Clinically significant ascites, defined as ascites that is symptomatic or has resulted in a paracentesis in the past months Uncontrolled ascites requiring weekly large-volume paracentesis for consecutive weeks prior to initiation of study treatment Patients who had therapeutic paracentesis of ascites (> L) within the months prior to starting study treatment or who, in the opinion of the investigator, will likely need therapeutic paracentesis of ascites (> L) within months of starting study treatment. Fluctuating ascites Ascites that your doctor will manage by increasing your medications or by performing non-invasive methods (eg, paracentesis) to control, within months prior to the first scheduled dose. Clinical evidence of ascites (trace ascites on imaging acceptable) Ascites refractory to medical therapy (mild to moderate ascites is allowed) No clinical evident ascites that required therapeutic paracentesis Malignant ascites that is clinically detectable by physical examination or is symptomatic; evidence of radiographic ascites that is not clinically significant will not be an exclusion criterion COHORT B, GROUP : HEPATOCELLULAR CARCINOMA: Ascites that is not medically controlled or that required a therapeutic paracentesis within last months Clinically apparent ascites on physical examination, ascites present on imaging studies is allowed Has clinically relevant ascites at baseline (defined as requiring paracentesis) or with moderate radiographic ascites; a minimal amount of radiographic ascites is allowed Participants with uncontrolled gross ascites or encephalopathy; assessment of ascites will be determined by the treating physician Patients with any clinically apparent ascites or who have undergone a paracentesis within days of enrollment If present, clinically significant or symptomatic amounts of ascites should be drained prior to Day . Clinically significant ascites defined as requiring ? paracentesis every - weeks Clinical ascites Patients with malignant small bowel obstruction within the last months, on parenteral nutrition, clinically significant ascites (palpable on physical exam and/or causing symptoms) or ascites requiring fluid removal more than twice in the last weeks Subjects with clinically apparent ascites or encephalopathy, or untreated varices are not eligible for enrollment Ascites requiring active medical management including paracentesis Moderate to large volume ascites. Significant ascites that require therapeutic paracentesis At risk for hepatic or renal failure\r\n* Serum creatinine > . mg/dl\r\n* Serum bilirubin > . mg/ml\r\n* Albumin < . g/dL\r\n* Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > times upper normal limit\r\n* Any history of hepatic encephalopathy\r\n* Cirrhosis or portal hypertension\r\n* Clinically evident ascites (trace ascites on imaging is acceptable) Presence of ascites (as determined by clinician) Ascites refractory to medical therapy Ascites refractory to medical therapy Any evidence of ascites (beyond trace) No clinical evidence of hepatic failure (e.g. coagulopathy, ascites) Patients with current cirrhotic status of Child-Pugh class A only (- points with total bilirubin < mg/dL for dose-escalation) with no encephalopathy and no clinical ascites (ascites controlled by diuretics is also excluded in this study). Evidence of significant ascites as determined by the investigator Hepatic blood flow abnormalities and/or large-volume ascites Presence of ascites that is not medically controlled or that required a therapeutic paracentesis within the last months prior to initiation of study therapy Ascites requiring active medical management, including paracentesis Ascites requiring active medical management including paracentesis. Patients with radiographic ascites that is apparent on physical exam or requiring medical intervention (medication or procedures) in the months prior to enrollment Patients must be willing and able to undergo ascites fluid collection pre- and post-study treatment if adequate ascites is present; patients without adequate ascites may also participate in the trial Has clinically apparent ascites on physical examination. Note: ascites detectable on imaging studies only ARE allowed. Clinically evident ascites (trace ascites on imaging is acceptable) Any prior (within year) or current clinically significant ascites as measured by physical examination and that requires paracentesis for control; Clinically significant ascites Have greater than grade ascites at time of enrollment. Clinical evidence of ascites by physical exam Patients with ascites requiring paracentesis within weeks prior to study entry (signature of informed consent) and during the screening period. Have presence of clinically relevant ascites. Any prior or current clinically significant ascites Significant or symptomatic amount of ascites should be drained prior to first dose of BBI. Ascites requiring active medical management including paracentesis. Clinically evident ascites (trace ascites on imaging is acceptable) Has clinically apparent ascites on physical examination No clinical ascites (mild ascites on scans permissible) Ascites requiring intervention Subject has uncontrolled symptomatic ascites. Uncontrolled or clinically relevant ascites Histologically confirmed metastatic ovarian or GI malignancy with malignant ascites amenable for paracentesis; adjudication of malignant ascites can be made on clinical grounds e.g. in the absence of cirrhosis or other non-malignant causes of ascites Ascites requiring paracentesis within the days prior to randomization Presence of clinically significant ascites No moderate-to-severe ascites (subjects with ascites restricted to the perihepatic space or pelvic cavity) Clinical ascites Clinically evident ascites (trace ascites on imaging is acceptable) Uncontrolled ascites defined as not easily controlled by stable doses of diuretics Uncontrolled ascites (defined as not easily controlled with diuretic or paracentesis treatment). Ascites detected by CT, ultrasound (US) or MRI; (trace ascites will not be an exclusion) Patients cannot have active ascites Subjects with refractory ascites, defined as ascites needing drainage catheter or therapeutic paracentesis more often than every weeks Recurrent symptomatic malignant ascites having required at least paracenteses within a -day interval prior to baseline paracentesis Compensated cirrhosis defined as a Child-Pugh score of or at Screening A minimal rim of ascites if detected at imaging is acceptable. Exclude ascites that requires the need to apply diuretic treatment to control ascites Patients with clinically evident ascites requiring medical management or paracentesis, or Childs-Pugh score B/C are not eligible Clinically significant ascites or clinical evidence or history of portosystemic hypertension or cirrhosis. No signs of decompensated liver cirrhosis or ascites requiring therapeutic paracentesis Uncontrolled ascites requiring weekly large volume paracentesis for consecutive weeks prior to enrollment Poorly controlled ascites and/or requirement for therapeutic paracentesis more frequently than once every months. Clinically significant ascites Unwilling to allow removal of tumor biological samples for analysis, i.e., biopsies of tumor lesions, and/or collection of ascites fluid from abdominal ascites (if present) Presence of ascites that requires paracentesis more frequently than once every days. Presence of ascites that preclude biopsy of liver lesions. Subjects with sensory neuropathy, ascites, or plastic biliary stent. Subjects with clinically significant ascites Clinically evident ascites History of recurrent ascites requiring paracentesis within weeks of study day . History of medically significant ascites requiring repetitive paracentesis Evidence of ascites on imaging study, or the use of diuretics for ascites Patients with clinically significant ascites requiring paracentesis on or more occasions within weeks prior to start of study treatment Ascites requiring paracentesis for symptom improvement Significant peri-hepatic ascites interfering with safe/effective PTBD. Patients presenting with ascites Presence of ascites Ascites absent Uncontrolled large ascites Clinically or radiographically detectable ascites (beyond trace/rim of ascites) or ascites requiring medication Minimal or non-symptomatic ascites Ascites or other clinical or radiographical signs of portal hypertension Uncontrolled ascites that is not stable with medical management (i.e., on diuretics and salt restriction) as defined by requiring therapeutic paracentesis more than once every weeks. Uncontrolled ascites requiring weekly large volume paracentesis for consecutive weeks prior to enrollment