Must have achieved an objective response (CR/PR) or stable disease (SD) upon completion of scheduled treatment Patient must have chemosensitive disease as defined by at least a partial response to salvage therapy at their latest assessment Patients must have received first-line/induction systemic therapy comprising of immunotherapy and/or platinum-based chemotherapy (a total of cycles or courses), and achieved stable disease or a partial response. Patients who are known to be experiencing an objective partial response to immunotherapy at the time of study enrollment Patients must have achieved a response to induction chemotherapy (either CR or PR by Cheson criteria) and be without known progression failed to achieve at least a partial response after or more cycles; failed to achieve a complete response after or more cycles; and/or progressed after an initial response Relapsed or refractory disease, defined by failure to achieve a partial response within months of initiation of therapy, or a % increase of baseline disease measurements after achieving a clinical response Participants who achieve either a partial response or stable disease >= months must agree to undergo a tumor biopsy, if safe and feasible, at the time of progressive disease while on study drug everolimus Is willing to provide additional archived samples for comprehensive genomic and/or proteomic analyses if the subject has a partial response/complete response to DS-b treatment. Achieved at least a partial response (PR) to therapy Patients must be considered bevacizumab-resistant, i.e.; have a treatment-free interval following a response to bevacizumab (complete response [CR], partial response [PR], or stable disease [SD]) of less than months, or have progressed during treatment with a bevacizumab-containing therapy Progression (according to IWG criteria) at any time after initiation of AZA or DAC treatment or Failure to achieve complete or partial response or hematological improvement (HI) (according to IWG) after at least six -week cycles of AZA or either four -week or four -week cycles of DAC administered or Relapse after initial complete or partial response or HI (according to IWG criteria) Treatment for ? months with inadequate efficacy response defined as <% spleen volume reduction by MRI or <% decrease from baseline in spleen length by physical examination or regrowth to these parameters following an initial response; and/or Received a minimum of cycles of standard of care platinum-based chemotherapy in the S setting and had a response of progressive metabolic disease (PMD), no metabolic response (NMR), partial metabolic response (PMR) as centrally assessed by PET-/ CT scan or received at least cycle of S chemotherapy and had evidence of PMD as centrally assessed. A pre-salvage scan is required to be submitted to the central reader if a subject had only cycle of pre-salvage chemotherapy. Patients must have received pre-study nivolumab for up to months and have consecutive tumor assessments confirming Complete response (CR), Partial response (PR), or Stable disease (SD) History of at least one anti-CD antibody containing regimen that resulted in initial measurable response (partial or complete remission), followed by relapse/recurrence. Completed to months ( weeks) of initial therapy, during which the participant was treated to best response, defined as the best response maintained for cycles after the M-protein nadir is reached. Relapsed or refractory disease, defined by failure to achieve a partial response within months of initiation of first line therapy, or a % worsening of baseline disease measurements (i.e., lymph node size, splenomegaly, lymphocytosis, anemia, thrombocytopenia, hepatomegaly) after achieving a clinical response Patients with documented history of no response to cladribine, and without % improvement in platelets, hemoglobin or granulocytes; this exclusion does not apply to HCLv; these patients are eligible regardless of prior response to cladribine (CDA) Lack of a complete response after receiving ibrutinib for > year OR presence of known ibrutinib resistance mutation Patients must have received treatment on PBTC- or PBTC-B for a minimum of courses with at least stable disease, or had a sustained response (partial response [PR]/ complete response [CR]) but remained on treatment < courses Absence of a documented partial response (PR) or complete response (CR) according to RECIST . or CA response by Gynecologic Cancer Intergroup (GCIG) criteria to neoadjuvant chemotherapy Principal Investigator adjudicated efficacy response defined as either transfusion independence\, \stable disease\, \minor HI-E response\ or \major HI-E response\ and in the opinion of the Principal Investigator the patient may benefit from continued treatment with OPN- monotherapy or combination treatment with azacitidine. Histologically or cytologically confirmed pancreatic adenocarcinoma with metastasis, who had obtained a best response of at least stable disease (SD) or a partial response (PR) for a period of months with no further shrinkage of ? % on scan on their first line of chemotherapy for their advanced metastatic disease. Note: Patients that have had prior chemotherapy as adjuvant or neoadjuvant therapy are permitted. Previous tumor response to PD- or PD-L inhibiting therapy\r\n* Note: Tumor response is defined as complete response (CR), partial response (PR), or stable disease (SD) that is durable for at least weeks REP ELIGIBILITY: Has not had a partial or complete response to nivolumab treatment Patients with complete response (CR)/very good partial response (VGPR) disease Have relapsed or refractory disease after at least prior regimen, including: \r\n* Recurrence of disease after a documented complete response (CR) \r\n* Progression of disease after a partial response (PR) to the prior regimen \r\n* Partial response (PR), stable