + left anterior hemiblock (bifascicular block)
Right bundle branch block + left anterior hemiblock (bifascicular block).
A baseline QT interval as corrected by Fridericia's formula (QTcF) >  msec, a complete left bundle branch block (defined as a QRS interval ?  msec in left bundle branch block form) or an incomplete left bundle branch block.
Bundle branch block or QRS ?  msec
Complete left bundle branch block
Right bundle branch block and left anterior hemi block (bifascicular block)
Presence of left bundle branch block (LBBB)
Complete left bundle branch block
Right bundle branch block and left anterior hemiblock (bifascicular block)
Complete left bundle branch block;
Complete left bundle branch block;
Baseline Fridericia corrected QT (QTcF) >  ms; NOTE: this criterion does not apply to patients with a left bundle branch block
Right bundle branch block + left anterior hemiblock (bifascicular block)
Presence of left bundle branch block (LBBB);
Presence of left bundle branch block (LBBB)
Patients with left bundle branch block (LBBB) and/or artificial pacemaker
Impaired cardiac function including any one of the following: complete left bundle branch block or use of a permanent cardiac pacemaker, congenital long QT syndrome, presence of ventricular tachyarrhythmias, clinically significant resting bradycardia (<  beats per minute), QT interval corrected by Fridericia's formula (QTcF) >  msec on screening electrocardiogram (ECG), or right bundle branch block + left anterior hemiblock (bifascicular block)
Complete left bundle branch block
Right bundle branch block plus left anterior or posterior hemiblock