disease (SD) or progressive disease (PD) at the completion of the prior treatment regimen; if a patient has PR to prior regimen without PD, there must be biopsy-proven residual disease that is measurable Patients with resistant disease (initial or at relapse): those who fail to achieve an objective partial response to three cycles of combination non-cross resistant chemotherapy will not be eligible for transplant in this trial Chemo-sensitive (defined by complete response [CR] or partial response [PR] to most recent chemo regimen) based on pre-transplant positron emission tomography (PET) within weeks of autologous transplant Stable disease (SD) as best response after at least cycles of first-line therapy Partial response (PR) as best response after at least cycles and biopsy-proven residual disease or disease progression ? months from initiation of therapy Patients with HCL must be intolerant of or not candidates for purine analog-based therapy, or failed to achieve response (CR or partial response [PR]) or relapsed within years of such therapy, AND meet the standard treatment initiation criteria (absolute neutrophil count [ANC] =< /uL, hemoglobin [Hgb] =< g/dL, platelet count =< ,/uL); patients with indolent lymphoma (FL, LPL, MZL) and patients with B-cell prolymphocytic leukemia must have an indication for treatment in the opinion of the investigator; patients with MCL and patients with CLL in Richters transformation should have previously received or not be candidates for high dose chemotherapy/autologous stem cell transplant Relapsed T-cell lymphoma that is chemotherapy sensitive in CR/partial response (PR) that has failed or ineligible for an autologous transplant Relapsed within year of first response Failure to achieve at a minimum partial response based on organ assessment after days compared to organ stage at the time of initiation of high-dose systemic corticosteroid +/- CNI for the treatment of Grade II-IV aGvHD,OR Achieving partial response (PR) or very good partial response (VGPR) with systemic chemotherapy Patients who achieved complete response (CR) prior to autologous HCT Loss of complete hematologic response (CHR) Patients must have achieved at least partial response (PR) prior to autologous HCT and must not have progressive disease (PD) prior to the initiation of maintenance therapy Presence of measurable or evaluable disease (unless patient has achieved a complete response (CR) following first-line antineoplastic therapy). Patients without measurable or evaluable disease (unless patients achieved a complete response (CR) following st-line antineoplastic therapy). Patients must have a history of tumor progression or persistent disease or failure to achieve complete response following standard therapy Patients with complete response (CR)/very good partial response (VGPR) disease Patients must be currently receiving ibrutinib for at least months prior to enrollment in the study and:\r\n* Not experiencing any >= grade non-hematologic ibrutinib-related toxicity\r\n* The best response to ibrutinib therapy must not have exceeded partial response or stable disease (i.e. no complete response [CR] or complete response with incomplete marrow recovery [CRi])\r\n* Note: patients carrying a deletion at chromosome p (i.e. deletion [del][p]), and/or tumor protein (TP), Bruton's tyrosine kinase (BTK), and at the phospholipase C, gamma (PLCgamma ) loci mutations, will be eligible if they are receiving frontline therapy with ibrutinib Participants who received at least only one line of previous therapy and achieved either complete response (CR) or partial response (PR) for at least weeks (from the last day of the last cycle) after their first line of therapy, but are not eligible for high dose chemotherapy with autologous stem cell transplantation (HD-ASCT) Medically unresectable (stage I-II) or locally advanced (stage III); patients with distant metastases (stage IV) must have stable disease or improved disease (partial response, or complete response) per Response Evaluation Criteria in Solid Tumors (RECIST) criteria as determined on serial imaging following a course of chemotherapy Has clinical response or stable disease for minimum of two months (three cycles of every three week chemotherapy or weeks of weekly regimen, etc.) after receiving any prior chemotherapy for metastatic/recurrent disease; a minimum of two cycles (- weeks) of chemotherapy is required to determine clinical response; per Response Evaluation Criteria in Solid Tumors (RECIST) criteria ., clinical response for measurable disease is defined as complete response (CR) or partial response (PR); for non-measurable disease only (i.e. bone metastasis, ascites, pleural effusion, and pathological lymph nodes >= to < mm short axis) is defined as persistence of one or more non-target lesion(s) and no increase in overall tumor burden Patients must meet one of the following criteria:\r\n* The presence of refractory or progressive disease (PD) prior to or following completion of standard therapy for MIBG avid tumors\r\n* For patients with neuroblastoma, the presence of mixed response (MR), or no response (NR) following the completion of A or equivalent induction therapy, or the presence of a partial response (PR) with high Curie score (> ) following induction therapy \r\n* Patients with de novo high risk neuroblastoma who have completed standard induction therapy and do not achieve a complete response (CR), very good partial response (VGPR), or PR with low Curie score post induction are eligible; for patients with neuroblastoma the revised International Neuroblastoma Response Criteria (INRC) shall be used to assess pre-treatment disease status Patient must have had a diagnosis of high risk NB at initial diagnosis or if non-high risk at time of initial diagnosis must have had evidence of metastatic progression when > months of age\r\n* Patient must have measurable or evaluable disease occurring as one of the following:\r\n** Disease progression after initiation of upfront NB therapy defined as:\r\n*** New disease site documented on MIBG scintigraphy; or computed tomography (CT)/magnetic resonance imaging (MRI); or any new bone site that is fludeoxyglucose F- (FDG)-positron emission tomography (PET) avid (in patient known to have MIBG non-avid tumor) AND has MRI findings consistent with tumor OR has a biopsy showing NB or ganglioneuroblastoma\r\n*** Greater than % increase in a least one dimension of soft tissue mass documented by CT/MRI AND a minimum absolute increase of mm in longest dimension in existing lesions\r\n*** Bone marrow biopsy meeting revised International Neuroblastoma Response Criteria (INRC) criteria for progressive disease\r\n** Refractory disease such that response to upfront therapy (defined as at least cycles of multi-agent induction chemotherapy) is less than partial response\r\n** Persistence of disease after at least a partial response to frontline therapy (i.e. patient has had at least a partial response to frontline therapy but still has residual disease by MIBG scan, CT/MRI, or bone marrow aspirate/biopsies); patients in this category are REQUIRED to have histologic confirmation of viable NB from at least one residual site; tumor seen on routine bone marrow morphology is sufficient Refractory disease (i.e. less than a partial response to frontline therapy) Persistent disease after at least a partial response to frontline therapy (i.e. patient has had at least a partial response to frontline therapy but still has residual disease by MIBG, CT/MRI, or bone marrow) Patients must have detectable BCR-ABL transcript levels meeting at least of the following criteria: Patient has never achieved a major molecular response (MMR, as defined by a BCR-ABL/ABL months from date when first response first documented or if they are good candidates for HCT. For tumors other than DSRCT, patients must have a history of tumor progression or recurrence or failure to achieve complete response with standard therapy or < % chance of long term disease-free survival Patients must have had a response to chemotherapy, which the investigator feels is likely to resulting systemic control of the cancer; in most instances, this would reflect a major response (i.e. > or = % reduction of tumor), though a lower percentage may be acceptable if the investigator feels the residual reflects another component, such as transitional cell carcinoma (TCC); Dr Arlene Siefker-Radtke will serve as the final arbiter when questions regarding response arise Advanced non-Hodgkin lymphoma (NHL): A) low-grade NHL (Working Formulation A, B, C) following progression after initial therapy if asymptomatic at diagnosis (>= CR, >= PR; response duration < year from last therapy) or if no CR was achieved (> PR); at least one prior therapy of intermediate intensity (e.g. cyclophosphamide, doxorubicin, vincristine, prednisone [CHOP]); B) mantle zone lymphoma after any progression following initial therapy (> CR, > PR); at least one prior therapy of intermediate intensity (e.g. CHOP); C) intermediate grade lymphoma (> PR); response duration < year from prior therapy; D) high-grade NHL (IWF H, I, J) after initial therapy if >= stage III at diagnosis; after any progression even if localized (stage I, II) at diagnosis with prior response duration < year; E) recent chemotherapy responsiveness after treatment with >= intermediate intensity regimens Poor Prognosis Non-Seminomas Germ Cell Tumor in >= partial response (PR)/complete response (CR) or Good or Intermediate Prognosis Seminomas and Non-Seminomas Germ Cell Tumor in >= PR or >= CR as defined by the International Germ Cell Cancer Consensus Classification; Patients with increasing tumor markers only (i.e., no imaging evidence of progressive disease) are eligible for transplant Must have a history of tumor progression or recurrence or failure to achieve complete response with standard therapy Have achieved a response (partial response (PR) or better) to at least prior therapy. >= months after completing any line of chemotherapy, or after autologous stem cell transplantation, and having attained either a very good partial response (VGPR) or a complete response (CR), and without the need for haematological maintenance therapies Inclusion Criteria for Group Confirmed free light chain complete response (CR) during the first three cycles of first-line chemotherapy where at least the first cycle has been with cyclophosphamide, bortezomib, dexamethasone (CyBorD). are in relapse following an initial response and no more than prior salvage therapy Patients who never achieved at least minor response (MR) to at least one prior line of therapy Patients must have at least ONE of the following: ) Recurrent/progressive disease at any time (biopsy not required, even if partial response to intervening therapy); ) Refractory disease (i.e., less than a partial response to frontline therapy, including a minimum of cycles of chemotherapy) (no biopsy is required for eligibility for this study); ) Persistent disease after at least a partial response to frontline therapy (i.e., patient has had at least a partial response to frontline therapy but still has residual disease by MIBG scan, CT/MRI, or bone marrow) (patients in this category are REQUIRED to have a biopsy [bone marrow biopsy included] of at least one residual site demonstrating viable neuroblastoma) For study cohort B, must have had previous treatment with cetuximab or panitumumab with disease control (defined as complete response, partial response, or stable disease) lasting for ? months in duration Previous treatment with cetuximab with evidence of clinical benefit, as defined by complete response, partial response, or prolonged stable disease with or more weeks of treatment without radiographic progression, as assessed by the treating physician and documented in the medical record; this treatment may have occurred at any point in the patients clinical course for treatment of metastatic colorectal cancer Subjects with recurrence must have a documented complete response upon completion of initial definitive therapy Participants must have received - cycles of platinum-based first-line chemotherapy and must have an ongoing response of complete response (CR), partial response (PR), or stable disease (SD) after completion of chemotherapy; acceptable combinations, as recommended per NCCN guidelines, include cisplatin or carboplatin combined with either etoposide or irinotecan\r\n* As an exception to the above criterion, participants receiving only cycles of chemotherapy due to toxicity are eligible, if they have an ongoing PR or CR after the third (rd) cycle\r\n* Participants who have received > cycles of platinum-based first-line chemotherapy are not eligible Patients must have at least ONE of the following:\r\n* Recurrent/progressive disease at any time prior to enrollment - regardless of response to frontline therapy\r\n* Refractory disease: persistent sites of disease (after less than a partial response to frontline therapy, following a minimum of cycles of induction therapy) AND patient has never had a relapse/progression\r\n* Persistent disease: persistent disease after achieving at least a partial response to frontline therapy after a minimum of cycles of induction therapy and patient has never had a relapse/progression Patients must have a complete cytogenetic response (CCyR) OR must have been on nilotinib for a minimum of six months Patients with resistant disease (initial or at relapse): those who fail to achieve an objective partial response to three cycles of combination non-cross resistant chemotherapy will be ineligible for transplant in this trial Achieved a response of stable disease, partial response, or complete response following the last cycle of frontline treatment. In addition, patients must have relapsed less than or equal to months from the completion of frontline therapy at the time of initial dosing in this clinical trial. Patients must have had a complete response to front-line platinum-taxane therapy (at least three cycles) Patients must have achieved stable disease, a partial response, or a complete response at their first disease assessment after initiating first-line platinum-based chemotherapy; patients determined to have progressed (in the opinion of the treating physician) at their first disease assessment are not eligible Patient must have clinical complete response or partial response following completion of chemotherapy course. Relapsed melanoma: Subjects must have received prior anti?PD- or anti?PD-L therapy (alone or as part of a combination) in the advanced or metastatic setting and achieved partial response ore complete response but later have confirmed progressive disease. Patients must have relapsed neuroblastoma, refractory neuroblastoma that had less than a partial response to standard treatment or persistent neuroblastoma that had at least a partial response to frontline therapy frontline therapy with > residual lesions on end-induction MIBG scan. Must have achieved at least a minimal response (MR) to at least prior anti-myeloma regimen before developing PD (relapsed) All patients must have received at least one prior therapy - cycle of cytarabine containing regimen or cycles of hypomethylating agent - before determination of refractory status (defined as response duration less than months or no response) Achieved less than a partial response (= weeks as assessed by the investigator CR, partial response (PR) or stable disease (SD) after Step Miller-Payne response in the breast of -. Patients must have a history of tumor progression or persistent disease or failure to achieve complete response following standard therapy Patients with complete response (CR)/very good partial response (VGPR) disease Patients taking ruxolitinib at the time of enrollment must be deemed to have had a suboptimal response (less than partial response per IWG criteria) to ruxolitinib single-agent therapy or deemed to have progression of disease (per IWG criteria) Histologically or cytologically confirmed extensive-stage disease small cell lung cancer (ED SCLC) with ongoing clinical benefit (stable disease [SD], partial response [PR], or complete response [CR]) following completion of cycles of first-line platinum-based therapy Patients meeting the Durie and Salmon criteria for initial diagnosis of multiple myeloma, requiring therapy and meeting one of the following:\r\n* After initial therapy in either first complete or partial remission or no objective response\r\n* After achieving initial response and later disease progression, patient will be eligible after subsequent therapy upon achievement of either complete or partial response Patients with chronic myeloid leukemia (CML) in chronic phase who have resistance and/or intolerance to frontline TKI therapy; resistance is defined as lack (lack defined as response not achieved or lost by the given dates mentioned hereafter) of CHR (complete hematologic response) within months, lack of major cytogenetic response (MCyR) within months, and lack of CCyR within months of therapy with frontline TKIs; in addition, loss of MCyR, CCyR or MMR at any time during the course of therapy is also considered resistance to therapy; intolerance is defined as persistent or severe toxicity that is unacceptable to the patient Be actively receiving duvelisib monotherapy on the previous study (within days of study entry) and demonstrating clinical benefit (complete response [CR]/ partial response [PR]/ stable disease [SD]) of continued use, or Documented response of at least partial response (PR) to line of prior therapy Must have stable disease or disease response as evidenced on CT evaluation a minimum of days and a maximum of days following the completion of chemoradiation Documented response to ASCT (PR, VGPR, CR/stringent complete response [sCR]) according to IMWG criteria. Must have received at least prior line of therapy for multiple myeloma and achieved a response (partial response or better) to at least one prior regimen Patients must have received first line chemotherapy, from - cycles, and achieved stable disease or a partial response Currently progressing, resistance to or with a suboptimal response to their most recent therapy A very good partial response (VGPR) or better after induction therapy with/without consolidative high-dose therapy/autologous stem cell transplantation (HDT/ASCT).\r\n* Very good partial response (VGPR): \r\n** Serum and urine M-component detectable by immunofixation but not on electrophoresis or\r\n** >= % or greater reduction in serum M-component plus urine M-component < mg per hours (h)\r\n* Complete response (CR):\r\n** Negative immunofixation of serum and urine and\r\n** Disappearance of any soft tissue plasmacytomas and\r\n** < % plasma cells in bone marrow\r\n* Stringent complete response (sCR)\r\n** CR as defined above plus\r\n** Normal free light chain ratio and\r\n** Absence of clonal cells in bone marrow by immunohistochemistry or immunofluorescence\r\n* MRD positive by flow cytometry receiving ibrutinib for at least months with a response less than complete response/remission (CR) and have high-risk features as defined in inclusion criterion a Patients must be, in the opinion of the investigator, in response (partial or complete radiological response), or may have no evidence of disease (if optimal cytoreductive surgery was conducted prior to chemotherapy), and no evidence of a rising CA-, following completion of this chemotherapy course Subjects must have entered the Maintenance Phase and are under ongoing maintenance treatment or subjects who stopped maintenance treatment because of a complete response (CR) or subjects with an initial partial response (PR) or CR or at least months of stable disease (SD) on tumor assessment and who subsequently have a confirmed and documented disease progression (per immune-related Response Evaluation Criteria in Solid Tumors [RECIST] criteria) Patients must have, in the opinion of the investigator, clinical complete response or partial response and have no clinical evidence of disease progression on the post treatment scan or rising CA- level, following completion of this chemotherapy course. Patients with stable disease on the post-treatment scan at completion of first line platinum-containing therapy are not eligible for the study. They must have recurrent melanoma with measurable or evaluable sites of disease, . cm or larger, in order to assess the response to treatment by the immune-related response criteria (irRC) Participants must have achieved a complete or partial response per disease-appropriate imaging technique (to be determined by the study principal investigator) within weeks of study entry following administration of chemotherapy Subject had no response (i.e., stable disease only) to first-line therapy with R-Cyclophosphamide, Hydroxydaunomycin, Vincristine (Oncovin), Prednisone (R-CHOP) or an equivalent regimen; Cohorts and : Participants must have stable disease or be responders (partial response [PR] or complete response [CR]) to neratinib in the CNS at the time of non-CNS progression CLL patients with evidence of residual disease, who have achieved partial response (PR), nodular partial response (nPR) or complete response (CR) with detectable minimal residual disease (MRD) following upfront therapy consisting of pentostatin, cyclophosphamide and rituximab\r\n* The presence of MRD will be assessed by the flow cytometry and polymerase chain reaction at the Memorial Sloan Kettering Cancer Center (MSKCC) Diagnostic Molecular Pathology Laboratory Patients with DLBCL transformed from indolent lymphoma must have had a complete or partial response to a therapy for NHL lasting at least weeks. Measurable disease is not required for this study, since the primary endpoint is complete pathologic response Best response achieved was ?Partial Response (PR) * Patients with complete response to first-line chemotherapy with no measurable target for SBRT/RT Patients achieving < partial response following preceding chemotherapy (cohort ) or < very good partial response following autologous stem cell transplantation (cohort ) Patients with complete response, partial response, or stable disease following , or cycles of first-line chemotherapy with pemetrexed AND either cisplatin or carboplatin; a maximum of cycles of chemotherapy may have been given Could have been treated neoadjuvantly but have not reached pathologic complete response. Patients who have stable (SD) or responding disease (PR or CR) documented by the appropriate radiological, clinical, or laboratory assessments within weeks before enrollment (Note: response criteria from the previous AG- protocol should be used to determine stable or responding disease). Must have achieved a minimum response of partial response (PR, nPR, CRi, CR, and MRD-negative CR) (IWCLL guidelines for the diagnosis and treatment of chronic lymphocytic leukemia [Hallek, ]) following completion of second-line induction therapy prior to randomization (documentation of response status must be available). Second-line induction therapy must be documented to have been of sufficient duration. TIER I SUBJECTS: Patients with relapsed follicular lymphoma achieving at least a PR following their most recent systemic chemotherapy and/or immunotherapy regimen; Tier I subjects must have had at least two prior chemotherapy and/or immunotherapy regimens; partial response from pre-study regimen may be either a clinically determined response by the principal investigator or physician co-investigator member of the study team, or a measured response as per the response criteria of this protocol TIER I SUBJECTS: Patients with relapsed follicular lymphoma with stable disease and no lymph node mass greater than cm (in any one dimension) following at least two systemic chemotherapy and/or immunotherapy regimens; stable disease from pre-study regimen may be either a clinically determined response by the principal investigator or physician co-investigator member of the study team, or a measured response as per the response criteria of this protocol TIER II SUBJECTS: Patients with follicular lymphoma who have achieved at least a partial response with an initial chemotherapy and/or immunotherapy regimen; response from pre-study regimen may be either a clinically determined response by the principal investigator or physician co-investigator member of the study team, or a measured response as per the response criteria of this protocol TIER II SUBJECTS: Patients with follicular lymphoma who have stable disease and no lymph node mass greater than cm (in any one dimension) following an initial chemotherapy and/or immunotherapy regimen; response from pre-study regimen may be either a clinically determined response by the principal investigator or physician co-investigator member of the study team, or a measured response as per the response criteria of this protocol Must have achieved at least a minor response to any previous regimen according to adapted European Group for Blood and Marrow Transplantation (EBMT) criteria Patients with will be eligible if they are either in partial response, or have stable disease after no more than two attempts of induction therapy Documented objective response or stable disease lasting for months or more to last prior anti-EGFR (cetuximab or panitumumab) in combination with irinotecan or FOLFIRI Patients must have chemo-sensitive disease achieving at least partial response (Cheson criteria) to last chemotherapy Chemo-refractory disease as determined by less than partial response (Cheson Criteria) to last chemotherapy Patients with advanced phase CML or acute leukemia must have failed at least one prior TKI; patients with chronic phase CML must have failed, have resistance or suboptimal response to at least two tyrosine kinase inhibitors, or have intolerance to two prior tyrosine kinase inhibitors; for patients with prior intolerance, they should have received at least TKI and experienced intolerance to one TKI and resistance/suboptimal, a. failure to tyrosine kinase inhibitors will be defined per European-Leukemia-Net (ELN) recommendations, b. resistance or suboptimal response to at least two prior Abl-kinase inhibitor, specifically: i. chronic-phase with resistance to imatinib, dasatinib, nilotinib, bosutinib or ponatinib defined as . loss of complete cytogenetic response (CCyR) at any time or failure to achieve CCyR after >= months, . loss of major cytogenetic response (MCyR) at any time or failure to achieve partial cytogenetic response (PCyR) after >= months, . failure to achieve any cytogenetic response (CyR) (ie, >= % Philadelphia chromosome [Ph]+) after >= months, . hematologic relapse or failure to achieve complete hematologic response (CHR) after >= months, ii. chronic-phase with suboptimal response to imatinib, defined as . failure to achieve PCyR after >= months, . failure to achieve CCyR after >= months, iii. chronic-phase with suboptimal response to nilotinib, bosutinib, dasatinib or ponatinib, defined as . failure to achieve PCyR after >= months, . failure to achieve CCyR after >= months of therapy Patient must have radiologic demonstration of stable disease or tumor response Patient has achieved CR or partial response (PR) per per investigator's assessment following completion of CHOP-based therapy and has had radiological assessment within days prior to randomization. They must have recurrent melanoma with measurable or evaluable sites of disease, . cm or larger, in order to assess the response to treatment by the immune-related response criteria Must be within days of completion of first-line treatment regimen; must have achieved complete response (CR/unconfirmed complete response [CRu]) to first-line treatment No response to last line of therapy i. PD as best response to most recent therapy regimen ii. SD as best response to most recent therapy with duration no longer than month from last dose of therapy OR Multiple myeloma\r\n* No prior auto hematopoietic transplantation (HCT) fitting into one of the following categories:\r\n** Early disease stage (first complete response [CR]/first partial response [PR]) with high-risk molecular features:\r\n*** By FISH or cytogenetics:\r\n**** t(;)\r\n**** t(;) \r\n**** t(;)\r\n**** - or -p\r\n**** -p or +q\r\n*** By cytogenetics:\r\n**** - or -q\r\n*** By gene expression profile (GEP):\r\n**** High risk GEP\r\n** Early disease stage (CR/PR) with high-risk clinical features:\r\n*** Plasma cell leukemia at presentation\r\n*** Poor count recovery after chemotherapy, making collections from autologous HCT unlikely to be adequate\r\n** Late disease stage (CR/second partial response [PR+]) with high- risk clinical features\r\n*** Minimal (< % reduction of serum M protein or free light chains, or if non-secretory, < % reduction in marrow plasma cell burden) response or progression after therapy with at least two novel agents, including lenalidomide and bortezomib, who demonstrates chemosensitivity to any other salvage regimen\r\n*** Poor count recovery after chemotherapy, making collections for autologous HCT unlikely to be adequate Response to previous RELHEM treatment: at least resistant disease with clinical benefit or better response Subjects with EGFR-mutated lung cancer may continue erlotinib if they have been on the drug for >= months with stable disease or a response; erlotinib may also be continued in the case of a progressing tumor after prior response (or > months stable disease) Prior to registration, patients must have achieved clinical benefit with crizotinib monotherapy and subsequently have systemically progressed; clinical benefit is defined as having stable disease on crizotinib monotherapy for at least days or achieving a confirmed partial or complete response; systemic progression is defined as progressive disease based on Response Evaluation Criteria in Solid Tumors (RECIST) version ., excluding progression based on brain/CNS metastases alone Patients must have achieved a complete response (CR) or partial response (PR), as defined by Response Evaluation Criteria in Solid Tumors (RECIST) ., following treatment for recurrent ovarian, fallopian tube, or peritoneal cancer; histological confirmation of the original primary tumor is required Patients with a complete response (CR) to their previous regimen must have a cancer antigen (CA)- within normal range; this criterion is not applicable to patients who enroll with a partial response (PR) to their previous regimen Relapsed (progressed after prior response) or refractory (failed to achieve at least a partial response) to at least one prior therapy for amyloidosis. No response or loss of response to Erythropoiesis-Stimulating Agents (ESAs) or erythropoetin (EPO) > mU/ml Patients must have at least ONE of the following: Recurrent/progressive disease at any time prior to study enrollment - regardless of response to frontline therapy. Refractory disease: persistent sites of disease after achieving a best overall response of no response to front line therapy after a minimum of cycles of induction therapy AND patient has never had recurrent/progressive disease. Persistent disease: persistent sites of disease after achieving a best overall response of partial response to frontline therapy after a minimum of cycles of induction therapy AND patient has never had recurrent/progressive disease. Patients must have documented at least partial response (PR) to at least line of prior therapy. PR documentation can be based on Investigator assessment. Relapse or disease progression following response to prior rituximab-based therapy, requiring treatment by Revised Response Criteria for Malignant Lymphoma (RRCML) guidelines. Subjects who have received prior bendamustine are eligible if they achieved a response (CR/PR) which lasted > months after the end of bendamustine containing treatment. Achieved a response to at least one prior regimen Patients must have had a significant response to standard frontline therapy judged as a complete response or a very good partial response (especially for irradiated sites where complete response [CR] is often impossible to ascertain); clear evidence for persistent or progressive cancer or the administration of a salvage regimen for persistent or progressive disease precludes enrollment on Cohort ; administration of consolidation such as autologous stem cell transplant without evidence for persistent or progressive disease does not preclude enrollment Patients must meet one of the following two requirements:\r\n* Have achieved minimal response (MR) or stable disease (SD) in current treatment regimen after receiving a minimum of two cycles\r\n* Have a partial response but show a decrease less than % or an increase less than % in measurable disease over a two month period\r\n** NOTE: Patients may be refractory to primary therapy or relapsed and have measurable or assessable disease; (refractory disease is defined as anything less than partial response [PR] or progression within days of completing therapy) Patient must have had a complete response (CR)/partial response (PR)/stable disease (SD), - weeks after completing last fraction of radiation therapy Patients must have achieved a complete response to induction chemotherapy (+/- thoracic radiation therapy) assessed according to local habits (at least on a chest x-ray) at the time of study entry Patients with acute undifferentiated, biphenotypic, or bilineal leukemia, which is in st or greater complete remission (CR) or partial remission (PR):\r\n* Cr will be defined as an M marrow (< % blasts), no evidence of extramedullary disease, and an absolute neutrophil count >= . x ^/L; cases where the ANC is < . x ^/L and rising will also be considered; the PI will need to approve such cases for enrollment; CR without platelet recovery (CRp) will be considered complete remissions); PR will be defined as an M marrow (-% blasts), no evidence of extramedullary disease, and an absolute neutrophil count >= . x ^/L); cases where the ANC is < . x ^/L and rising will also be considered; the PI will need to approve such cases for enrollment\r\n* Chronic myelogenous leukemia (CML):\r\n** Chronic phase with resistance to tyrosine kinase inhibitors\r\n** Accelerated phase (development of cytogenetic abnormality in addition to t(:), blood blast percentage >= , blood basophil percentage >= , platelet count < , X ^/L)\r\n** Blast crisis\r\n** nd or greater chronic phase\r\n* Acute Lymphoblastic Lymphoma in nd or greater complete remission:\r\n** Complete remission includes confirmed complete response (CR) defined as the disappearance of all evidence of disease from all sites for at least weeks; bone marrow and cerebrospinal fluid (CSF) must be normal and any macroscopic nodules in any organs detectable on imaging techniques shall no longer be present; imaging should include positron emission tomography (PET) scanning; CR will also include unconfirmed complete responses defined as a residual lymph node mass > . cm in greatest transverse diameter that has regressed by > % in sum of the products of the greatest perpendicular diameters (SPD), or any residual lesions in organs that have decreased by > %, with a negative PET scan, negative bone marrow and CSF\r\n* Peripheral T cell lymphoma (PTCL):\r\n** In first response (must have at least a partial response)\r\n*** PTCL, unspecified\r\n*** Hepatosplenic gamma-delta T cell lymphoma\r\n** Recurrent PTCL (must be treatment sensitive with at least a partial response); if patient has had a previous autologous transplant, the melphalan and fludarabine conditioning regimen must be utilized\r\n** Chronic myelomonocytic leukemia\r\n** Atypical (breakpoint cluster region- abelson murine leukemia viral oncogene homolog [BCR-ABL] negative) chronic myelogenous leukemia\r\n** Hodgkin lymphoma that has recurred or progressed after an autologous BMT\r\n*** Newly diagnosed or recurrent disease initially refractory to intensive chemotherapy; a partial response or better must be achieved prior to transplantation; eligibility of newly diagnosed cases must be discussed with the study principal investigator (PI)\r\n*** Disease that has recurred or progressed after an autologous BMT; salvage chemotherapy must produce a partial response or better; the melphalan and fludarabine conditioning-regimen must be used for these patients\r\n** Non-Hodgkin lymphoma other than lymphoblastic or peripheral T cell lymphoma\r\n*** Newly diagnosed or recurrent disease initially refractory to intensive chemotherapy; a partial response or better must be achieved prior to transplantation; eligibility of newly diagnosed cases must be discussed with the study PI\r\n*** Disease that has recurred or progressed after an autologous BMT; salvage chemotherapy must produce at least a partial response; the melphalan and fludarabine conditioning-regimen must be used for these patients (Part B only) Histologically confirmed DLBCL/MCL/FL/PTCL/MF/CLL on the basis of excisional lymph node or extranodal tissue biopsy; diagnosis of relapsed/refractory disease defined as ) recurrence of disease after a Complete Response (CR), or ) Partial Response (PR), Stable Disease (SD) at completion of treatment regimen preceding entry into study, subjects must not be candidates for standard therapy, subjects who have not received Stem Cell Translplant (SCT) must be ineligible to receive SCT. Patients with benign hematologic disorders such as severe aplastic anemia do not have disease response requirements; patients with a malignant hematologic disorder must be in complete response (CR) (MRD is allowed) with the exception of the following:\r\n* Patients with MDS/MPN only require < % myeloblasts on bone marrow evaluation\r\n* Patients with AML or ALL may be in complete remission with incomplete marrow recovery (CRi), patients with MM may be in very good partial response (VGPR) Pathologic complete response following preoperative chemotherapy Patients must have achieved a complete or near complete radiologic tumor response on breast imaging with mammogram, ultrasound, and MRI Complete response by PET achieved with pre-radiation therapy treatment (surgery or chemotherapy) Patients must have high-risk neuroblastoma with at least ONE of the following:\r\n* Recurrent/progressive disease at any time; biopsy is not required, even if there is a partial response to intervening therapy\r\n* Refractory disease (i.e. less than a partial response to frontline therapy, including a minimum of cycles of chemotherapy); no biopsy is required for eligibility for this study Complete response by PET achieved with pre-radiation therapy treatment (surgery or chemotherapy) Failure to achieve at least partial response (PR) with, or documented disease progression after, the most recent treatment regimen Patients years of age and older who are being evaluated for and/or treated for cancer at the NIH Clinical Center or at participating sites:\r\n* Who have a newly diagnosed malignancy for which they have not yet received treatment, or\r\n* Who have a previously treated malignancy that is now recurrent or currently progressing on treatment indicated by:\r\n** Radiographic evidence of tumor growth and/or new metastases, or\r\n** Documented evidence by the treating physician of signs/symptoms of clinical disease progression, or\r\n* Who are currently undergoing treatment (adjuvant, neoadjuvant, etc.), are within the first two () cycles of treatment, and for whom disease response has not yet been assessed\r\n** In this circumstance, specimen collection should occur as distant in time from the most recent drug administration as possible such as after completion of a treatment cycle and immediately prior to initiation of the next cycle\r\n* For matched pair collections only (tissue + blood), patients with ongoing partial response (PR) or stable disease (SD) are eligible\r\n** Confirmation of viable malignancy and/or < % tumor necrosis must be confirmed to the coordinating site, as indicated in the final pathology report, for patients enrolled with PR or SD Blood only collections from patients with partial or stable disease response\r\n* Blood will not be collected from patients whose disease demonstrates ongoing partial response or with ongoing (i.e., prolonged) stable disease given the poor rate of model generation from such samples\r\n* Blood will not be collected from patients between doses within a single treatment cycle no partial cytogenetic response by weeks (ie, to % Ph-positive) (whether lost or never achieved) no major cytogenetic response by weeks (ie, ?% Ph-positive) (whether lost or never achieved) Documentation of target and non-target lesion(s) status per RECIST. post induction chemotherapy for patients with evaluable disease\r\n* Note: Evaluable disease is not required for study entry (patients with complete response [CR] or response sufficient to preclude measurable lesions are not excluded; such patients will be evaluated for PFS and OS, but not for response) Has relapsed (disease progression after most recent therapy) or refractory (failure to achieve Complete Response [CR] or Partial Response [PR] to most recent therapy) classical Hodgkin Lymphoma.